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Vol. 7, No 1 &2 Jan-JuneIJuly-Dec 2004 Saima Obaids et a1 Med. Univ. axilla elsewhere. Perineal imperforate hymen bluish, bulging vascular protruding from introitus. initial ultrasouad of pelvis and abdomen, vagina and uterus was dilated with fluid. These & haematometra. The per deciliter, white blood eosinophils. Urine analysis normal. erythrocyte sedimentation in first The ultrasound revealed urinary tract anomalies. The patient and her family were counselled for the surgical Hymenectomy the procedure of choice. risks and benifits the procedure explained and informed consent was obtained. Hymenectomy was performed cruciate incision at 2,4,8 and 10' clock position avoiding to the urethra vaginal epithelium sutured to the hymenal orifice using interrupted stitches with five absorbable Polyglycolic suture). For post operative analgesia, lignocaine jelly was the suture line. During Hymenectomy 450 of brownish blood was drained from the vagina and uterus steroidal anti inflammatory

drugs family were counselled that clotted blood would from the for several days. She was instructed to report to taking medicine. She was informed that the absorb. The first follow up visit was done after days. She complained of a slight brownish discharge the pain subsequent visit, on the day there were no symptom. Her vulva inspection revealed the same visit counselled to take contraceptives for that menstruation would mucous membrane the junction sinovaginal bulbs with urogenital sinus. It fiom urogenital sinus epithelium. Tt perforated during embryonic life usually tom during coitus1. Hymen there are through this membrane. Imperforate hymen uncommon vaginal anomaly usually to 15 years of This is consistent with report. Mostly patients consult a gynaecologist when symptoms appear and menstruation does not For the two cycle blood accumulates it distends it causes slight discomfort & blood accumulation, cavity becomes distended blood, (haemotometra). In extreme conditions there retrograde flow

into fallopian tube (haematosalpinx). Adhesions may occur in fallopian which prevents flow in peritoneal cavity otherwise it In our case initial were cyclical lower abdominal pain, discomfort pelvis, backache and lower abdominal These were followed grade intermittent wig literature athough fever is unusual presentation. present in urinary retentions. This was not observed our patient. Reported familial cases of imperforate hymen Lim7.Family evidence of imperforate hymen Vol. 7, No1 & 2 Jan-June 1 July-Dec 2004 SHORT COMMUNTCATTON Therapeutic Tumour Lysis (degeneration) THE autonomous growth of malignant tumorous outgrow its blood supply and causes central degeneration of the tumour, but it is not enough to eradicate it. The measures taken to accelerate tumour degeneration (lysis) can be used to wipe out the tumour. Chemotherapy partially disintegrates tumour cells, but it is all temporary, any process which liquefies tumour cells by proteolytic substances can start a chain reaction of degenera

tion. Tt is manifested by fever, malaise and shrinkage of turnours. According to Cone's theory (1988) accumulation of lactic acid in the center of tumours is deleterious. This can be achieved by following certain dietry regime for example acts J. Baqai Med. Univ. in two phases by recurring bioflavinoid quercetin. Fifty (50) percent or more of solid tumour are under the category by manipulating metabolic pathway thus affecting tumour lysis. However, when cell incurs damages, viz., exposure to ionizing radiation, toxic agents like p53 gene allowing cell degeneration. Oxygen deficit can be induced in interfering angioplasis. Anti-angiogenic drug like the thalodimide and shark cartilege extract show in chain reaction of hunour lysis. My personal experience of injecting liver tumour produce intra-tumour injection of concentrated saline. This can introduce a new avenue for cancer therapy in hre, especially in an inoperable cancer at delicate sites. Rafiq Ahmed Mirza. Medical University