Dawn Langdon PhD MS care providers needs Most interested in receiving consultation on cognition 310 Most interested in CME relating to cognition 401 Highest preference for live conference ID: 756851
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Slide1
Brief Cognitive Assessment based on Consensus Standards in the US and Abroad
Dawn Langdon PhDSlide2
MS care providers needs
Most interested in receiving consultation on cognition (31.0%)Most interested in CME relating to cognition (40.1%)Highest preference for live conference
Turner et al., JRRD 2006;43:25-34Slide3
MS patients’ information needs
All those questions recommended information about cognition in MS for all patientsAnd on average to be given earlier than they had received it
Heesen
et al.,
Acta
Neurol
Scand 2006;114:268-272Slide4
Assessment of Cognition
Comprehensive Batteries
Intermediate length Batteries
Brief Batteries
Screening tests
MSNQ
BRB
SEFCI
MACFIMS
Ad hoc
Routine in the office
Routine NP exam.
Differential diagnosis
Disability questions
Rehabilitation programs
4Slide5
Cognitive assessment for MSRequires specialist training
Time-consumingNot routinely available outside specialist centresNot comparable across countriesSlide6
BICAMSBrief International Cognitive Assessment for MS
Identify a brief assessment tool for cognition in MS
can be used by health care professionals who are not cognitive specialists
has international validation
Specify an international validation protocol that can be implemented in any country
Agree guidelines on test-retest timing and clinically significant change
6
BICAMS committee meetings and website are sponsored by Bayer HealthcareSlide7
BICAMS committee meetings and website are sponsored by Bayer HealthcareSlide8
BICAMSBrief International Cognitive Assessment for MS
Identify a brief assessment tool for cognition in MS
80 key scientific articles identified
Each article rated by two committee members
Psychometric standards
Reliability
Validity
Sensitivity
Pragmatic standards
International applicability
Ease of administration
Feasibility in the specified context
Acceptability to patients
8BICAMS committee meetings and website are sponsored by Bayer HealthcareSlide9
BICAMSBrief International Cognitive Assessment for MS
No materials required beyond papers, pencil and stopwatch
BICAMS committee meetings and website are sponsored by Bayer HealthcareSlide10
Benedict et al. Clin Neuropsychol 2002; 16: 381-97Slide11
11
Neuropsychological Evaluations
California Verbal Learning Test-II (CVLT II)
Truck
Spinach
Giraffe
Bookcase
Onion
Motorcycle
Cabinet
Zebra
Coach
Lamp
Celery
Cow
DeskBoatSquirrelCabbage
Benedict et al. Clin Neuropsychol 2002; 16: 381-97Slide12
Brief
Visuospatial Memory Test (Revised)
RHB Benedict (Clin Neuropsych 1994; Psychol Assess 1996;
Psychol Assess Resources 1997).
Benedict et al. Clin
Neuropsychol
2002; 16: 381-97
12Slide13
BICAMS
Brief International Cognitive Assessment for MS
Battery:
SDMT
CVLT-II, first recall trials
BVMTR, first recall trials
13
BICAMS committee meetings and website are sponsored by Bayer HealthcareSlide14
MS patients compared to healthy controls on BICAMS
Parmenter et al., JINS 2010;16:6-16
MS (n=395)
Mean
SD
Controls
(n=100)
Mean
SD
P value
d’
Age
46.28
8.99
44.79
9.43ns0.16Education14.28
2.3414.471.72ns0.09BDI-FS3.39
3.400.901.40<.0010.96
SDMT49.5313.2061.40
9.31<.0011.04
CVLT-II TL48.8010.5655.79
9.35<.0010.70
BVMTR TL20.92
7.1726.685.56
<.0010.90Slide15
Raw score to scaled score conversionParmenter
et al., JINS 2010;16:6-16
Scaled score
SDMT
CVLT-II (learning trials)
BVMTR (learning trials)
2
<13
3
<43
<32
13
4
43-35
32-35
14-15546
36-4316647-5044-46
17-19751-5447-4820-22
855-5649-5123-24
957-5952-53
25-2610
60-6354-5727-28
1164-6658-60
29-301267-69
61-633113
70-72
64-66
32
14
73-74
67-70
33
15
75-78
71-73
34-35
16
79
74
17
80-87
18
>87
>74
36Slide16
BICAMS committee meetings and website are sponsored by Bayer HealthcareSlide17
BICAMSBrief International Cognitive Assessment for MS
Identify a brief assessment tool for cognition in MS
can be used by health care professionals who are not cognitive specialists
has international validation
Specify an international validation protocol that can be implemented in any country
17
BICAMS committee meetings and website are sponsored by Bayer HealthcareSlide18
BICAMSBrief International Cognitive Assessment for MS
international validation protocol
Step 1, Standardization and Translation of Test Stimuli.
Step 2, Standardization and Translation of Test Instructions
Step 3, Normalization
Step 4, Test-Retest Reliability
Step 5, Criterion-Related Validity
Benedict et al., BMC Neurology (submitted)
BICAMS committee meetings and website are sponsored by Bayer HealthcareSlide19
BICAMS
Brief International Cognitive Assessment for MS:
National Validations
Country
NC
n
MS n
Data collection started
Data collection completed
Analysis started
Analysis completed
Publi-cation
BICAMS support
Argentina
TBD
TBDPending
PendingPendingPending
PendingRHB Benedict
Czech Repub92130
Mar 2010Ongoing
PendingPending
Pending
RHB BenedictIran
15890
Mar 2010Sep 2011
Oct 2011
Nov
2011
Submitted
RHB Benedict
Argentina
TBD
TBD
Pending
Pending
Pending
Pending
Pending
RHB Benedict
UK
60
60
Pending
Pending
Pending
Pending
Pending
DW Langdon
Egypt
TBD
TBD
Pending
Pending
Pending
Pending
Pending
D W
Langdon
Estonia
TBD
TBD
Pending
Pending
Pending
Pending
Pending
DW Langdon
Italy
TBD
TBD
Pending
Pending
Pending
Pending
PendingMPAmato
19Slide20
BICAMSBrief International Cognitive Assessment for MS
Identify a brief assessment tool for cognition in MS
can be used by health care professionals who are not cognitive specialists
has international validation
Specify an international validation protocol that can be implemented in any country
Agree guidelines on test-retest timing and clinically significant change
20
BICAMS committee meetings and website are sponsored by Bayer HealthcareSlide21
Assessment of Cognition
Comprehensive Batteries
Intermediate length Batteries
Brief Batteries
Screening tests
Screening tests
Brief Batteries
Routine in the office
Routine NP
exam
Differential diagnosis
Disability questions
Rehabilitation programs
21
BICAMS
Routine in the clinic
0
mins
15
mins
45
mins
90
mins
120
mins