IDOXURIDINE trifloride GANCICLOVIR 1 DIDANOSINE DDI Nomenclature 95 hydroxy methyltetrahydrofuran2yl 3Hpurin69Hone Didanosine is a purine 23dideoxyribonucleoside that is inosine in which the hydroxy groups at both the 2 and the 3 ID: 1033679
Download Presentation The PPT/PDF document "Anti viral Drugs 2 DIDANOSINE" is the property of its rightful owner. Permission is granted to download and print the materials on this web site for personal, non-commercial use only, and to display it on your personal computer provided you do not modify the materials and that you retain all copyright notices contained in the materials. By downloading content from our website, you accept the terms of this agreement.
1. Anti viral Drugs 2DIDANOSINEIDOXURIDINE triflorideGANCICLOVIR .
2. 1. DIDANOSINE (DDI)Nomenclature:9-(5-(hydroxy methyl)tetrahydrofuran-2-yl)-3H-purin-6(9H)-oneDidanosine is a purine 2',3'-dideoxyribonucleoside that is inosine in which the hydroxy groups at both the 2' and the 3' positions on the sugar moiety have been replaced by hydrogen. An antiviral drug, it is used as a medication to treat HIV/AIDS.MOA: ddI is phosphorylated to the active metabolite of di-deoxy-adenosine triphosphate, ddATP, by cellular enzymes. Like other anti-HIV nucleoside analogs, it acts as a chain terminator by incorporation and inhibits viral reverse transcriptase by competing with natural dATP.
3. 2. IDOXURIDINE trifloride IUPAC name. 1-[4-hydroxy-5-(hydroxy methyl)oxolan-2-yl]-5-iodo-1,2,3,4-tetrahydropyrimidine-2,4-dioneMOA: by inhibiting viral replication by substituting itself for thymidine in viral DNA. This in turn inhibits thymidylate phosphorylase and viral DNA polymerases
4. 3. Ganciclovir (CYTOVENE-IV)IUPAC: 2-Amino-9-(1,3-dihydroxypropan-2-yloxymethyl)-3H-purin-6-one Ganciclovir is an oxopurine that is guanine substituted by a [(1,3-dihydroxypropan-2-yl)oxy]methyl group at position 9. Ganciclovir is an antiviral drug used to treat or prevent AIDS-related cytomegalovirus infections. It has a role as an antiviral drug and an antiinfective agent.