PPT-Switch to PI/r + 3TC

vs PIr monotherapy Study PIVOT Study MOBIDIP LPVr monotherapy N 82 Design Randomisation 1 1 Openlabel Objective Primary endpoint failure rate at W96 by ITT defined as 1 a confirmed HIV . The IATT Optimal Pediatric ARV List. . Presented at IAS - July 2012. Dr. Nandita Sugandhi. . Clinical Advisor at the Clinton Health Access Initiative (CHAI). Released April 23, . 2012:. Who is the IATT?. (with perspectives from well-resourced and resource-limited settings). Gareth Tudor-Williams. Imperial College London. UK. Where would you prefer to be right now?. Langkawi resort?. Attending a workshop?. FLAMINGO. GS-236-0103. ACTG A5257. WAVES. ARIA . Design. Objective. Non inferiority of DTG/ABC/3TC at W48: % HIV RNA < 50 c/mL by intention. to treat, snapshot analysis (lower margin of the 2-sided 95% CI for the difference = - 12%). STRIIVING . Study. Design. Endpoints. Primary: proportion of patients maintaining HIV RNA < 50 c/mL at W48 . (ITT-E, snapshot) ; non-inferiority if lower margin of the two-sided 95% CI . for the difference = - 10%, 90% power . Susan M. Graham . Assistant Professor, Medicine and Global Health. Adjunct Assistant Professor, Epidemiology. Presentation prepared by: . Susan M. Graham. Last Updated: . October 29, 2014. Susan M. Graham, MD MPH PhD. 2. Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Mexico City, Mexico; . 3. Hospital La Paz, Madrid, Spain; . 4. Istituto Nazionale per le Malattie Infettive Lazzaro Spallanzani, . ATV/r 300/100 mg QD 3TC 300 mg QD. N = 133. N = 133. Continuación ATV/r 300/100 mg QD 2 NRTI . Diseño. Randomización. 1:1. Etiqueta abierta. Objetivo. Endpoint. primario: proporción de pacientes sin fallo al tratamiento a S48 . Joseph J. Eron, Jr, MD. Professor of Medicine. University of North Carolina. Chapel Hill, North Carolina. Panelists. Constance Benson. Hyman Scott. Annie . Luetkemeyer. Robert . Schooley. Financial Relationships With Commercial Entities. Dovato. ). Last Updated: November 28, 2022. Prepared by:. Brian R. Wood, MD. David H. Spach, MD. Dolutegravir-Lamivudine. Photograph courtesy of . ViiV. INSTI. NRTI. 50 mg. 300 mg. Dolutegravir-Lamivudine. –. NAIVE ADULTS WITH HIV-1 INFECTION: 96-WEEK RESULTS FROM THE GEMINI STUDIES. 1. Fundación Huesped, Buenos Aires, Argentina; . 2. Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Mexico City, Mexico; . ARV . strategies. DOR > DRV/r 1st line. (DRIVE-FORWARD W96). DTG. monotherapy. Switch PI/r-DTG (NEAT22). Switch RPV+DTG . (SWORD). Test and . Treat. D/C/F/TAF . (DIAMOND). −10% noninferiority margin for individual studies.. STEAL. Switch NRTIs to Tenofovir DF-Emtricitabine or Abacavir-Lamivudine. STEAL: Study Design. Source: . Martin A, et al. . Clin. Infect . Dis. 2009;49:1591. -1601. .. Study Design: STEAL. Background. 1. ViiV Healthcare, Brentford, UK; . 2. Centre Hospitalier de Tourcoing, Tourcoing, France; . 3. Holdsworth House Medical Brisbane, Queensland, Australia; . 4. CHU Saint-Pierre, Brussels, Belgium; . 5. DRV/r 800/100 + 3TC 300 QD. N = 126. N = 123. DRV/r + ABC/3TC or TDF/FTC QD. Design. Randomisation*. 1: 1. Open-label. Objective. Non inferiority of DRV/r + 3TC at W48: % HIV RNA < 50 c/mL by intention to treat-exposed, snapshot analysis (lower margin of the 2-sided 95% CI for the difference = - 12%, 80% power).