PPT-Autoimmunity And Immunodeficiency

Anna Postolova MD MPH AllergyImmunologyRheumatology Menlo Medical Clinic Stanford Health Care Disclosures Nothing to disclose Objectives Recognize aspects of history and presentation that are suggestive of a primary immunodeficiency or immune dysregulatory syndrome in rheumatology patients. Chris Lancaster, Emily Mathews, Jake Turner . Questions:. c.j.lancaster@warwick.ac.uk . Jake.Turner@warwick.ac.uk. E.K.Mathews@warwick.ac.uk. Definitions . Immunological . Tolerance:. Unresponsiveness . Quiz. Emily Matthews (. e.k.matthews@warwick.ac.uk. ). Chris Lancaster (. c.j.lancaster@warwick.ac.uk. ). Jake Turner (. jake.turner@warwick.ac.uk. ) . Question 1. Define autoimmunity ( 4 marks). 1) . Martin Liška. Immunodeficiency. = a disorder of immune system which manifests by impaired ability to carry out basic immunological functions, primarily defence against infection or immunological surveillance. . One infection. too many!. Dr. Ahmad AlKhabaz. , MBBS, FRCPC. Head of Pediatric Allergy & Clinical Immunology . U. nit. Chair of the allergy & immunology exam committee (KIMS). Tutor for the pediatric residency program (KIMS). Iga. deficiency - description. Description:. Serum IgA <5 mg/. dL. Normal serum IgG and IgM. Patients >1 year . Genetics:. Autosomal Dominant. Abnormalities on Chromosome 18. Associated with HLA-A1, HLA-A2, B8, and Dw3 . For MBBS (29.09.2017). By: . Dr. . . Puneet Kumar Gupta. Assistant Professor, M. icrobiology. ,. Introduction. . Immunodeficiency . diseases. Defence . mechanisms of . body are impaired→ repeated . . immunological tolerance. Immunological . tolerance is a state of unresponsiveness to a particular antigen to which a person has been exposed earlier. .. . . The important aspect of tolerance is the self-tolerance, which prevents the body to mount immune response against self-antigens. Dr. . Mayssaa. . Essam. Immunodeficiency . . . The . immunodeficiency may be the result of defective immunity, both innate and specific, because of . genetic. abnormality (. primary. ) or there is a loss of function because of the damage by . LECTURE : 07 LEARNING OBJECTIVES : The student should be able to: Describe the term "autoimmune", indicate if it is either Define the term "autoantibodies". Determine if the autoantibodies eit Patients with primary immunodeficiency diseasesmost often are recognized because of their increased(Table 2). In fact, non-infectious manifestations, suchodeficiency. Other immunodeficiency diseases m Autoimmunity. is the system of immune responses of an organism against its own cells and tissues. Any disease that results from such an aberrant immune response is termed an autoimmune disease.. These . Marian . Rewers, MD, PhD. Sponsors:. Patten-Davis Foundation. Autoimmunity Screening for Kids (ASK), 2017-2022 . Screened >30,000 Colorado general population children 1-17 y old. Prevalence of pre-symptomatic T1D - 1.0% (95%CI –0.9- 1.1%). Hypersensitivities. Hypersensitivity. Any immune response against a foreign antigen exaggerated beyond the norm. Four types. Type I (immediate). Type II (cytotoxic). Type III (immune complex–mediated). Immunodeficiency. = a disorder of immune system which manifests by impaired ability to carry out basic immunological functions, primarily defence against infection or immunological surveillance. Immunodeficies.