Qing Pan Adla Angelina Michael Marrone Walter J Stark Esen K Apek Issue 2 2017 A presentation to Meeting name Date Table of Contents 01 Background 02 Types of studies 03 Key results ID: 920661
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Slide1
Autologous serum eye drops for dry eye Qing Pan, Adla Angelina, Michael Marrone, Walter J Stark, Esen K ApekIssue 2, 2017
A presentation to:
Meeting name
Date
Slide2Table of Contents01
Background
02
Types
of studies
03
Key results
04
Tables (Risk of Bias/Forest Plots)
05
Conclusions
06
Acknowledgements
Slide301: BackgroundDry eye is a common disorder, often treated with artificial tearsArtificial tears lack biological nutrients found in natural tears
Autologous serum eye drops are made by separating liquid and cellular components of the patients blood
Question is:
Are autologous serum drops a safe and effective alternative to artificial tears?
Slide402: Types of studiesParticipantsFive randomized controlled trials (RCTs) with 92 participants (149 eyes) with dry eye caused by various conditionsInterventionsAutologous serum drops, alone or in conjunction with artificial tears
VERSUS
Artificial tears, saline, placebo, or no treatment
Slide503: Key results“…the mean OSDI score in the AS 20% group was lower than in the artificial tears group, although scores for both groups fell within the moderate OSDI category.”Assessed at four weeks
“…
the mean composite symptom score was 5.36 for the 20% AS group and 6.45 for the saline
group. Trial investigators reported that mean symptom scores were not statistically significantly different.”
Slide603: Key results (continued)Mean differences in fluorescein and Rose Bengal staining before and after treatment were not clinically important and were still classified as abnormal. Tear film break-up time also saw no clinically important differences between treatment groups. Results from
Schirmer’s
test were also considered clinically unimportant.
Slide704: Tables
Slide805: Conclusions“The five trials comparing AS versus artificial tears or saline did not consistently observe improvement in participant-reported symptoms.”
“A
major difficulty that review authors encountered in summarizing the results of included studies was heterogeneity among participant populations, interventions, and comparisons
,
as well as variation in procedures performed to prepare AS
.”
Slide906: AcknowledgementsCochrane Eyes and Vision US Satellite, funded by the National Eye Institute, National Institutes of HealthCochrane Eyes and Vision Editorial Base, funded by the UK National Health Service Research and Development
Programme
Qing Pan, Adla Angelina, Michael Marrone, Walter J Stark, Esen K Akpek
Review citation
Pan Q, Angelina A,
Marrone
M, Stark WJ,
Akpek
EK. Autologous serum eye drops for dry eye. Cochrane Database of Systematic Reviews 2017, Issue 2. Art. No.: CD009327. DOI:
10.1002/14651858.CD009327.pub3