Pagets disease ( osteitis

 Pagets  disease ( osteitis  Pagets  disease ( osteitis - Start

2020-04-10 2K 2 0 0

Pagets disease ( osteitis - Description

. deformans. ). Definition . - idiopathic Skeletal bone disorder in which there is excessive bone . resorption. followed by replacement of altered bone . tissue. The new bone is larger, disorganized and structurally . ID: 776601 Download Presentation

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Pagets disease ( osteitis




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Presentations text content in Pagets disease ( osteitis

Slide1

Pagets

disease (

osteitis

deformans

)

Slide2

Definition

- idiopathic Skeletal bone disorder in which there is excessive bone

resorption

followed by replacement of altered bone

tissue

The new bone is larger, disorganized and structurally

weaker

Common

sites–

pelvis , long bones, spine, ribs, sternum and cranium

Slide3

Exact cause is unknownFollowed by viral infection (measles virus, respiratory syncytial virus )Genetic (15%-30%)Men to women ratio – 2:1 Seen in below 40 years

Etiology

Slide4

Due to unknown causes Increase BONE RESORPTION Altered BONE TURN OVERAs a compensatory mechanism - increase bone formation Newly formed bones are large, unorganized and weakStructural changes in weight bearing limbs and other manifestation

Pathophysiology

Slide5

Free of symptoms in the early stagesBone pain – deep ache – progress to severe painFatigue Progressive development of waddling gaitBecome shorterBarrel chest

Signs and symptoms

Slide6

Bowing of tibia or femurChanges in skin temperature Manifestations related to nerve compression

Slide7

Increase bone volume in the spine can cause spinal cord or cranial root compression leads to head ache, blindness, vertigo, hearing loss with tinnitus and dementia

Pathologic fracture ,

osteosarcoma

,

fibrosacroma

and

osteoclastoma

tumors are complications

Osteoarthritis are common associated with

pagets

disease

Slide8

X rays – shows increased bone expansion and density.Bone scanSerum alkaline phosphates levels increasedN-telopeptide and C-telopeptide they are biomarkers used to measure the rate of bone turnover, can be measure from urine or serum

Diagnostic investigation

Slide9

Limited to symptomsSupportive careCorrection of secondary deformity Calcitonin – decrease osteoclastic activity

Management


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