cADPribose amp Inositol lipid signaling BIOL 51906190 Cellular amp Molecular Singal Transduction Prepared by Bob Locy Last modified 13F CSB Fig 0201 Cell signalling pathways ID: 402227
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Slide1
Lecture 09 – Second Messengers III – cADPribose & Inositol lipid signaling
BIOL 5190/6190 Cellular & Molecular
Singal
Transduction
Prepared by Bob Locy
Last modified -13FSlide2
CSB Fig 02:01 Cell
signalling
pathways
Cell
Signalling
Biology - Michael J.
Berridge
- www.cellsignallingbiology.org - 2012 Slide3
Transducers Second Messengers IICyclic ADPribose
ADP
Ribosyl
cyclaseInositol phosphate & other lipid signaling
PLC – PIP2, DAG
PI3K – PIP3
PLD – PASlide4
Cell Signalling
Biology - Michael J.
Berridge
- www.cellsignallingbiology.org - 2012
CSB Fig 2:22
cADPR
metabolism Slide5
Cell Signalling
Biology - Michael J.
Berridge
- www.cellsignallingbiology.org - 2012
CSB Fig 2:26 NAADP structure Slide6
Cell Signalling
Biology - Michael J.
Berridge
- www.cellsignallingbiology.org - 2012
CSB Fig 2:23
cADPR
/NAADP function Slide7
Transducers Second Messengers IICalcium signaling
Cyclic
ADPribose
Inositol phosphate & other lipid signalingPLC – PIP2, DAG
PI3K – PIP3
PLD – PASlide8
Cell Signalling
Biology - Michael J.
Berridge
- www.cellsignallingbiology.org - 2012
CSB Fig 2:30
Phosphoinositide
signalling
systems Slide9
Cell Signalling
Biology - Michael J.
Berridge
- www.cellsignallingbiology.org - 2012
CSB Fig 2:27
Phosphoinositide
metabolism Slide10
Cell Signalling
Biology - Michael J.
Berridge
- www.cellsignallingbiology.org - 2012
CSB Fig 2:28
PtdIns
structure Slide11
Cell Signalling
Biology - Michael J.
Berridge
- www.cellsignallingbiology.org - 2012
CSB Fig 2:29 PI 3-K family Slide12
Cell Signalling
Biology - Michael J.
Berridge
- www.cellsignallingbiology.org - 2012
CSB Fig 2:31 Inositol phosphate metabolism Slide13
Cell Signalling
Biology - Michael J.
Berridge
- www.cellsignallingbiology.org - 2012
CSB Fig 2:32 InsP3 and DAG formation Slide14
Cell Signalling
Biology - Michael J.
Berridge
- www.cellsignallingbiology.org - 2012
CSB Fig 2:33 InsP3 and DAG formation Slide15
Cell Signalling
Biology - Michael J.
Berridge
- www.cellsignallingbiology.org - 2012
CSB Fig 2:34 InsP3/Ca2+
signalling
functions Slide16
Cell Signalling
Biology - Michael J.
Berridge
- www.cellsignallingbiology.org - 2012
CSB Fig 2:35 InsP3/DAG recycling Slide17
Cell Signalling
Biology - Michael J.
Berridge
- www.cellsignallingbiology.org - 2012
CSB Fig 2:36 PLC structure and function Slide18
Cell Signalling
Biology - Michael J.
Berridge
- www.cellsignallingbiology.org - 2012
CSB Fig 2:37 PKC structure and activation Slide19
Cell Signalling
Biology - Michael J.
Berridge
- www.cellsignallingbiology.org - 2012
CSB Fig 2:38 Localized inositol lipid
signalling
Slide20
Cell Signalling
Biology - Michael J.
Berridge
- www.cellsignallingbiology.org - 2012
CSB Fig 2:39 PtdIns4,5P2
signalling
Slide21
Cell Signalling
Biology - Michael J.
Berridge
- www.cellsignallingbiology.org - 2012
CSB Fig 2:40 PtdIns4,5P2 regulation of K+ channels Slide22
Cell Signalling
Biology - Michael J.
Berridge
- www.cellsignallingbiology.org - 2012
CSB Fig 2:41 PtdIns4,5P2 regulation of TRP channels Slide23
Cell Signalling
Biology - Michael J.
Berridge
- www.cellsignallingbiology.org - 2012
CSB Fig 2:42
PtdIns
3-kinase
signalling
Slide24
Cell Signalling
Biology - Michael J.
Berridge
- www.cellsignallingbiology.org - 2012
CSB Fig 2:43 Insulin receptor Slide25
Cell Signalling
Biology - Michael J.
Berridge
- www.cellsignallingbiology.org - 2012
CSB Fig 2:44
PIKfyve
activation