et̄l.܈lआif r܍t܎ll.܏P܏ - PDF document

et̄l.܈lआif r܍t܎ll.܏P܏ܑ਒la܊ጇp༔v༄d༂ܕdPPIl܈lअtl.༃dਂD mB܎༂dlaܚrਆ yI,l.ᰍPਆ܎.ܑ༆̍tܝIEC Vt̆਒IE̍ਂ eȃЅ؇ԈЉԊ؋అഉଇ؋ugsԐpԈЉԇPgAsԆ܅ଉጉᄉଔnPogԖPؒؓᜅДmԖggᄅPᄕgmnPጔngs ȘPᄓԆଓvᄐmumԘȃЅvmԈЉԔᤆA؈AyԛAnІȓaԈЉԔᤆA؈AԐmԃvഔᘒgԆ܅ଉጉᄉଔnPᄓ APuᘘԈЉଉԐmԔԃؑmP༉ଔᘒgԍaDAؓgpgnP ԏPmnvᄃgԖgniggpԔuഄPIPvᄘԔᄏ uvuuvAmyԜАmԍvഉfԃؑmP༉ଘԈЉԔᘐAPnDԆ܅༉gଅn.ԋgᴓଆiԔᄈAgଘԔmԔԘDmnguԆR uvuuvAPvpԈPmmȉԋgጉᄉଔnPؑԈДnl uvᜅДᔉԈЉଔഉȈP ԍ؈gᄈPvAy et̄l.ܡrltਃB,lP܏tAܘlr༜dਖ. ,ᄈAgଘԔଉԃȋP؂mԘnଂ nȋgmyԞᄒPఉԄ؋ᄘἅiА ЅvଉԌgଔnPᄐmgsԈPmmȉԓଆiPᄓ ܋؎Ԕᄅȑ༉଒DPpcԎgmgᄃaDuvAԃgAAԒvDgfCԔᄈAgଘԔଉԆଓvᄘᨅHЉᜅДᔉԖA؆s ᔉmmgAmἅᄉକgmἅmఐᄟԃvଈPAvጉԔᄏԖؑgἅvᄏԓଆiԂᄏgଅmnଐ nԉᄏ؃ଐᄉԃؑnଆAy HЉᜅvଉԘЉ༅gv aԗgvଟԍଆᔐ༐ᄓԈЉԆᄒᜅgᤔudAgԆ܅؋ጔᄅ؋ԒPuIԋgጉᄉଔnPؑԐp uvuuvAmyԠȋnЉ଎؋gCԈЉԃ؋ଉ nԘP጑vAmԇ؋ԔᄈAgfԏgᔉA؍ugᄈԔଉԆᄒDԈȋᄉsԆp vnԍȖgଈDyԜЂmԈЉᜅvଉԈЉԆᄒDԉᤔuഒgԆ܅nЉԏgᔉA؍ugpnԆ܅vᄅ؋ጔpԈДnԐm ༉AvDgsԡJଐ gl et̄l. Jdख.lܣD ԧ؋nЅ,ugfP vpԨgPᄏggfCԊPnЅAvfጉCԄPcВᜅᘋvᄃЉsԕgAᔉnԃؕgfgsԔᄈAgfmyԩfg༐nԪgvp 8PጓPᄘCԄnnബPuvcgmyRimᨓؕԞᨭᨅVPmЅ9ԯPA༒PRgԭgfᔐ g԰P gp g(ԢȖAP Ԫ؎vPp ,ᄈAgଘԔଉԂᄐ㄂gԈ؅༉gଟԖȈԑ؈ԔAAԘഉ PgmԄvᔉԈЉuCԑ؋ԐmԈЉPfԖPؒؓᜅnЉԘvug v ଆmmԈЉԘഉ PgmyԨgPᄏggfԡ RЈऊfer̂ЌЈഎs ☟ԇ؋ԉᤔuഒgCԔଉԈЉԆᄒᜅmഉ PgmԐp iА aԈЉԇguvAgmԏgᔉA؍ԔᄈAgଘԡ3gጐgAmఐl et̄l؃ ,ᄈAgଘԃ؎gԐpԎvpᜅmДഉmԔᄏԘPzgmCԇଆuԔԇgiԃgᄈPugnଉmԒؑጅPpԈЉԅം༂ Pญȗญa ★n؅nЉԎv጑Pܐ gᄈԍvAuvngsԔᄈAgଘԂഅn.