Addendum 1 to The use of stems in the selection of International Nonproprietary Names for Pharmaceutical Substances WHOEMPQSM20093 23axo presubstem ratmouse hamster primate human chimeric discu ID: 863297
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1 INN Working Document 09.260 03/12/2009 A
INN Working Document 09.260 03/12/2009 AddendumWHO/EMP/QSM/2009.3Programme on International Nonproprietary Names (INN) Quality Assurance and Safety: Medicines (QSM)World Health Organization, Geneva© World Health Organization 2009 - All rights reserved. The contents of this document may not be reviewed, abstracted, quoted, referenced, reproduced, transmitted, distributed, translated or adapted, in part or in whole, in any form or by any means, without explicit prior authorization of the WHO INN Programme. This documen
2 t contains the collective views of the I
t contains the collective views of the INN Expert Group and does not necessarily represent the decisions or the stated policy of the World Health Organization. Addendum 1 to "The use of stems in the selection of International Nonproprietary Names for Pharmaceutical Substances" WHO/EMP/QSM/2009.3 2/3 axo (pre-sub-stem) rat/mouse hamster primate human chimeric discussion) chimeric/humanized humanized The distinction between chimeric and humanized antibodies is as follows: A chimeric antibody is one that contains c
3 ontiguous foreign-derived amino acids co
ontiguous foreign-derived amino acids comprising the entire variable domain of both heavy and light chains linked to heavy and light constant regions of human origin. A humanized antibody has segments of foreign-derived amino acids interspersed among variable domain segments of human-derived amino acid residues and the humanized variable heavy and variable light domains are linked to heavy and light constant regions of human origin. The - infix is used for an antibody having both chimeric and humanized chains. The infi
4 x is used for an antibody having both ra
x is used for an antibody having both rat and mouse chains. Substem A indicates the target (molecule, cell, organ) class: -b(a)- bacterial -c(i)- cardiovascular -f(u)- fungal -k(i)- interleukin -l(i)- immunomodulating -n(e)- (under discussion) neural -s(o)- -tox(a) t(u) tumour -v(i)- viral In principle, a single letter, e.g. for bacterial is used as substem A. Whenever substem B starts with a consonant (e.g. x or z), to avoid problems in pronunciation, an additional vowel indicated in the table, e.g. is insert