PPT-Who gets IBD and Why?

Dr Miles Parkes Cambridge Dr Hannah Gordon London RSM and CCUK 2015 Introduction Who Epidemiology Why Heritability twin and family studies Genetics Environment Interface between Genes and Environment. crohnsandcolitisorguk Understanding IBD Ed 5 June 2014 brPage 2br Understanding IBD About this booklet If you have recently been diagnosed with Ulcerative Colitis UC or Crohns Disease the two most common forms of In64258ammatory Bowel Disease IBD y Athos Bousvaros MD, MPH. Advances in IBD Dec 2014. Disclosures (last 12 months). Consultant. Takeda/Millennium. Dyax. Cubist. Peabody Arnold (litigation). Research support. Prometheus. Questions. Should we use combination therapy in our pediatric IBD patients?. Eva Szigethy MD, PhD . Associate Professor of Psychiatry, Pediatrics and Medicine. Director, Visceral Inflammation and Pain (VIP) Center. Division of Gastroenterology. szigethye@upmc.edu. Szigethy: Disclosures. Judy H. Cho, M.D. . Ward-Coleman Professor of Medicine and Genetics, Icahn School of Medicine at Mount Sinai. Central importance of human genetics. Germline. DNA variants.  disease susceptibility. Dr. Hannah Gordon, Prof Timothy Orchard, . Dr. Alan Steel, . Dr. Marcus . Harbord. ECCO 2015 Barcelona. Declarations:. The authors have no competing interests. Funded by an unrestricted grant from the Jesse and Thomas Tam Family Foundation. Dr Hannah Gordon. Clinical Research Fellow. Chelsea and Westminster Hospital. Introduction. Review . History of twin studies. Twin studies in IBD. New molecular techniques in IBD. UK IBD Nixon Twin and Multiplex Registry. Inbreeding. Causes departure from Hardy-. Weinburg. Equilibrium. Reduces . heterozygosity. Changes genotype frequencies. Does . not change allele frequencies. http://scienceblogs.com/notrocketscience/2009/04/14/how-inbreeding-killed-off-a-line-of-kings/. Transplant . for Refractory . Clostridium difficile. in IBD Patients. Edward V. Loftus, Jr., MD. Professor of Medicine. Division of Gastroenterology and Hepatology. Mayo Clinic. Rochester, Minnesota. Inbreeding. Reduces . heterozygosity. Does not change allele frequencies. Inbreeding:. Breeding between closely related individuals.. H. f. = Heterozygosity observed in a population experiencing inbreeding . Jim . Gelder. , CEO, HCB. Trey Wall, VP, IBD Strategies, HCB. Garry Shelton, Director, National Sales Desk, HCB. Shift In Life Insurance Distribution. Independent . professional life agents . brokers . Keys to Successful Diagnosis, Treatment, and Ongoing Care. Lisa Malter, MD. Professor. Department of Medicine. Division of Gastroenterology. NYU Grossman School of Medicine. New York, New York. Dermot McGovern, MD, PhD, FRCP, FACG. colon. It is important to see a rheumatologist when this disease is suspected, as biologic treatments often help reduce complications and joint damage.DiagnosisIt is not always easy to determine if th Sara Horst MD MPH. Alan Moss MD . Extra-intestinal Manifestations. Prevalence and incidence depends on definition: 6-47%. Can appear before or after diagnosis. Rogler. G et al. Gastroenterology 2021. Making information work for patients, their clinical teams and the NHS. Stuart Bloom. Chair. , UK . IBD Registry. Consultant Gastroenterologist, UCL Hospitals. Chairs: Dr Stuart Bloom and Dr Fraser Cummings.