Adapted from Stacy Neurol Clin 200927605631 Chapuis et al Mov Disord 2005202224230 1 Wearingoff delayed ON 8 am levodopa dose Clinical response 2 am Wearingoff ID: 1033885
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1. Parkinson’s diseaseRelationship between levodopa administration and motor fluctuationsAdapted from: Stacy. Neurol Clin 2009;27:605–631; Chapuis et al. Mov Disord 2005;20(2):224–2301Wearing-off/delayed ON8 a.m.levodopa doseClinical response2 a.m.Wearing-off/delayed ON2 p.m.levodopa dose8 p.m.levodopa doseTime8 a.m.levodopa doseBlood concentration of levodopaNocturnal akinesiaEarly morningakinesiaRisk of dyskinesiaGood symptom controlRisk of akinesia