ԳᨥԎgnଉmԐᄅAgᄓnaԐᄅnЉ u؆mgԡ Alces̄lces ★™ଐ gl et̄l. ,ᄈAgଘԂmȔAAᜅᘉጐpԈ؅ጋ؊ԐᄅnЉԘഋPᄓԆ܅༉g଴mԘg ؑ༅DgvfCԖȈԎ؆mgCԋ؉C iАnghnvPAgsԔᄏԎȒgԏggଅܔiᄘԎvᜅഋ؏ȃgԈPᄗԔᄈAgଘԏȋPᄓԈЉPଅܐଘnԔȈȎᄟ iАAmnԋgPᄏggfԃvAᔉmԘnvଈԈ؅ጋ؊ԔᄈAgଘԊPnАpԊggఘԆ܅ᘉPᄓԖ؋ᄅ™Ȉuvᄟ evpDԎvuuvAPvpԘഉ PgmԄvᔉԉᔆAᔉ༅mDmngumԆ܅uvm tAPᄉԃ؎ഉnPnPؑԊА a uPpPuPmgԍЗmP vAԏvuvጉCԘȃaԔmԈЉԉmnvᘒPmaugᄈԆ܅༆uPᄔp gԍȋgAᜅᘗԏPmഒvDy HЉԘPzgԆ܅vᄈAgଘԍvଈPvAAᜅ༉ngfuPᄉmԘnଉᄓnaԊPnІȈԈЉԑggsԇ؋ԕPؒgᄃgyԜЂmC vᄈAgଘԔଉԃؑ༐nPؑh༉ഉᄏgᄈԐᄏP vn؋mԆ܅ܐnᄉmmἅPpԔ༏PnPؑԈ؅nЉPfԍଔ nP vAԋؒg ܆ଅഋ؈g nPؑԔጔPᄘnԍଉ༔n؋mԡ,ᄏgଘmؑἅ⌤␷★ ™ȈuvᄟԳ㔶㘦y et̄l.ܤ.if r܏tA܎lᰅaਛvlt JgଐؘngtuԐmԔԈА rԎguIଔᄉԈДnԃؕgଘԈЉԘȋܔ gԆ܅ᘆᄉmᨅOmngؖAvmnmԡ gAAm nДnԏgᔉA؍Ԑᄈ.Ԗؑg★vᄏԆnЉfԃgAAmԐuആଈvpnԐpԈЉԎvPᄈgᄔp gԔᄏԋgഔPଅ؇ ᘆᄉCԔଉԔmm؃PvngsԊPnЅnЉԍgଐؘngȎyԛᄈAgଘԏgᔉA؍ԇଆuԍg༐ AgmԡnЉԖvmg ܋؎ԊА aԈЉԔᄈAgfԓଆim★ؑԈЉԇଆᄈvAԖؑgԆ܅nЉԘంAAԇଆuԔᄈAgଆጉᄐ ഉଐؘngtuԡ,J★ℹ.mmԔᄏԢ؊gAAἅ㌵㘥☚Ԣg༐ AgmԏgᔉA؍ԐᄅnЉԎvAgmԔଆȑ༅nЉ nPugԆ܅ംᘉଈDyԨPmPᄓԔᄏଆጉpԒgᔉAmԐᄅnЉԖA؆༅v nPᔔngԍgଐؘngvAԃgAAmԐpԍvଈԆR nЉԇଆᄈvAԖؑgԆ܅nЉԘంAAԈ؅܆଎ԈАmԈPmmȉᨅHЉԐᄐnPvAԘnvጉԆ܅༉ᔉA؍ugᄈԐm Дଔ ngfPmgsԖDԈЉԏP܇gଉᄈPvnPؑԆ܅vᄈAgଆጉᄐ ԃgAAmԐᄈ.ԆmngؖAvmnmyԯЉpԈЉ ഉ༐ AgԐmԖgniggᄅ┅vᄏԳ┅uPAAPugnଉmԐpԄgPጄnἅ vଈPAvጉԐmԇ؋ugsԊА ЅؘmPܐgm ℰPԔᄏԭȈnPgCԳ㔵㨦ᨅ HЉlvᄑȔAlଉጉᄉଔnPؑl؇lvᄈAgଘlᘉጐᄘlPplgv଒DlmȎugfliЉpl܆؏lPmlഒgᄈP܂AylHЉ ଉጋ؊nalഒv gmlvlЂጉlmnଔPplؑlnЉlvᄐuvA㐘luPpgଔAlଉmgକgmCliPnal㬤ఓl؇lᘆᄉ ጋ؊PᄓlPpljȘnlȑ༉flnЋggluؑnИylHЉlmఉAgnؑlȑ༉ଓ؉mlvlഋ؃gmml؇l“ D AP ଉᔉଘPᘒgԆmng؍؋ؘPm”Cl؃ ȋଐᄓԎؘnlᄆnvᘒᜅPᄅᄆᄝigPጄnlᘉvଐᄓԖؑgmCԘȃaԔm nЉlଐᘘlÅȖgᄐటl㌵㘻☚lGPᔉplnДnlnЉଉlPmlᄆlଉm؋ഈPؑl؇lnЉlvᄈAgfl℔ഔଈl܋؎lv ᄉጒPጐᘒglvu؂pnlvnlnЉlഉ༐ Aglᘉ܆ଉlmЉ༏PᄓSlnЉlmnvclДmln.lଉഒv glnАml㄂vᄈPnD ؇ԈPmmȉԔᄏԎPᄉଔAmԉv aԗgvfyl 㼑lnЉlmȎugfluؑnИlmnvጘlvଉlଉഋ؏ȃnPᔉADlPᄔ nPᔉClvᄏl PଃȒvnPᄓlngmnؘngଆᄉ AgᔉAmlvଉlA؊lℹ.mmCl㌵㘻☟lmȓጉmnPᄓlvᄈAgflଉጉᄉଔnPؑlPmlȑ༉flᄆᄝጆᄔ༔A ؑnଆAyl㼹VᴳClvlug༐vn؋l؇lጋ؊nalІ଎ؑgClmDᄈagmPmgslPplnЉlAPᔉଟluvDlᘉlnЉ ؑnଆAAPᄓlPᄇAȉᄃgyl㼹VᴳlPmll PଃȒvnPᄓlPplАጄl ؑ gᄈଔnPؑmlvnlnАmlnPuglℭȈnPg et Ѕ. ㌵㘥☟lIGVlଉ gഈ؋ml vplᘉl܆ȑslPplnЉlጋ؊PᄓlnPdl؇lnЉlvᄈAgfl⅀AAP؈nl et Ѕ. ㌵㔻★vᄏԿGVmԄvᔉԖggpԘggᄅn؅ഋ؎؈gԈЉԍଆAP܉ଔnPؑԆ܅vᄈAgfԃgAAml in̔itro Jdख.lܥ ᨅ3vfPᘆȅvᄈAgfmԑgvf :ؔnvrԨPᔉfἅ )gAviPఅ:vnPؑvA 7PA༒PRgԨgRȓgCԛAvmఔyl 3fg༐nἅJ.Թؒ༎vᄑἅ EᨭᨅVPmЅ9 7PA༒PRgԭgfᔐ gl :P gp g(ԢȖAP Ԫ؎vPp )Љ༏Pᄓl؋l vmnPᄓԆRԈЉԔᄈAgଘlᄆ଎vAADԆ ȋmԉᔉfᜅDgvfԐpliPᄈgfԆfԉv଒DԘഋPᄓ vᄏlPmlȑ༉flnЉl ؑnଆAl؇lnЉlmgBlmngଆP༟lngmnؘngଆᄉylHЉl PଃȒvnPᄓlAgᔉAml؇ ngmnؘngଆᄉl ДᄓglPplଉmആᄘgln.lPᄃଉvmPᄓl༔DAgᄓnКl,ᄈAgଘlvଉltmȔAADl vmn iPnАplvl༔Dl؋lm.l؇lgv al؈ЉଟlvᄏlnЉlഋ؃gmmlPRlᔉfDlnPጄnADlଉጂAvng༚lOmng؃Avmnm ℒvଓgluȒnPᄂ Agvngl gAAmlnДnlଉm؋Il vA PRPgslᘆᄉSlଉm؋IlᘆᄉlPplnЉl༐mnvAlഉ༐ Ag ℈Љԋ؆nԆଅᘔmgԆ܅nЉԔᄈAgଦԃvȘPᄓԈЉԔᄈAgଘԈ؅ᘉԘЉsԡGؘmԔᄏԢ.igAAC et̄l.܈lअtl.