PPT-Mechanisms of acute toxicity and using

ToxCast data to predict acute toxicity Dan Wilson PhD DABT Science Leader Cheminformatics The Dow Chemical Company ddwilsondowcom 9896360712 EPAs Computational Toxicology Communities of Practice. GHS. and older . labelling . and classification systems in Australia. The . G. lobally . H. armonized . S. ystem of Classification and Labelling of Chemicals. This presentation is released under the . Cyclodienes. Aldrin and dieldrin, endrin and isodrin. Chlordane and heptachlor. Mirex and chlordecone. Lindane. Endosulfan. Hexachlorobenzene and pentachlorophenol. Toxaphene. Cyclodiene Insecticides. Chapter 5: 1. Acute toxicity refers to those adverse effects occurring following oral or dermal administration of a single dose of a substance, or multiple doses given within 24 hours, or an inhalati Shock. Emergent Disorders in Critical Care . Shock. Decreased tissue perfusion . . inadequate O2 delivery . . . tiessue. ischemia. Common Clinical Features of Shock. 1. HYPOTENSION. SBP < 90 mm Hg. Dr. Naila Abrar. LEARNING OBJECTIVES. By the end of this session you should be able . to: . define . drug . toxicity;. know . the types of . toxicity;. comprehend . the reasons that may lead to toxicity of . . Explosive. Organic Peroxide. Flammable. Pyrophoric. Self-Heating. Oxidizer. Gas under Pressure. . Corrosive. Acute Toxicity. Carcinogen. Respiratory Sensitizer. Reproductive Toxin. Environmental Hazard. A Review of the Basic Science. 1. Prevalence of Hyperglycemia in Critically Ill Patients. 2. CIAH, critical illness associated hyperglycemia.. Plummer MP, et al. . Intensive Care Med. . 2014;40:973-980.. Technical Fact Sheet Update to Reflect BPPD Change of Address Date Issued October 1998 On This Page Description of the ChemicalUse Sites Application Timing Target PestsFood Clearances / TolerancesSc Page 1 of 4 reflecting the US OSHA Implementation of Globally Harmonized System GHS of Produced by the SCHC-OSHA Alliance /HazCom Information Sheet Workgroupby inhalationis defined as solid particles Shock. Decreased tissue perfusion . . inadequate O2 delivery . . . tiessue. ischemia. Common Clinical Features of Shock. 1. HYPOTENSION. SBP < 90 mm Hg. MAP <60 mm Hg. Acute decreased in SBP of > 40 mm Hg. Gabriele Ludewig, PhD. University of Iowa. PCBs in Schools. Risk e-Learning . Webinar . April 28, 2014. Outline. Human diseases and PCBs . Receptor-driven mechanisms. AhR. RYR. ER. Metabolic activation. Now, we can talk about its toxicity . The therapeutic, and many of the . toxic . effects of the NSAIDs result from . inhibition . of the enzymes in the cyclooxygenase (COX) group. This results in a decrease in the synthesis of prostaglandins and thromboxane A2, from the precursor . Review of Literature. Sumeet Prakash Mirgh, Jehangir Soli Sorabjee. Isoniazid (INH) is a crucial drug in the prevention and treatment of tuberculosis. INH is commonly known to cause derangements in liver function tests and peripheral neuropathy due to pyridoxine deficiency in slow acetylators. However, in toxic doses it is known to cause severe neurologic manifestations and acute metabolic acidosis. INH toxicity is characterized by the clinical triad of repetitive seizures unresponsive to the usual anticonvulsants, metabolic acidosis with a high anion gap and coma. Hence, the diagnosis of INH overdose should be considered in any patient who presents to Emergency medical services (EMS) with the triad. Though accidental overdose of anti-tuberculosis drugs have been reported in children and adults, acute toxicity is rare. When recognized, intravenous pyridoxine and correction of acidosis with sodium bicarbonate and supportive treatment is effective. The condition is easily treated with intravenous pyridoxine but if not treated in time could prove fatal. Unlike other poisonings, serum INH levels do not co-relate with either symptomatology or liver injury.. B.Pharm. . Sixth Sem.. BP602T. Subacute Toxicity. Subacute toxicity studies are intended to evaluate a drug's toxic potential and pathological effects following a treatment/. repeated administration.