source are credited IntroductionMELAS syndrome mitochondrial cytopathy encephalomyopathy lactic acidosis and strokelike episodes is a rare maternally inherited multisystemic disease caused by mi ID: 944119
Download Pdf The PPT/PDF document "Corresponding authorMingzheng Aaron Goh ..." is the property of its rightful owner. Permission is granted to download and print the materials on this web site for personal, non-commercial use only, and to display it on your personal computer provided you do not modify the materials and that you retain all copyright notices contained in the materials. By downloading content from our website, you accept the terms of this agreement.
*Corresponding author:Mingzheng Aaron Goh, Department of Surgery, Basildon and Thurrock University Hospitals, NHS Foundation Trust, Nethermayne, Basildon, UK, Tel: +447966637683; E-mail: , 2017, 2017; Goh MA, Dindyal SGoh MA This is an open-access article distributed under use, distribution, and reproduction in any medium, provided the original author and source are credited. IntroductionMELAS syndrome (mitochondrial cytopathy, encephalomyopathy, lactic acidosis and stroke-like episodes) is a rare maternally inherited multisystemic disease caused by mitochondrial dysfunction [1,2]. It is characterised by stroke like episodes, resulting in hemiparesis, hemianopia or cortical blindness. Other features include migraine-like headaches, progressive dementia, and muscle weakness, diabetes mellitus, hearing loss, cardiac disease and short stature.MELAS typically presents in childhood a er a normal early development recently it has been recognised that adult onset of symptoms can occur [1-4]. A relapsing-remitting course is most common, with stroke-like episodes leading to progressive neurological dysfunction and dementia. ere is persistent lactic acidosis. Histologically, there are ragged red bres on muscle biopsy and accumulation of abnormal mitochondria in smooth muscle. 1. Vivo (encephalopathy episodes: A . Ann . 2. . ( Weekly exercises. Case39-1998. A 13yearoldgirlwitharelapsing disorder. . 3. KawabataTachibanaencephalomyopathyTokyo 4. Tian. ( recordsoftheMassachusettsGeneral Hospital. Case36-2005. A 61 woman 353. 5. Scaglia F, Northrop JL (2006) Themitochondrial myopathyencephalopathy, lacticacidosis withstrokeepisodes (MELASsyndrome: A review oftreatment. . 6. Karppa MHervaRMoslemi AROldforsAKakkoSetal. (2005) Spectrumofmyopathic in50patientswiththe3243A& 7. Takeuchiencephalomyopathy 8. ( ileus. 9. DPA 10. Wolf Goh and Dindyal, Prim Health Care 2017, 7:1DOI: Commentary Journal of PrimaryHealthcare: Open AccessISSN: 2167-1079 Primary Health Care: Open Access 11. SuXKangPBRussell JASimmonsZ (2016) Ethicalissuesintheevaluation neuromuscular 54. 12. . (donation - Mingzheng Aaron Goh* and Shiva DindyalDepartment of Surgery, Basildon and Thurrock University Hospitals NHS Foundation Trust, UK