RubellaTyphoidliveTemperature sensitivity of vaccinesFreeze driedLiquid no adjuvantLiquid withalumadjuvantVaccine formulationRotavirusRotavirusHPVPneumoPCVinactivatedMeaslesOPVBCGHibHepBDTwPPentavalen ID: 885046
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1 Temperature Sensitivity of VaccinesMarch
Temperature Sensitivity of VaccinesMarch 2014 Rubella Typhoidlive Temperature sensitivity of vaccines Freeze driedLiquid, no adjuvantLiquid, withalumadjuvantVaccine formulation Rotavirus Rotavirus HPV PneumoPCV inactivated Measles OPV BCG Hib HepB DTwP Pentavalent T, DT, Rabies Yellowfever MenAPCV* Hib Leastsensitive ost sensitiveVaccines to the left of the line are not damagedby freezing Most sensitive Leastsensitive Heat sensitivity Freeze sensitivity HepA Influenzainactivated IPV MMR Varicellazoster virus DTaP Hexvalent MenCPCV*Th
2 e diluent forMenAPCVontains alumadjuvant
e diluent forMenAPCVontains alumadjuvantand is freeze sensitive. Cholerainactivated Not sensitive Heat sensitivityVaccineMost sensitiveOral poliovirusVaricellazostervirusInfluenza (inactivated, split)Inactivated poliovirusJapanese encephalitis (live)Measles, mumps, rubellaCholera (inactivated)DTaPDTwPDTaPhepatitis BHibIPV (hexavalent)DTwPhepatitis BHibpentavalentHib(liquid) Measlesotavirus (liquid and freeze driedRubellaYellow feverBacillus CalmetteGuérinHuman papillomavirusJapaneseencephalitis(inactivated)T, DT,dTLeast sensitiveHepat
3 itisHepatitis BHib(freeze dried)Meningit
itisHepatitis BHib(freeze dried)Meningitis A (polysaccharideprotein conjugate)Meningitis(polysaccharideprotein conjugate)Pneumococcal(polysaccharideprotein conjugate)RabiesTyphoid PS Vaccine sensitivity to heatAll freezedried vaccines become much more heat sensitive after they are reconstituted.Note: olded vaccines are freeze dried. Use vaccine vial monitors to monitor heat exposure. Freeze sensitivityVaccineMost sensitiveLeast sensitiveDTaPDTaPhepatitis BHibIPV (hexavalent)DTwPDTwPhepatitis BHibpentavalentHepatitis AHepatitis BHuman p
4 apillomavirusMeningitis C (polysaccharid
apillomavirusMeningitis C (polysaccharideprotein conjugate)Pneumococcal (polysaccharideprotein conjugate)T, DT, dTCholera (inactivated)Influenza (inactivated,split) Hib(liquid)Inactivated poliovirusTyphoid PSRotavirus (liquidThese vaccines are not damaged by freezing.Meningitis A (polysaccharideproteinconjugate)†Yellow feverBacillus CalmetteGuérinHib(freeze dried) Japanese encephalitis(live and inactivated)MeaslesMeasles,mumps,rubellaOral poliovirusRabiesRotavirusRubellaVaricellazoster virus Vaccinesensitivityfreezing Cautions:Ne
5 ver expose these vaccines to zero or sub
ver expose these vaccines to zero or subzerotemperatures.Avoid the use of ice for transport.Note: olded vaccines are freeze dried. While the stability data for liquid rotavirus vaccines demonstrate some resistance to freezing, the temperature handling recommendations in the vaccine product insert should be followed.The diluent forMenAPCVontains alumadjuvantand is freezesensitive. AbbreviationsInformation sources PATH, Working in Tandem. Summary of Vaccine Stability Data. Seattle: PATH; 2012. Available at: http://www.path.org/publicatio
6 ns/detail.php?i=1696 2. World Health Org
ns/detail.php?i=1696 2. World Health Organization. Temperature Sensitivity of Vaccines. Geneva: WHO; 2006. Available at: http://www.path.org/vaccineresources/files/Temp_sensitivity_WHO.pdf AcknowledgmentsThese slides have been adapted from an original slide set produced by Julie Milstien and John Lloyd at the Technet2006 consultation. BCG:bacillus CalmetteGuérinIPV:inactivated poliovirus vaccineDTaPdiphtheria, tetanus, acellularpertussisJE:Japanese encephalitisDTwPdiphtheria, tetanus, wholecell pertussis Men A:meningitis AHepAhe