༃dਂ܏tAܝdvS܎lᰅaਛvlṫ ,ᄈAgfԋgጉᄉଔnPؑԔ഍gvଘԈ؅ДᔉԎ؋gԘPuPAvଐnPgmԊPnЅnЉԏgᔉA؍ugpnԆ܅APuᘘ PpԔԎvuuvAPvpԇ؉nȘԈДᄅiPnЅnЉԋgጉᄉଔnPؑԆ܅nЉԒPuIԆ܅ȋ؏gAgmyl ,ᄈAgf ଉጉᄉଔnPؑԐᄕؒᔉmԈЉԏgᔉA؍ugᄈԆ܅ᘆᄉἅ vଈPAvcgCԘఐᄟԑgକgԈPmmȉԔᄏ ᔔm ȒvnȋgԇଆuԈЉԔᄈAgଆጉᄐ ԍgଐؘngȎԡ,J★iА ЅuvDԖgԍؘnᄔnvAADԋgnvPᄉs guᘋDؑP ԈPmmȉԡ:PԔᄏԭȈnPgCԣ␤㌦y :PԔᄏԭȈnPgԡ⌤␳★mȓጉmng༅mPuPAvଐnPgmԖgniggᄅnЉԃ؎ഒgBԋgጂAvn؋ᜅഋ؃gmmgm ᘉАᄏԒPuIԔᄏԔᄈAgfԏgᔉA؍ugpnyԜଔᄘഒvᄈvnPؑԆ܅ᘆnЅ:vngଔAԢAvngԁgm؏g଎ ℰJe★PᄅuP gԇଆuԊА ЅAPuᘘԏgᔉA؍ԔᄏԈЉԔᄈAgଆጉpP ԍgଐؘngtuԡ,J★Pp ༉gfԋgmȒnmԐᄅnЉԏgᔉA؍ugᄈԆ܅APuᘘԆଅvᄈAgଘCԋgmഉ nPᔉADyԫ؈ЅAPuIԖȏԔᄏ vᄈAgfԍg༐ AgԏgᔉA؍ugᄈԘnvଈmԊPnЅ gAAԍଆAP܉ଔnPؑԇଆuԆᄉԇ؋uԆ܅guᘋDؑP nPmmȉԈЉԎgmgᄃaDugԡ:PԔᄏԭȈnPgԳ㔵㨦ᨅ,JԃؑnvPᄘԔAAԈЉԐᄇ؋uvnPؑԇ؋ԔᄈAgf ༉ᔉA؍ugpnԐᄅnЉԘvugԊvDԈЉ԰Jeԏ؉mԇ؋ԒPuIԏgᔉA؍ugᄈԡ:PԔᄏԭȈnPgC OᄉԆ܅nЉԎvPpԔጋggugᄈmԐᄅnЉԇPgAsԆ܅vᄈAgfԋgmgvଃaԐmԈДnԈЉԔᘐAPnDԆ܅nЉ vᄈAgfԈ.ԋgጉᄉଔngԐmԄgAsԊPnАpԈЉԉᄈPଉԍg༐ Agԡ:PԉnԔAyԣ␤䈦ἅvmԈଔᄘഒvᄈvnPؑ gᤍgଐugpnmԄvᔉԘІiᄚՃ؊gᔉଟԐnԊvmԑ؈ԌᄆiᄅiА aԘഉ Pܐ ԈPmmȉԇଆuԈЉ ഉ༐ AgԊvmԋg㄂Pଉsԇ؋ԋgጉᄉଔnPؑCԑ؋ԊvmԐnԌᄆiᄅiЉnЉfԋgጉᄉଔnPؑԊvm ༉ഉᄏgᄈԆᄅnЉԐᄈgଔ nPؑmԆ܅༐܇gଉᄈԈPmmȉԈDdgmԖgniggpԈЉԖؑgԔᄏԈЉ ؕgଐᄓԘఐᄚ԰PԉnԔAyԣ␤䈅༉ng଎PᄉsԈДnԈЉԍg༐ AgԖؑgԔᄏԑ؈ԈЉԍg༐ AgԘఐp ivmԈЉԈPmmȉԓPᔐᄓԋPmgԈ؅nЉԋgጉᄉଔnPᄓԔᄈAgଟԔᄏԈДnԈЉԐᄈgଔ nPؑmԖgniggp nЉԘఐᄅvᄏԖؑgԊgଉԕPnvAԇ؋ԋgጉᄉଔnPؑCԖȈԆᄒᜅPᄅvԍଐuPᄓԃvഔ PnDyԜЉ ഉ༐ AgԘఐpԍAvDgsԑ؅ଆAgԐᄅnЉԇؒA؊PᄓԋgጉᄉଔnPᔉԍଆ gmmԡ:PԉnԔAᨅ⌤⑂☚ p਄lEIa༆ܡ༃rf༙P܍tᰊaᰅA܍t܁t̄l.ܤ.if r 4P܇gଉᄈԃЉuP vAԘP጑vAmԐᄈgଔ nԈ؅܆଎ԔᄅvᄈAgfԇଆuԈЉԉuᘋDؑP ԒPఉԈPmmȉԆR nЉԍg༐ AgyԜЉଉԐmԔᄅPᄃଉvmPᄓԖ؏DԆ܅gᔐ༉ᄃgԘІiPᄓԈДnԈЉԎؒg Ȓvf ଉጂAvnPؑԆ܅ଉጉᄉଔnPؑԐpԔuഄPIPvᄘԔᄏԔᄈAgଘCԔଉԋg vഐnȒvnPؑmԆ܅ഔnЊvDm PᄕؒᔉsԐpԉuᘋD.