PPT-Genome Rearrangements

Basic Biology DNA Genetic information is stored in deoxyribonucleic acid DNA molecules A single DNA molecule is a sequence of nucleotides adenine A cytosine C guanine G. 9-3. Hydride shifts give new S. N. 1 products.. Treatment of substituted secondary alcohols produces unexpected results:. Rearrangement of an initial secondary carbocation to the more stable tertiary carbocation by a hydride shift results in a rearranged product.. 2. Some genomics history. 1995: first bacterial genome, . Haemophilus influenza. , 1.8 Mbp, sequenced at TIGR. first use of whole-genome shotgun for a bacterium. Fleischmann et al. 1995 became most-cited paper of the year (>3000 citations). from Biological . Problem to . Combinatorial Algorithms. (and back). Pavel Pevzner. Department of Computer . Science,. . University . of California at San Diego. What is the evolutionary scenario for transforming one genome into the other?. Timetable for today. Time. Activity. 00:00. Introduction to the session. 00:10. Story cards . 00:20. Info cards. 00:30. Issue cards. 00:40. Discuss two key. issues. 00:45. Feedback your issues. What is DNA?. Genome: the total number of genes in an individual.. Human Genome- approx. 20,000 genes on the 46 human chromosomes.. Human Genome Project (HGP). Ongoing effort to completely map and sequence our genome.. Key considerations:. Genes . Chromosomes. C value paradox. Gene regulation. Epigenetics. Transposable elements. DNA . ……..……..mRNA……….…….Protein . Plant . Estimated # genes. Arabidposis. Key considerations:. Genes . Chromosomes. C value paradox. Gene regulation. Epigenetics. Transposable elements. DNA . ……..……..mRNA……….…….Protein . Plant . Estimated # genes. Arabidposis. equestors should include the following items in their Research Use Statements A statement explaining why the HeLa genome sequence data are of value to the proposed research (i.e., why these data are Evolution occurs through a set of modifications to the DNA. These modifications include point mutations, insertions, deletions, and rearrangements. Seemingly diverse species (say mice and humans) share significant similarity (80-90%) in their genes. , Seda Klç , Demet Akdeniz , Özge ükrüolu , eref Bura Tuncer , Mukaddes Avar Gözde Kuru , Betül Çelik , Seden Küçücük , Pnar Saip Department of Cance signicance dicult to ascertain []. ere are numerous other common cytogenetic ndings that are not routinely used for risk stratication, including 11q23 rearrangements, despite their prevalence in G-OnRamp Beta Users Workshop. Wilson Leung. 07/2016. Outline. Obtain genome assemblies from NCBI. Transfer . large genomics datasets to Galaxy. Common bioinformatics file formats . D. atatypes in Galaxy. CSE291: Personal Genomics for . Bioinformaticians. 01/. 10/17. The personal genomics revolution. 23andMe. : >1 million customers . (. $200). Genographic. Project: . >800,000 customers ($150). Family Tree DNA: . emm1. invasive Group A . Streptococcus. isolated from Belgian patients during 1994˗2013 . J. Coppens. 1. , . B. B. . Xavier,. . J. Sabirova. 1. , C. Lammens. 1. , K. Loens. 2. , S. Malhotra-Kumar.