Learning Objective To be able to explain the sliding filament theory using key terminology Structure of a Muscle Skeletal muscle is made up of bundles of muscle fibres Fibres are bound together by connective tissue through which run blood vessels and nerves ID: 533145
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Slide1
Muscle Contraction and the Sliding Filament Theory
Learning Objective:
To
be able to explain the sliding filament theory
using key
terminology.Slide2
Structure of a Muscle
Skeletal muscle is made up of bundles of muscle
fibres
.Fibres are bound together by connective tissue through which run blood vessels and nerves.Slide3
Structure of a Muscle
Each muscle
fibre
contains:Numerous myofibrils,Many mitochondria,
An extensive network of interconnecting tubes called the sarcoplasmic reticulum,
Many nuclei.Slide4
The Microstructure of a Muscle
Muscle fibres contain thread like
myofibrils
.Myofibrils consist of repeated units called sarcomeres.
Each sarcomere is divided from the next by Z lines and contains two protein filaments: the thin
actin
filaments and the thick myosin filaments.Slide5Slide6
The Microstructure of a Muscle
Muscle
contraction occurs as the sarcomere shortens due to myosin filaments pulling the actin
filaments inwards.This results in the actin and myosin filaments being drawn closer together and the whole muscle shortening.Slide7
Sliding Filament Theory
In its most basic form:
Muscle contraction occurs when the myosin and actin filaments slide across each other.
What actually occurs is myosin pulls the actin in.This shortens the muscle and is a muscle contraction.Slide8
Sarcomere and Muscle Contraction
During muscle contraction in the sarcomere:
The Z lines come closer together,
The width of the I band (area of actin not overlapping myosin) decreases,
The width of the H zone (area of myosin not overlapping with actin) decreases,
No change in the width of the A bands (myosin).Slide9
How does it all happen?
Video clip explaining the sliding filament theory.
A nerve impulse arrives at the neuromuscular junction (place where motor neurone links to muscle fibre).
At rest tropomyosin (a protein that winds around actin) strands prevent myosin from attaching to and pulling actin
.
At rest the sarcoplasmic
reticulum (a network of channels that spread over the surface of the myofibril) stores large amounts of calcium ions.Slide10
How does it happen?
To initiate a muscle contraction
the electrical
nerve impulse travels into a myofibril via the transverse tubules and triggers the release of calcium ions from the sarcoplasmic reticulum.The calcium ions bind to troponin (a globular protein on actin)
causing it to change shape.
As it does this it
moves tropomyosin and frees up the actin binding site for myosin
.
Myosin binds to actin (forming a cross bridge),
activating myosin ATP-
ase
(an enzyme).Slide11
This enzyme causes ATP to breakdown and energy is released.
The energy causes the myosin head to pull the actin filament along (known as the power stroke).
Myosin detaches and reattaches further along pulling actin in with a ratchet-like mechanism.
This
process of muscular contraction can last for as long as there is adequate ATP and
Ca
+ stores. Once the impulse stops the Ca+ is pumped back to the sarcoplasmic reticulum
and the
actin
returns to its resting position causing the muscle to lengthen and relax.
Another clip to explain the sliding filament theorySlide12
Or picture the scene…
Starring:
Sarah Actin
James MyosinBen & Matt ( the Calcium brothers)Emily & Louise (the Tropomyosin sisters)Slide13
On a night out…
James
M
yosin likes Sarah Actin.Unfortunately Sarah Actin is with her two mates, the Tropomyosin sisters.James’ friends Ben & Matt Calcium admirably take one for the team and go to chat up the Tropomyosin sisters.With some smooth words they move the
T
ropomyosin out of the way, thus freeing Sarah Actin for James
Myosin to head in for the pull!!After a bit of ‘action’ it’s getting late so the Calcium brothers head home meaning that the Tropomyosin sisters return forcing James Myosin and Sarah Actin to go their separate ways.Slide14
Homework
Explain the sliding filament theory in your own words.
First, try it from
memory (omitting any key terms if you can’t remember them straight away)Then, re-watch the YouTube clip and fill in any blanks.You must include the following terminology: Muscle fibre, myofibril,
actin
, myosin,
sarcomere, I Band, A Band, H Zone, Z Lines, Sarcoplasmic reticulum,
troponin
,
tropomyosin
, transverse tubules, calcium ions, ATP, myosin ATP-
ase
.