PPT-CELL INJURY & Inflammation - II

PRACTICAL 2 I Acute Inflammation Foundation Block Pathology Dept KSU Pathogenesis of Exudation The diagram shown here illustrates the process of exudation aided by endothelial cell contraction and vasodilation which typically is most pronounced in venules. . Manar. . Hajeer. , MD, . FRCPath. Plasma derived mediators of . acute inflammation. Complement . system. Coagulation . and . Kinin. systems. Complement system. Complement . components are , C1 – C9, circulate in the blood in an inactive form. Its purpose is to . localize. ,. . eliminate. the injurious . agent, . remove . damaged tissue . and . replace. it with healthy new tissue (. repair. ). . It consist principally of vascular changes associated with leukocyte infiltration and systemic reaction.. Four Stages in Skin Healing. Inflammation. Blood flow increases. Phagocytes attracted. Scab formation. Cell division and migration. Scar formation. Bleeding occurs at the site of injury immediately after the injury, and mast cells in the region trigger an inflammatory response.. rubor. (redness), . calor. (heat), tumor (swelling), dolor (pain), and loss of function. Seen here is skin with . erythema. , compared to the more normal skin at the far right.. The arm at the bottom is swollen (edematous) and reddened (. Acute. – quick onset, short duration. Adhesion. – a sticking together or binding of tissue fibers. Antiseptic. – a substance which prevents the growth of bacteria. Avascular. – without blood or . J. Matthew Velkey. matt.velkey@duke.edu. 454A Davison, Duke South (green zone). Cellular Adaptation to Injury or Stress. Injury or Stress. Increased demand. Decreased stimulation or lack of nutrients. Professor. DEPT OF PATHOLOGY. SKHMC. Inflammation is a complex reaction to injurious agents such as microbes & damaged usually necrotic cells , that consists of vascular responses ,migration, & activation of leucocytes & systemic reactions. . د هبة احمد غيدان. LEC . 2. Cells of acute inflammation:. 1. . Neutrophils. : . Most prominent cells in acute inflammation during first 6hrs -24hrs.. 2. . monocytes. ----macrophages: . Inflammation is a set of symptoms that include pain, swelling, heat, and redness of an affected organ or tissue. It is the natural way the body’s immune system responds to injury, infection or attack. ASSISTANT PROFESSOR. WEST MEDICAL WARD. MAYO HOSPITAL/K.E.M.U. 1. DEFINITION OF INFLAMMATION. . Inflammation is a defensive process that a living body initiates against local tissue damage. It takes the form of a complex reaction of blood vessels, certain plasma components and blood cells, and cellular and structural components of connective tissue. . 1 IN THE HEALING PROCESS by Keith Wassung 2 The role of inflammation in the process of healing has been misunderstood for many years. Recent neurological and immunological research has shed light Associate professor, Pathology. Sri Venkateswara Institute of Medical Sciences, Tirupathi. CHRONIC INFLAMMATION. Characterized by . inflammation of prolonged duration . in which active inflammation, tissue destruction & attempts at repair are proceeding simultaneously . Lecture 2. Dr. Mohanad Al-Hindawi. 2022. Cellular changes of acute inflammation.. A critical function of inflammation is to deliver leukocytes to sites of injury (recruitment), especially those cells capable of phagocytosing microbes and necrotic debris (e.g., neutrophils and macrophages).. . cell injury, as well as the necrotic cells and tissues resulting from. . the original insult, and to initiate the process of repair.. INFLAMMATION. Inflammation can be acute or chronic. Acute. .