In preliminary tests in pigs absorber bound 64 of chemo drug on average Scientific Achievement Researchers have designed a biomedical device for absorbing excess chemotherapy drugs during cancer treatment characterizing the active surface layer using xray microtomography ID: 777760
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X-ray microtomography nondestructively validated coating uniformity throughout.In preliminary tests in pigs, absorber bound 64% of chemo drug, on average.
Scientific AchievementResearchers have designed a biomedical device for absorbing excess chemotherapy drugs during cancer treatment, characterizing the active surface layer using x-ray microtomography. Significance and ImpactThe work opens up a new route to fighting cancer that minimizes drug toxicity and enables personalized, targeted, high-dose chemotherapy.Research Details Cylindrical absorber: 5 mm in diameter, 30 mm long.Complex internal structure with absorbent coating.
(a) X-ray microtomographic recon-struction of absorber scaffolding (gray) and block copolymer coating layer (orange). (b) Magnified view.
Publication about this research: H.J. Oh, M.S. Aboian, M.Y.J. Yi, J.A. Maslyn, W.S. Loo, X. Jiang, D.Y. Parkinson, M.W. Wilson, T. Moore, C.R. Yee, G.R. Robbins, F.M. Barth, J.M. DeSimone, S.W. Hetts, and N.P. Balsara, ACS Cent. Sci., doi:10.1021/acscentsci.8b00700 (2019). Work was performed at Lawrence Berkeley National Laboratory, ALS Beamline 8.3.2. Operation of the ALS is supported by the U.S. Department of Energy, Office of Science, Basic Energy Sciences program.
Absorber Captures Excess Chemotherapy Drugs