PPT-Autoimmunity And Immunodeficiency

Anna Postolova MD MPH AllergyImmunologyRheumatology Menlo Medical Clinic Stanford Health Care Disclosures Nothing to disclose Objectives Recognize aspects of history and presentation that are suggestive of a primary immunodeficiency or immune dysregulatory syndrome in rheumatology patients. Self-tolerance: concept, significance. Mechanisms of central and peripheral tolerance: deletion, anergy, regulatory T cells . Pathogenesis of autoimmunity: roles of susceptibility genes and environmental factors . Quiz. Emily Matthews (. e.k.matthews@warwick.ac.uk. ). Chris Lancaster (. c.j.lancaster@warwick.ac.uk. ). Jake Turner (. jake.turner@warwick.ac.uk. ) . Question 1. Define autoimmunity ( 4 marks). 1) . Auto. i. mmune . Disease Ontology. Alexander D. Diehl. 6/13/12. Neurological Disease Ontology (ND). Based on the Ontology for General Medical Sciences. Incorporates parts of NIF-Dysfunction. Three initial . Special thanks to Dr. Todd Watts DC . Barbara Stuart, APRN, NP-C, CEN. Integrative Medical Practitioners. Presented by . DoTERRA. Diamond Melody . Covino. Recommended Reading. Hormonal cycle of Thyroid. Mark S. Anderson, MD, PhD. UCSF. Disclosures. Research support from Juno Therapeutics. Consultant for . Sanofi. 2. 3. Lecture outline. Principles of immune regulation . Self-tolerance; mechanisms of central and peripheral . Immunotherapy. George Weiner, MD. Director, Holden Comprehensive Cancer Center. Professor, Department of Internal Medicine. George Weiner, MD. Disclosure. Consultant and Research Funding. Checkmate Pharmaceuticals. Iga. deficiency - description. Description:. Serum IgA <5 mg/. dL. Normal serum IgG and IgM. Patients >1 year . Genetics:. Autosomal Dominant. Abnormalities on Chromosome 18. Associated with HLA-A1, HLA-A2, B8, and Dw3 . For MBBS (29.09.2017). By: . Dr. . . Puneet Kumar Gupta. Assistant Professor, M. icrobiology. ,. Introduction. . Immunodeficiency . diseases. Defence . mechanisms of . body are impaired→ repeated . AUTOIMMUNE DISEASES. AUTOIMMUNITY. The . term autoimmunity refers to a failure of the body’s immune system to recognize its own cells and tissues as “self”, Instead immune responses are launched against these cells and tissues as if they were foreign or invading bodies. Dr. . Mayssaa. . Essam. Immunodeficiency . . . The . immunodeficiency may be the result of defective immunity, both innate and specific, because of . genetic. abnormality (. primary. ) or there is a loss of function because of the damage by . Immunodeficiency Diseases. Innate Immune System. Adaptive Immune System. Innate Immune system:. Physical epithelial barriers. Phagocytic leukocytes (Monocytes/Macrophages, . Neutophils. ). Dendritic cells.. LECTURE : 07 LEARNING OBJECTIVES : The student should be able to: Describe the term "autoimmune", indicate if it is either Define the term "autoantibodies". Determine if the autoantibodies eit Hypersensitivities. Hypersensitivity. Any immune response against a foreign antigen exaggerated beyond the norm. Four types. Type I (immediate). Type II (cytotoxic). Type III (immune complex–mediated). Immunodeficiency. = a disorder of immune system which manifests by impaired ability to carry out basic immunological functions, primarily defence against infection or immunological surveillance. Immunodeficies.