ᄐ ԏgᔉA؍ugᄈԡe؂ᄈl et̄l؃ HЉଉԔଉԎvpᜅmP጑vAAPᄓԍvnЊvDmCԔ nPᄓԖ؈ЅA؃vAADԔᄏԘDmnguP vAADCԔ nPᄓԆp mnguԔᄏԍଆጉᄐn؋ԃgAAmԈ؅ഋ؏ȃgԔᄅ؋ጔᄚԜi؅Puആfnvᄈԇv n؋mԡvuؑcԘgᔉଔA ؈ЉଘSԔଉԋgnPᄆP Ԕ P༅vᄏԍvଔnЗଆPsԄ؋uؑgԋgAvngsԍgഈP༉y NgnPᄆP Ԕ PsԡN,★ଉጂAvngmԘఉAgnvAԏgᔉA؍ugᄈԔᄏԋgጉᄉଔnPؑԐpԂଆ༉Ag vuഄPᘐvᄘԘȃЅvmԈЉԔᤆA؈Aԡ) v༏PᄓԔᄏԁv༉ᄟԳ㔵㨦ᨅ ᘈ̔ivo mnȏPgm ഉଇ؋ugsԐᄅnЉԳ㔵␘ԍଆᔐ༉༅gᔐ༉ᄃgԈДnԉᤆጉᄆȘԨ,Ԕ഍AP vnPؑԐᄇAȉᄃgs nЉԏgᔉA؍ugᄈԆ܅nЉԇPଘnԔᄈAgଟԔᄏԒgsԈ؅v gAgଔnPؑԔᄏԔAngଔnPؑԆ܅nЉ ༐ଉ nPؑԆ܅nЉԓଆinПԊАAmnԐᄃଉvmPᄓԈЉԕؒtugԆ܅nЉԍଐuvfDԔᄈAgfԡKPgଏ؋R vᄏՄPgଏ؋ܟԳ㔵㘦ԡKPgଏ؋RԔᄏԫvଈؘCԳ㔵㔦ᨅVPᄏPᄓmԍȖAPmЉ༅IDԛAAgpl et̄l. ℣␤⌦ԃؑܐfugsԈЉԋؒgԆ܅N,ԐpԈЉԋgጂAvnPؑԆ܅ gAAԏP܇gଉᄈPvnPؑԐpԈЉ ጋ؊PᄓԔᄈAgଚ԰gᔉAmԆ܅N,ԊgଉԎgvmȋgsԐᄅvᄈAgfԈPmmȉmԏȋPᄓԔAAԈЉԘnvጉmԆR ༐܇gଉᄈPvnPؑCԔᄏԊgଉԃ؎ഔfvᘒgԈ؅AgᔉAmԇ؂ᄏԐᄅ༉ᔉA؍PᄓԒPuIԖȏmԔᄏ ଉጉᄉଔnPᄓԂଆ༉AgԒPuᘘԡJଐ gԔᄏԛAAgᄟԣ␤㨦ԡ) v༏PᄓԔᄏԁv༉ᄟԳ㔵㨦ᨅN, uvDԔAm؅ଉጂAvngԈЉԉv଒ᜅmnvጉmԆ܅vᄈAgfԋgጉᄉଔnPؑԔnԈЉԘPngԆ܅i؂ᄏԄgvAPᄓ ™ଐ gԔᄏԛAAgᄟԣ␤㨦y JvଔnaDfؐslІ଎ؑglଉAvngslഉഈP༉l™HHଢSlഒvDmlvplPuആଈvᄈlଆAglPplvlᄂuᘉfl؇ ༉ᔉA؍ugpnvAlmDmngumyl ᘈ vivo u؏gAmlȘPᄓl఑؃ఆȈluP glДᔉl ؑܐ଎gslnДn JHHଢlPmlgmmgᄈPvAl܆flnЉl༉ᔉA؍ugpnl؇lvlᄆ଎vAlᘆᄉluvmmlw,uPzȌvl et Ѕ. , nPᄓlnЋ؂ጄlPnmlଉ gഈ؋lwJJN☟lPnlଉጂAvngmlnЉl༐܇gଉᄈPvnPؑl؇l gAAmlnДnlvଉlnЉ ഋgh ȋm؋ml؇l vଈPAvcgClnЉl Іᄏଆ DngmClPplnЉl༉ᔉA؍PᄓlmఉAgnؑl⅄ଆᄉᄖgଓC 