PPT-Web of Causality: Sepsis Mortality in Philadelphia

Melissa Lester Dr Matt Wray Department of Sociology Temple University Philadelphia PA What is Sepsis Bacteria or fungus enter bloodstream 2 Community or hospital acquired 3 Response by innate immune system to infections. ACTG Network Meeting. June 20, 2011. Ling Chin, MD, MPH. Safety Pharmacovigilance Team Leader, DAIDS. Deborah McMahon. , MD. University of Pittsburgh. ACTG - PEC. Olu Og. unyankin. , MD. DAIDS RSC . Safety & Pharmacovigilance Specialist. Responsibility. f. or Query Answers and non-Answers. Alexandra Meliou, Wolfgang . Gatterbauer. , . Katherine . Moore, . and . Dan . Suciu. http://db.cs.washington.edu/causality/. 1. Motivating . E. xample: Explanations. `. Christa A. Schorr RN, MSN, FCCM. Assistant Professor of Medicine. Cooper Medical School of Rowan University. Director of Databases for Quality Improvement and Research. Program Director of Critical Care Clinical Trials . Adult Inpatients. Learning objectives. Recognise that sepsis . i. s a medical emergency. Identify the risk factors, signs and symptoms. Outline the escalation of the septic patient . Define the . initial management actions. program . (general overview). add . LHD and/or hospital name. Aims. Provide an overview of the SEPSIS KILLS program . and its impact in this LHD/facility. Outline the elements of the inpatient SEPSIS KILLS program. Papers to cover. Nguyen. Early lactate clearance is associated with improved outcome in severe sepsis and septic shock . P. Single centre prospective observational study of patients with septic shock. Dr. Vida Hamilton. National Clinical Lead Sepsis. www.hse.ie/sepsis. Sepsis - 2. A dysregulated immune response to infection. Regulated. Innate & Adaptive. Cellular: Dendritic cells, T-cells, B-cells. Stage 1. Source: world-sepsis-day.org . What is Sepsis?. Source: world-sepsis-day.org . Sepsis at a Glance. Sepsis is a . medical emergency . . . . . Source: . Advisory Board Company: “Why sepsis screening isn't one-size-fits-all” . Early Goal Directed Therapy. and Beyond. Anthony J. Hericks, D.O.. South Dakota. ACP. Scientific Meeting. September 13. th. , . 2013. A clinician, armed with the sepsis bundles, attacks the three heads of severe sepsis: hypotension, hypoperfusion and organ dysfunction. . Objectives. “Sepsis is caused when the body’s . immune system becomes overactive in response to an infection. , causing inflammation which can affect how well other tissues and organs work.”. –National Institute for Health and Care Excellence Guidelines. Early recognition of Sepsis. Early Goal Directed Therapy . CASE. 6. 4yr . Samoan male. 24 . hr. . Fever, productive cough, SOB . and . delirium. Initial . Obs. HR 162, RR . 40, . sats. . 90% . on 15l, BP . CASE STUDY. A 53-year old woman presents complaining of several days of fever, generalized malaise, nausea & vomiting. She has a PMH of diabetes and HTN and takes . Glucophage. and . Lisinopril. National Clinical Lead Sepsis. www.hse.ie/sepsis. Sepsis. ‘Final . common pathway for death from . infection’. National Awareness Survey 2016. 25% Doctors . & . 29% Nurses interviewed. . . Sepsis,. . TNF-α. . Association. . with. . Mortality. . but. . not. . Sepsis. . Severity. . or. . Infection. . Source:. . a. . Systematic. . Review. and. . Meta-analysis. Amal. . A..