KiWon Kim et al Analysis of CIN 3 detected by punch biopsy Among 104 73 702 got cervical smear before punch biopsies There were 2 27 patients with in ammation 7 96 with atypical squ ID: 939764
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WWW.KJOG.ORG Ki-Won Kim, et al. Analysis of CIN 3 detected by punch biopsy Among 104, 73 (70.2%) got cervical smear before punch biopsies. There were 2 (2.7%) patients with in ammation, 7 (9.6%) with atypical squamous cells of unknown signi cance, 5 (6.9%) with atypical squamous cells exclude high-grade lesions, 8 (11.0%) with low-grade squamous intraepithelial lesion (LSIL), 46 (63.0%) with high-grade squamous intraepithelial lesion (HSIL), 2 with squamous cell carcinoma and 3 (4.1%) with unsatisfactory. At LSIL group, 1 (1.3%) patient contracted cervical cancer IA1 and at HSIL group, 3 (6.5%) did cervical cancer IA1. Human papillomavirus (HPV) positive rate for the patients were 80% (48/60) (Table 4).Among 59 patients who underwent cone, 3 (5.1%) patients had cal cancers. Among 45 patients who did not, 3 (6.7%) and the cancers (Table 5). The ef cacy of cervical cone biopsy in t
he diagnosis of CIN was well known [10]. The conization rate of the catchment area at our institution when CIN 3 were found by punch biopsies was 13-71%. It depends on the year the biopsies were done and the age of the patients. The nearer the dates operated were and the younger the patients were, the higher conizations were done [11]. At our 10 year experiences, the rate of conization was 56.7%. Most previous reports of the accuracy of colposcopically directed biopsy versus cone histology diagnosis have been descriptive eval- Table 4. The nal pathology according to the cervical smear and HPV results Cervical smearn (%)No lesionCIN 1CIN 2CIN 3CXCa IA1CXCa IB2In ammation2 (2.7) 2ASCUS7 (9.6)1 6ASCH5 (6.9)1 4LSIL 8 (11.0)11 51HSIL46 (63.0)312373SCC2 (2.7) 2Unsatisfactory3 (4.1) 3Not done31112621Total1044358561 Positive48 (80.0)24231 Negative12 (20)1 92 Not done4
4212372 Total2338871CIN, cervical intraepithelial neoplasia; CXCa, cervical cancer; ASCUS, atypical squamous cells of unknown signi cance; ASCH, exclude highgrade lesions; LSIL, lowgrade squamous intraepithelial lesion; HSIL, highgrade squamous intraepithelial lesion; SCC, squamous cell carci-noma; HPV, human papillomavirus. Table 5. The correlation of punch biopsy with the result of cone and/or hysterectomy PathologyConeHysterectomyLess than CIN 1CIN 2CIN 3IA11B1Less than CIN 1CIN 2CIN 3IA1Number32503133354%5.13.484.75.11.76.76.777.88.9CIN, cervical intraepithelial neoplasia; IA1, cervical cancer IA1; IB1, cervical cancer IB1. WWW.KJOG.ORG Ki-Won Kim, et al. Analysis of CIN 3 detected by punch biopsy 10. Kim BG, Kim JH, Song ES, Shim SD, Choi YM, Kang SB, et al. The ef cacy of cervical cone biopsy in the diagnosis of the cer-vical intraepithelial neoplasia. Korean J Gynec
ol Oncol Colposc 11. Song ES. The change of trend on surgical treatment of pa-tients with cervical intraepithelial neoplasia 3 in Incheon and Bucheon area. Korean J Obstet Gynecol 2005;48:2330-5.12. Denny LA, Soeters R, Dehaeck K, Bloch B. Does colposcopi-cally directed punch biopsy reduce the incidence of negative 13. Spitzer M, Chernys AE, Seltzer VL. The use of large-loop exci-sion of the transformation zone in an inner-city population. 14. Massad LS, Halperin CJ, Bitterman P. Correlation between colposcopically directed biopsy and cervical loop excision. Gy-15. Vergote IB, Makar AP, Kjørstad KE. Laser excision of the trans-formation zone as treatment of cervical intraepithelial neopla-sia with satisfactory colposcopy. Gynecol Oncol 1992;44:235-9.16. Zuchna C, Hager M, Tringler B, Georgoulopoulos A, Ciresa-Koenig A, Volgger B, et al. Diagnostic accuracy of guided cer-vical biopsi
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