㼑lvᄈAgflmnȏPgmClJHHଢlДmlᘉgplmІipln.lPᄃଉvmglഋؒP܉ଔnPؑlvᄏl༉ ଉvmg ༐܇gଉᄈPvnPؑԆ܅ Іᄏଆ Dngml℠vȃЉșlvᄏlJଐ gCl⌤␳★vᄏԢHHଢԐmlgᤍଉmmgsԐp АጄlAgᔉAmlPplnЉlnPmmȉml܆଎Pᄓl vଈPAvጉlPplvᄈAgଘlwJଐ glvᄏl,AAgᄟl⌤␺☚l,ᄈAgf ؘngؖAvmnmlvAm.lgᤍଉmmlJHHfJlvᄏlPnmlଉ gഈ؋ClmȓጉmnPᄓlPnlДmlvlଆAglPplnЉ ଉጂAvnPؑl؇lnЉl༐܇gଉᄈPvnPؑl؇lؘngؖAvmnmClvplP༉vlmȍആଈgslIDlmgᔉଔAl in vitro u؏gAmԡJଐ gԔᄏԛAAgᄟԣ␤㨦y JI̖.l܎lᰅaਛvlt̐ ,ᄈAgfԋgᴓଆinЅv഍gvଘԈ؅ଉAᜅȍؑԈЉԎvPpngᄔp gԆ܅vpԉuᘋD.ᄐ ԒPఉԘgnԆR gAAmԊPnАpԈЉԍg༐ AgԈДnԔଉԘംଋg༅Pᄈ.Ԕ nPؑԆᄅvᄅvᄑȔAԖvmPmԖᜅvԃPଃȒvnPᄓ ጋ؊nЅܔ n؋yԛԃ؃ఈvPAԆ܅A؃vAԄ؋uؑgmCԍଆngPᄘԔᄏԆnЉଅጋ؊nЅܔ n؋m uvPᄈvPᄘԔᄏԏPଉ nmԓଆinКԜЉԃДAAgᄓgԒPgmԐᄅȑ༉ଘnvᄏPᄓԈЉԊvDԐpԊА a vAAԈЉԏP܇gଉᄈԘP጑vAAPᄓԍvnЊvDmԐᄈgଔ nԈ؅܆଎ԔᄅvᄈAgଚl nlጅ.ltElP ,AAgpԭyJ᨟ԁv༉pԁᨅvᄏԢଐ gՁy)ᨅ℣␤⌦ԛԋؒgԇ؋ԋgnPᄆP Ԕ PsԐᄅଉጂAvnPᄓԈЉ ଉጉᄉଔnPؑԆ܅༉gଅvᄈAgଘyl DevelᔑmeࠂЅ̙iᔅᔉy, (Ժ␵ᴺ⌻y ,uPzȌvԧ᨟ՃgᄏgଘؑՁᩀ᨟ԯАngՁᩃ᨟ՄvଔഒPmԛᨩ᨟ԹؒnzuvpԪ᨟ԭvmvఐἅHԔᄏ OzvivՃᨅ℣␤␦Ԩg gᄈԭnȏPgmԆᄅnЉԖPؒؓP vAԔ nPؑԆ܅JvଔnaDfؐsԄ؋uؑg ™HH☝ԋgAvngsԢgഈP༉ԡJHHଢ★vᄏԈЉԢHH/JHHଢԋg gഈ؋ԐpԃvଈPAvጉԔᄏԖؑgy Histᔅᔉȳࠍ̜istᔑЂᴕlᔉy, (㔥䈝㕂␚ ,ᄏgଘmؑԁᨅ℣␤㜦ԩؑ༐nPؑh4gഉᄏgᄈԿᄏP vn؋mԐᄅ)gᤂvAԭgAg nPؑ( 4gᔉA؍ugᄈԆ܅HЉ؋ᜅvᄏԜgmnmᨅ EssКs̊n̒ࠊmЅ̙eᴄviᔎr, :ȃvmՁᨨᨅvᄏ )Puu.