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Clinical Research  Data & System Strategy Session Clinical Research  Data & System Strategy Session

Clinical Research Data & System Strategy Session - PowerPoint Presentation

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Uploaded On 2018-03-14

Clinical Research Data & System Strategy Session - PPT Presentation

Michael Kamerick Sr Director of Health Systems Solutions Recombinant Systems Diana Gumas Director of Clinical and Clinical Research IT 1 Goals for Todays Session 2 ID: 650871

data clinical i2b2 research clinical data research i2b2 amp registry enterprise systems discovery cohort find phenotype state today

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Slide1

Clinical Research Data & System Strategy Session

Michael Kamerick, Sr. Director of Health Systems Solutions, Recombinant SystemsDiana Gumas, Director of Clinical and Clinical Research IT

1Slide2

Goals for Today’s Session

2

Understand our current state with regards to clinical research enterprise systems

Learn what other institutions have done to leverage their clinical research enterprise systems

Develop a strategy for clinical research enterprise system data contents and interfacesSlide3

Current State

3Slide4

What are others doing?

UMass – cohort discovery + finding samples in biobank based on clinical phenotypeCity of Hope – integrate i2b2 with tissue repository

Cincinnati Children’s – Liver transplant registry, cohort discovery

Thomas Jefferson – i2b2 linked with tumor registry &

biospecimen

repositoryHarvard / Mass General – use i2b2 for EHR driven genomic research in numerous disease categoriesHarvard/Partners - rheumatoid arthritis phenotypes using diagnosis codes & NLP of documents

Insights from Michael Kamerick…

4Slide5

High Level Points from Today’s Discussion

Establish a “Data Trust” and associate governance, to be led by Dr. Peter Greene with help from RecombinantLimit data in caTissue

to specimen metadata and limited clinical annotation. TBD as to what limits are reasonable

To make #2 work, need to be able to spin off as needed protocol-specific data marts for clinical data that researchers are entitled to.

Need for permissions registry

Use of i2b2 to find tissues associated with a clinical phenotype

(FUTURE) Use of i2b2 to find genotype associated with clinical phenotype

Data repository should be in FISMA-controlled environment

Labeling data as research data if in the clinical record

Need to more easily access image data from multiple sources

5