PPT-Biomarker Analyses in CLEOPATRA: A Phase III

PlaceboControlled Study of Pertuzumab in HER2 Positive FirstLine Metastatic Breast Cancer MBC Baselga J et al Proc SABCS 2012 Abstract S51 Background The Phase III CLEOPATRA study reported that . 2600 BCE – 31 BCE. Egypt in Decline. Revolts happen in Nubia, Palestine, Israel which push the Egyptians back to their traditional land near the Nile. Low floods hurt crops and trade. Egyptian army dependent on mercenaries yet poor trade means that there is not always enough money to pay them.. Bl. 7. February 26. th. 2009. A Life Worth Knowing. The Beginning of Cleopatra’s Life. Cleopatra was born 69 B.C.. One of the most famous Egyptian rulers for over three hundred years. Was a threat to the throne, her father made her marry her brother, and they both ruled the throne. Practices & Experiences. Shawn Li, M.D., Ph.D.. October 1, 2012. Introduction. Frontage Capabilities and Approaches. Case Studies. Challenges and Solutions:. Measurement of . Analyte. in Presence of Endogenous Protein. Queen of Kings. The Baby is here!. In 69 BC Cleopatra was born in Alexandria, Egypt. Her mother is unknown and her father is Ptolemy Xll . Teenage Queen. At age eighteen Cleopatra became queen. She also married her younger brother Ptolemy . Cleopatra VII.  . g. ; 69. . – August 12, 30 BC), known to history simply as . Cleopatra. , was the last active pharaoh of Ancient Egypt, only shortly survived by her son, . Caesarion.  as pharaoh.. Christopher . Jennison. , University of Bath. Robert A. Beckman, Daiichi Sankyo Pharmaceutical Development and University of California at San Francisco. Agenda. TOPIC 1: Where do subgroups come from? Empirical data or basic science? How does this vary as a function of developmental stage? . By: Kein Geld, Alfonso Uno Shorebut, Shang Tang Quilo, José Booshkai, and BOB :).. Cleopatra. Cleopatra was the daughter of Auletes. Her mother, believed to be Cleopatra V, was the kings wife/half sister. In 51 B.C, her mother died and the throne was passed on to her and her brother while she was still 18. Her brother, who was named Ptolemy XIII, was 10. Soon after they took the throne, Ptolemy's advisers acted against Cleopatra and forced her to leave Egypt for Syria in 49 B.C. She created an army and fought her brother on the eastern border of Egypt. Meanwhile, both the brother and the sister were asking Ceasar's help in the fight.. LINES 1 - 78. By, Ezra and Sarah . Summary. At Cleopatra’s palace in Alexandria, . Enobarbus. . consoles . Cleopatra, claiming . Cleopatra has no fault in his defeat—Antony chose to let his affection for her overpower his reason, so Antony bears both the shame and the loss. This is cold comfort to Cleopatra.. BCE. led . to . thirteen . years of war and ultimately . to . the end of the Roman Republic. . By . 33. BCE. , both Caesar’s . most . trusted . lieutenant . and the last queen of Egypt . would . be dead, and a young man . -. . . Ruined Masculinity . - . or. -. . . . Scenes from a life as tragedy?. Romeo. :. O, sweet Juliet!. Thy beauty hath made me effeminate,. And in my temper . soften’d. valour’s steel! (3.1.121). Cleopatra WORLD HISTORY READERS Level 3- ③ Cleopatra and Egypt Who was Cleopatra? Cleopatra was the queen of a country called Egypt in North Africa who lived over 2,000 years ago. What is Egypt John Michael Sauer, PhD. Critical Path Institute’s Predictive Safety Testing Consortium. Tucson, Arizona. jsauer@c-path.org. So you have a biomarker(s) that you want to use for regulatory decision making…now what do you do?. PhUSE 2014 Paper SP06 Renuka Chinthapally, Cytel Statistical Software & Services Pvt. Ltd., Hyderabad, India ABSTRACT Biomarkers play an important role in the clinical development due to their ability What do you already know about Cleopatra?. List 5 things you know about Cleopatra.. Visual Sources. Look at the following Images. What impression do they give of Cleopatra?. Think up . Adjectives. to describe each image..