ᄘ԰ᨯᨅ℉༘ᨦἅEAmgᔐgfԛ v༉uP Ԣଉmmἅ:giՆ؋చ 8ȖgᄐrԹᨅℳ㔶㬦ԜЉԉᄏ؃ଐᄉԋgጂAvnPؑԆ܅nЉԔᄈAgfԃD Agyl Aࠂler̗evelᔑmeࠂ in̟erviഄe؃ 8ଆiᄅNԡg༚S 3gጐgAmఐԁ᨟ԩvAఆmPᄘఐԿ᨟ԪzPgጐgAԢ᨟ԹgᘔଆimఐԜ᨟Ԣ؏ІfmఔhOఆA؊ԁ᨟ )ఔAPrԨᨅvᄏՇvᘉAԁᨅ℣␤┦ԭgvଃaԇ؋ԭnguԩgAAmԐᄅnЉԹଆiPᄓԛᄈAgfԭnvc Cervฏ́lБᴎs Bฅletin̕f̂ᴁ̠eteriࠄry̖ࠏtitขe̕f̐ฅСy, (ԣ㩂ᴣ┳y EAAP؈nՁᨰ᨟ԸA༄vuՁyeᨅvᄏԛuᘒgfԹᨨᨅℳ㔵㬦ԢଉmgᄃgԆ܅nЉԐᄘȒPᄝAPఉԓଆina ܔ n؋h㌅ଉ gഈ؋mԔᄏԔᘘgᄃgԆ܅nЉԓଆinЅІ଎ؑgԋg gഈ؋mԐᄅnЉԔᄈAgfԈPച Eࠍᔓriࠕlᔉy, (⌥㌻h⌥⌤y VvȃЉșԩ᨟ԧgmᘐnnԭᨛ᨟Ճ؋nؑԁᨛᨅvᄏԢଐ gՁy)ᨅ℣␤㌦ԩgAAmԐᄅଉጉᄉଔnPᄓ ༉gfԔᄈAgfԃvଈPAvጉԍଆᔐ༉ԔᄅgᄕPଆᄎgpnԈДnԘȍആଈmԆmng؃AvmnԏP܇gଉᄈPvnPؑy Jᔎrࠄl̕f̞xᄁrimeࠂЅ̙iᔅᔉy, (Ժ㨻ᴺ┥y GؘmԨᩁᨅℳ㔶㬦Ԫggଅ,ᄈAgଘ(ԨgጉᄉଔnPؑCՀᔆAȈPؑԔᄏԠȑ nPؑyԧgiՆ؋బ , v༉uP Ԣଉmmy GؘmԨᩁᨅvᄏԢ؊gAAԨy)ᨅℳ㔶┦ԿᄏȃnPؑԆ܅༉gfԔᄈAgଘԖᜅnଔᄘഒvᄈgs ഉଐؘngtuCԳᨅGଔ܈ԭPzgԔᄏԭДഉyl Jᔎrࠄl̕f̞xᄁrimeࠂЅ̤ᔕlᔉyᬃ (Ի┵ᴻ䈻y HȈ Аᄘؑԩ᨟ԢPA؈gԁᨅvᄏԨ.Dԭᨅ℣␤䈦ԜЉԔᤆA؈AԒPuᘬԛԎ؏gAԇ؋Ԗؑg ༉ᔉA؍ugpnCԋgጉᄉଔnPؑԔᄏԇଔ nȋgԄgvAPᄓyԫؑgԺ␬㨥h┷y KPgଏ؋RԞᨅvᄏՄPgଏ؋RՃᨅℳ㔵㘦Հ܇g nmԆ܅ଉnPᄆP Ԕ PsԆᄅഉ༐ AgԔᄏԇPଘnԔᄈAgf ጋ؊nЅPpԔԇvAA؊Ԗȃrԡ DИЃഄma AࠈЅs̕f̒ࠄtᔘy, (Ի䈻ᴻ䈥y KPgଏ؋RlEylvᄏl8vଈؘl:ylℳ㔵㔦lHଉvnugpnl؇lnЉlጋ.iPᄓlഉ༐ AgliPnalଉnPؑP lv Ps PᄃଉvmgslnЉlmPzgl؇lnЉlܐଘnlvᄈAgଘlPplܔAA؊l༉gflw DИa ഄma ☚l ComᄄrЂive Biᔓᴁmistrȳࠍ̐ᴚsiᔅᔉy̐Ќt̟ᬃ (䈝㔚l :PԩᨅvᄏԭȈnPgՁᨁᨅℳ㔵㨦԰PጄnԎP ଆm ؍P ԘnȏPgmԆ܅ഉ༐ AgԔᄏԉv଒ᜅܐଘnԔᄈAgf ༉ᔉA؍ugpnԐᄅଉsԏggଅw Cervฏ́lБᴎs Tᴁ̒ࠄtᔘicЅ̇ecᔌഛ (㌵㘝⌳┚ :PԩᨅvᄏԭȈnPgՁᨁᨅ℣␤㌦ԪggfԔᄈAgଆጉᄐ ԍgଐؘngȎ(ԔԍPg gԆ܅ആmnᄔnvAAD ଉnvPᄉsԉuᘋD.ᄐ ԈPmmȉ?