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mTOR. Furthermore as mTOR is widely expressed rapamycin a macrolide antibiotic produced by Streptomyces hygroscopicus is recommended in patients presenting neoplasia due to its antiproliferative actions Hence we have investigated whether rapamycin presen . Presentation. July 2015. OTCQX: RESX. This presentation includes "forward-looking statements" under the Private Securities Litigation Reform Act of 1995. All statements other than statements of historical facts contained in this presentation, including statements regarding our anticipated future clinical and regulatory events, future financial/position, business strategy and plans and objectives of management for future operations, are forward-looking statements. Forward-looking statements can be identified by words such as “potential,” "may," "will," "should," "forecast,“ "project," "could," "expect," "believe," "estimate," "anticipate," "intend," "plan,“ “continue”, other words of similar meaning, derivations of such words and the use of future dates. Forward-looking statements in this presentation include, without limitation, statements regarding our current business strategies, the potential future commercialization of our product candidates, potential estimated market sizes for our product candidates, anticipated start dates, durations and completion dates, as well as potential future results, of our future clinical trials, anticipated designs of our future clinical trials, and anticipated future regulatory submissions and events. Uncertainties and risks may cause actual results to be materially different than those expressed in or implied by our forward-looking statements. Particular uncertainties and risks include, among others, uncertainties regarding our ability to license out our existing and license in additional products and technologies and the terms of such licenses; uncertainties involved in clinical testing, the difficulty of developing pharmaceutical products, obtaining regulatory and other approvals and achieving market acceptance, and other risks and uncertainties described in our filings with the Securities and Exchange Commission, including our most recent annual report on Form 10-K/A, subsequent quarterly reports on Form 10-Q and final prospectus dated July 31, 2014. All forward-looking statements in this presentation speak only as of the date of this presentation and we undertake no obligation to update or revise any forward-looking statement, whether as a result of new information, future events or otherwise.. Dr. Tory Hagen. Lipoic Acid Induces Nrf2 Activation in an mTOR-dependent Manner. Young. Old. Oxidative Stress . Response Systems Decline with Age. Influences the expression of . over 200 genes with the. Cell death. Necrotic. Caspase-dependent. Caspase-independent. receptor. -caspase 8. mitochondria. -caspase 9. Classification of cell death. Apoptosis. Apoptosis is programmed cell death, which prevents damage to neighboring cells by controlling how the affected cell dies. increased hypoxia-inducible factor transcriptional activity and a loss of. metabolic flexibility. Dr. Andy Tee . Cardiff University (Medical Genetics) United Kingdom. Cowden’s Syndrome. Birt-Hogg-Dub. BAD,Bcl-2-associateddeathpromoter;GRB2,growthfactorreceptor-boundprotein2;IRS1,insulinreceptorsubstrate1;MDM2,murinedoubleminute2;mTOR,mammaliantargetofrapamycin;PDK1,3-phosphoinositide-dependentprote Failing to cure the majority of advanced solid . tumours. Declining therapeutic benefits at higher drug . cost. Drug resistance highly complex: . Approx. 10% of kinases alter resistance to one or more drugs . Abbreviations:ADPKD,autosomaldominantpolycystickidneydisease;cAMP,3-cyclicadenosinemonophosphate;mTOR,mammaliantargetofrapamycin;PCLD,polycysticliverdisease;TAE,transcatheterarterialembolization;VEGF, Buparlisib. and . Fulvestrant. in Postmenopausal Women With HR , HER2–, AI-treated, . Locally Advanced or Metastatic Breast Cancer, Who Progressed On or After . mTOR. Inhibitor­-based Treatment. GHRELIN SIGNALING PATHWAY - SHRADDHA D. REGE Ghrelin Is a 28 amino acid Orexigenic peptide and hormone. Director, Pediatric . Neuro. -Oncology. Hackensack University Medical Center. Tuberous Sclerosis Complex. and Seizures. “Knowledge is Power”. What is TCS?. Neurocutaneous. disorder. Neurologic structures and skin are derived from the same tissue in the embryo. AllinhibitorsJTP-74057PD325901GSK2126458BEZ235GDC-0941PP242rapamycinGSK690693andPD0332991werepurchasedfromSelleckChemicalsandChemieTekSchematicinteractionsitesforthespeci3cinhibitorsaredisplayedinFigS cyclin. and PI3k pathways. UKMF Spring meeting 2015. Kwee Yong, UCL Cancer Institute. Not one, but many myelomas. Dysregulation. of D-type . cyclin. in multiple myeloma. Early oncogenic events . dysregulate. th. 2015. Radio-immunotherapy of cancer. Therapeutic efficacy, underlying mechanisms and potential applications. Paula . Kroon. , . Nicole Haynes, Victoria . Iglesias-. Guimarais. , . Ricky . Johnstone.