R25 DA031608 HIV & Drug Abuse Prevention Research Ethics - PowerPoint Presentation

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R25 DA031608

HIV

& Drug Abuse Prevention Research Ethics

Training Institute (RETI)

Ethics Training at the Forefront of HIV and Drug Abuse Research

Celia B. Fisher, Ph.D.

Director, HIV/Drug Abuse Prevention Research Ethics InstituteMarie Ward Doty University Chair in Ethics Professor of PsychologyDirector Center for Ethics Educationfisher@fordham.edu

Why We Are Here

The global HIV/AIDS and drug abuse pandemics urgently require empirically informed interventions

Population vulnerabilities create

e

thical challenges and

jeopardize scientific validity and participation protectionsMoral reflections of Investigators and IRBs are

insufficient

Needed: An empirical basis for research ethics policies and practices reflecting participant values and lived experiences.

Institute

Basics

Now approaching its 8th

year, the NIDA

funded HIV/drug abuse research ethics training institute (RETI) has

admitted 43 early-career investigators in the social, behavioral, medical and public health fields.Trainees:Attend 2 Summer Training Institutes in

NYC

Receive $20,000 to

conduct

a Mentored Research Project (MRP) on ethical issues in HIV and drug use

research

Engage communities in research design, implementation, and disseminationHave access to a web-based platform for HIV/drug abuse prevention ethics resources and collegial exchangeContinued mentoring for professional development

Summer Institute Curriculum

AIM 1: Increase

trainees’

knowledge of and capacity to address ethical issues in HIV/drug abuse prevention researchYear 1:

Seminars on current ethical challenges in HIV/drug abuse research, federal and international guidelines, methodologies for research on research ethics (ERRE) to strengthen research protections and advance scientific understanding

Year 2: Advanced seminars on ERRE methodology, publication, professional and community dissemination and grant writing incorporation with MRP as pilot study for new grant or grant supplement

Post-Institute: Continued guidance for publication, teaching, grant applications and professional development

Interdisciplinary

Faculty

and Advisory Committee

The program has outstanding, diverse multidisciplinary faculty with expertise in in the conduct and ethics evaluation of HIV and drug abuse prevention research conducted in the U.S. and in international settings.

Celia B. Fisher, PhD

Leslie Alexander, PhD*

Julia Arnsten, MD

Brandon Brown, PhD, MPH

Joann Casado, JD

Silvia Cunto-Amesty, MD

Brenda L. Curtis, PhD, MSPH*

Sherry Deren, PhD

Don C. Des Jarlais, PhDJames DuBois, PhD

David S. Festinger, PhD

Susan Fish, PharmD, MPH*

Timothy Flanigan, MD

Crystal M. Fuller, PhD, MPH

Lloyd Goldsamt, PhD*

Meredith Hanson, DSW

Richard Jenkins, PhD

Kaveh Khoshnood, MPH, PhD*

Mark Kinzly

Robert Klitzman, MD

Gerald P. Koocher, PhD

Robert Levine, MD

Sarah Lord, PhD*

Ruth Macklin, PhD

David Marcotte, SJ, PhD*

Michael Marshal, PhD

Patty Marshall, PhD

Tina Maschi, PhD

Lisa A. Marsch, PhD

E. Doyle McCarthy, PhD

Jon Frederick Merz, JD/PhD

Monica Rivera Mindt, PhD

Claudia Moreno, PhD

Brian Mustanski, PhD

Mary Ott, MD

Manoj Pardasani, MSW, PhD

Sean Philpott-Jones, PhD, MSB

Joseph G. Ponterotto, PhD

Robert Quiles

Alexis Roth, PhD, MPH

Michele Shedlin, PhD

Janie Simmons, EdD

A. Hal Strelnick, MD*

David H. Strauss, MD

Jeremy Sugarman, MD, MPH, MA

Joseph Trimble, PhD

Kristen Underhill, J.D., Ph.D.

Scyatta Wallace, PhD*

Margaret Weeks, PhD*

Mentored Research Project (MRP)

Pre-institute mentoring: Literature review and project abstract

A faculty mentor with expertise in trainees’ MRP

area providing regular in-person and online guidance over 2 years

$20,000 funding for data collection and dissemination

Training in publication and federal grant writing

AIM 2: Increase fellows’ capacity to design and implement ERRE exploring HIV/drug abuse current challenges encountered by trainees and their colleagues:

Community Advisory Boards (CABs)

2 CAB meetings are required at the design and interpretation stages of the MRP

Enhance multicultural competence in the selection, respectful recruitment and conduct of CABs

Sensitize trainees to

incorporate into research design the perspectives of persons with and at-risk for HIV/drug abuse,

community leaders, research workers and service providers

AIM 3: Increase capacity to engage communities in the construction, interpretation and dissemination of HIV/drug abuse research

Bronx Community Research Review Board

Examples of MRP Topics & Populations

Risks and benefits of peer

-delivered HIV

interventions with PWIDConfidentiality Concerns involving online recruitment, mHealth interventions, and geospatial mapping for HIV/drug use researchSocial and structural constraints for HIV survey and prevention research involving persons involved in sex workInformed consent vulnerabilities and enhancements involving YMSM, PLWH

IRB attitudes toward HIV/drug abuse research

Research capacity building for AIAN community membersRecruitment barriers and research mistrust among ethnic minority populations