ԛᄔn؎DԔᄏՀuᘋDؒؓDԣ␺(㭂┝㬶㘚 KଆᄉᄖȋጅHᨁᨅ℣␤㬦ԪgᔉA؍ugᄈvAԨgጂAvnPؑԆ܅nЉԓଆinaԍAvngyԧvnȋg 㨣㬬㬻⌝㬻㜚 :Pԩ᨟ՆvᄓԠ᨟԰PԹ᨟Թv؅X᨟ՉPᄓՉ᨟ԯgPՃ᨟ԪgᄓՉᨅvᄏԩAvଌԪᩀᨅ℣␤䈦 ,ᄈAgfԨgጉᄉଔnPؑ(ԛԪgഉᄏgᄈԢଆ gmmԆ܅)nguԜPmmȉԢଐugsՊPvԿᄈgଔ nPؑ 7PnaԐnmՀᄕgA؍Pᄓԭఐᄚl Jᔎrࠄl̕f̞xᄁrimeࠂЅ̤ᔕlᔉyᬃ ⤨⼁〇 e؂ᄈՁᨹ᨟ԁȲDAvrԁ᨟ԛAAgᄅ)᨟ԛAnБvPvpԜ᨟ԁ GؑᄉAAԔᄏԢଐ gՁy)ᨅ℣␤㜦 Eᔐ༉ᄃgԜДnԈЉԩvᄆᄐ vAԯᄈԭP጑vAAPᄓԢvnЊvᜅNgጂAvngmԪggଅ,ᄈAgf NgጉᄉଔnPؑyl DevelᔑmeࠂЅ̗yࠄmicsᬃ (Գ㬵␝㌻㔵y Jଐ gՁy)ᨅvᄏԛAAgᄅ)ᨅ℣␤㨦ՀᤍA؋PᄓԈЉԎg ДᄐmumԋgጂAvnPᄓԋgጉᄉଔnPؑԆR ༉gfԔᄈAgଘyl PᴊlᔏᔑᴊcЅ̥rЈsГtiᔈs̕f̂ᴁ̇ᔚЅ̦ᔓiety̙:̙iᔅᔉicЅ̦cieࠓes, (㘤㔝㘣⌚ Jଐ gՁy)᨟ԛAAgpԭ᨟ԠvȃЉșԩ᨟ԛAnБvPvpԜyԔᄏԁ؂ᄈՁyGᨅ℣␤┦ԪggଅvᄈAgଘ(Ԕ z؆AؓP vAԃȋPؘPnᜅ؋ԈЉԌgᜅn؅ȑ༉ଘnvᄏPᄓԆଓvᄅଉጉᄉଔnPؑԐᄅuvuuvAm? Jᔎrࠄl̕f̒ࠄtᔘyᬃ (Է␻ᴷ㌶y JȈuvpԨᨅℳ㔶㘦l Tᴁ̨ЂฌЅ̜istᔌy̕f̗eer 3ЋPmn؍ЉfՃgAuԡg༚☟԰ؑ༆ᄚ ) v༏Pᄓԭᨨᨅvᄏԁv༉ᄅeᨅℳ㔵㨦ԨgnPᄆP Ԕ Psԓଔ༐gᄈmԏȋPᄓԒPuI ଉጉᄉଔnPؑyl DevelᔑmeࠂЅ̙iᔅᔉy, (Է␶ᴷ㍂y )ȈnPgՁᨁ᨟ԹAȃఎvpԢᨪ᨟ԫȈAgfՁᩃ᨟ԠgᄑgmmᜅJᨠ᨟ԩ؋mؑԿᨪᨅvᄏ԰vvmԠᩁy ℳ㔶┦ԿᄘȒPᄝAPఉԓଆinaԇv n؋Գԡ㼹Vᴳ★vᄈAgfԘnPuȒvnPᄓԄ؋uؑg? Eࠍᔓriࠕlᔉy, (Զ㨷ᴶ㨶 eI rਆܡ.icdal 4vᄐgAԐmԣ㌅DgvଘԆAsԔᄏԖgጔᄅmnȏDPᄓԐᄅnЉԭ ІؒԆ܅8Pؘ Pgᄃgmԅv܈gf ؎dAgnPᄓԄPmԛᴰgᔉAmCԓଔ༂vnPᄓԐᄅ⌤⑂ԊPnЅvԣ(㌅8) ԡHؑm★PpԛᄐuvA ) PgᄃgyԛmԍvଈԆ܅АmԏPmmgଈvnPؑCԪvᄐgAԔnngᄏgsԈЉԘPᤈaԿᄈg଑vnPؑvAԪggf 8Pؒؓᜅ3ؑጋgmmԐᄅJଔጂgἅnІଆȓВᜅgpj.DPᄓԈЉԃДᄃgԈ.ԔnngᄏԘȃaԔᄅgᔉᄈC ܐᄏPᄓԈЉԊІAgԉᤍgଐgᄃgԐᄕvAȔᘒgyԯАAmnԘnȏDPᄓԔnԈЉԭ ІؒԆR 8Pؘ PgᄃgmCԪvᄐgAԊvmԍvଈP Ȓv଒DԐᄈgଉmngsԐpԈЉԍІn؍gଐ؏P ԃؑnଆAԆ܅nЉ gᄏ؃ଐᄉԘDmnguyԪvᄐgAԊPAAԖgጐpԈ؅mnȏDԇ؋ԔԏgጋggԐᄅugsP PpgԐᄅ⌤⑂Ԕᄏ ІഉmԈ.ԉpj.DԔԃvଉgfԃ؎IPᄐᄓԖ؈ЅଉmgvଃaԔᄏԍvnPgᄈԃؑnv ny