7 patitis AMen C:meningitis CHepBhepatitis
patitis AMen C:meningitis CHepBhepatitis BMMR: measles, mumps, rubellaHexavalentDTaPhepatitis BHibIPV OPV:oral polio vaccineHibHaemophilusinfluenzaetype bPentavalentDTwPhepatitis BHibHPV:human papillomavirusPneumopneumococcalInfluenza: influenza (inactivated, split vaccine)PS:polysaccharidePSPCV:PSprotein conjugate vaccineT, DT, tetanus, diphtheria tetanus, diphtheria (lowdose) tetanus Extra slides for adaptation Rubella Typhoidlive Temperature sensitivity of vaccines Rotavirus Rotavirus HPV PneumoPCV inactivated Measles OPV BCG Hib He
8 pB DTwP Pentavalent T, DT, Rabies Yello
pB DTwP Pentavalent T, DT, Rabies Yellowfever MenAPCV* Hib LeastsensitiveVaccines to the left of the line are not damagedby freezing Most sensitive Leastsensitive Heat sensitivity HepA Influenzainactivated IPV MMR Varicellazoster virus DTaP Hexvalent MenCPCV Freeze driedLiquid, no adjuvantLiquid, withalumadjuvantVaccine formulation*The diluent forMenAPCVontains alumadjuvantand is freeze sensitive. Cholerainactivated Not sensitive Freeze sensitivity ost sensitive Temperature sensitivity of vaccines Freeze driedLiquid, no adjuvantLiqui
9 d, withalumadjuvantVaccine formulation L
d, withalumadjuvantVaccine formulation LeastsensitiveVaccines to the left of the line are not damagedby freezing Most sensitive Leastsensitive Heat sensitivity Hib Measles OPV BCG Hib HepB DTwP Pentavalent T, DT, TraditionalEPIvaccines Rubella Not sensitive Freeze sensitivity ost sensitive Temperature sensitivity of vaccines Rotavirus Rotavirus HPV PneumoPCV Freeze driedLiquid, no adjuvantLiquid, withalumadjuvantVaccine formulation LeastsensitiveVaccines to the left of the line are not damagedby freezing Most sensitive Leastsensitive
10 Heat sensitivity Hib Measles OPV BCG Hib
Heat sensitivity Hib Measles OPV BCG Hib HepB DTwP Pentavalent T, DT, “Traditional” EPI and newer vaccines Rubella Not sensitive Freeze sensitivity ost sensitive Temperature sensitivity of vaccines Typhoidlive Rabies Yellowfever MenAPCV* inactivated Freeze driedLiquid, no adjuvantLiquid, withalumadjuvantVaccine formulation LeastsensitiveVaccines to the left of the line are not damagedby freezing Most sensitive Leastsensitiv Heat sensitivity “Traditional” EPI and regionally specific vaccines Hib Measles OPV BCG Hib
11 HepB DTwP Pentavalent T, DT, MMR Rubel
HepB DTwP Pentavalent T, DT, MMR Rubella*The diluent forMenAPCVontains alumadjuvantand is freeze sensitive. Cholerainactivated Not sensitive Freeze sensitivity ost sensitive Temperature sensitivity of vaccines Rotavirus Rotavirus HPV PneumoPCV Freeze driedLiquid, no adjuvantLiquid, withalumadjuvantVaccine formulation LeastsensitiveVaccines to the left of the line are not damagedby freezing Most sensitive Leastsensitive Heat sensitivity Hib Measles OPV BCG Hib HepB DTwP Pentavalent T, DT, MMR HepA Influenzainactivated IPV Varicellaz
12 oster virus DTaP Hexvalent MenCPCV“
oster virus DTaP Hexvalent MenCPCV“Traditional” EPI, newer and middleupperincome country vaccines Rubella Not sensitive Freeze sensitivity ost sensitive Temperature sensitivity of vaccines Freeze driedLiquid, no adjuvantLiquid, withalumadjuvantVaccine formulation LeastsensitiveVaccines to the left of the line are not damagedby freezing Most sensitive Leastsensitive Heat sensitivity HepA Influenzainactivated IPV DTaP Hexvalent MenCPCVMiddle/upperincome country vaccinesVaricellazoster virus Not sensitive Freeze sensitivity ost