Due and undue influence of monetary incentives for HIV/drug abuse researchSecondary trauma among HIV research staff

Brandon Brown: Ethics of HPV Vaccine Trials in

Peru

Lianne Urada:

Female Sex Workers Consent in the PhilippinesRoberto Abadie: Trust among PWID in Puerto

RicoCharmaine Thokoane: Sexual

health programs for youth in

South AfricaThespina Yamanis: HIV prevention in TanzaniaPurnima Madhivanan: Maternal HIV transmission in India Shira Goldenberg: FSW/Migrant Sex Workers

risks and benefits of research participation in

Guatemala

Thomas Guadamuz: Consent for YMSM in HIV prevention research in

Thailand

Sean Young: Social Media for HIV Prevention studies in

PeruAdrian Guta: Risks and benefits of research conducted in a supervised injectable opioid agonist therapy program in Canada

MRPs Around the World

MRP

Publications

Ethics & Behavior

Journal of Empirical Research on Research Ethics (JEHRE)PLOS OneAddictive Behaviors

Prevention Science: Official Journal of

the Society for Prevention ResearchAIDS Care

Substance Use & MisuseJournal of the International AIDS SocietyJournal of Psychoactive DrugsBMC: International Health and Human RightsThe Hastings Center ReportSexually Transmitted DiseasesJournal of Immigrant and Minority Health

Journal of the Association of Nurses

International Journal of Public Health

International Journal of Gynecology and Obstetrics: Official Journal of the International Federation of Gynecology and Obstetrics

Culture, Health & Sexuality

Since completing training, Institute fellows have published

over 300 articles related to HIV/drug abuse prevention and/or research ethics: 37 articles directly based on their MRP

MRP Professional Presentations

APHA Annual Meeting

APA Annual Meeting

PRIM&R Annual MeetingGEOMED Annual Meeting

International AIDS Conference

NIHSociety for Behavioral Medicine Annual Meeting

Society for Applied Anthropology Annual MeetingBritish Sociological Association Annual MeetingNational Bioethics ConferenceNational HIV Prevention ConferenceEDUCAVIDATo-date 42 MRP based presentations, post-institute 161 total

Institute Fellows at PRIM&R

Suzanne Carlberg-Racich John Sauceda Brenda Curtis

Award winners: Alexis Roth, Abby Rudolph, Kristen Underhill,

Suzanne

Carlberg-Rachich

AIM 4: CONTINUED PROFESSIONAL DEVELOPMENT

Kristen Underhill, JD, PhD

Associate Professor, Columbia University

“A Qualitative Study of Medical Mistrust, Perceived Discrimination, and Risk

Behavior: Disclosure

to Clinicians by U.S. Male Sex Workers and Other Men Who Have Sex with Men: Implications for Biomedical HIV Prevention,” July 2017

Alexis Roth, JD, PhD, MPHAssistant Professor, Drexel University“Persons who Inject Drugs’ Perspectives on the Risks and Benefits of Participation in aMobile Health (mHealth) Study of Polydrug Use,” July 2017Brenda L. Curtis, PhD, MSPHAssistant Professor, University of Pennsylvania

“Ethical Opportunities and Challenges Using Digital Media for HIV and Drug Abuse

Prevention Research,” July 2017

Brenda Curtis is also a member of the MAC

.

Brandon Brown, PhD, MPH

Assistant Professor, University of California, Riverside“Ethical Issues in Providing Payment for HIV and Drug Use Research,” July 2017RETI Alumni serve as institute faculty, mentors, and members of our advisory board and receive continued professional development guidance from RETI faculty

NIH Awards/Grants Post-Institute

Since

entering the Institute,

16 trainees have received NIH grants. Peter Davidson, Jennifer Hettema, Cynthia Pearson, Elizabeth Reed, Purnima Madhivanan

, Lianne Urada, Brenda Curtis, Thomas Guadamuz, Kristen Underhill,Alexis

Roth, Sean Young, Erin Bonar, Julia Lechuga, Abby Rudolph, Kimberly Nelson and Jonathon Rendina.

In 2017, the Institute website had

52,224

views and

31,142 visitors from over 160 countries!

Ethics & Society Blog

Downloadable Faculty Lectures

Research Ethics Scales and MeasuresHIV/Drug Abuse Research Ethics Bibliography (over 500 articles)Monthly Newsletter including NIH Funding Opportunities AIM 5: To provide online HIV/Drug abuse prevention research ethics resources for trainees and the global public

Media Platforms Featuring Institute

Fellows & Faculty

twitter.com/fordhamethics

facebook.com/fordhamethics

facebook.com/LGBTRELAY

instagram.com/fordhamethics

Fordham Ethics Channel

Today’s Institute

Fellows

Roberto Abadie, PhD

University of Nebraska-Lincoln,

Research Assistant Professor

Establishing Trust among People Who Inject Drugs (PWID) Enrolled in a Community Heath Study in Rural Puerto Rico

Kimberly Nelson, PhD, MPHBrown University/The Miriam Hospital,Assistant ProfessorIs guardian permission a barrier to sexual health research among adolescent males interested in sex with males (AMSM)?Jonathon Rendina, PhD, MPHCity University of New York – Hunter College and Graduate Center,Assistant Professor

To share or not to share? Examining perspectives on privacy, trust, and data sharing in web-based and mobile research among a large nationwide sample of men who have sex with men