deformans Definition idiopathic Skeletal bone disorder in which there is excessive bone resorption followed by replacement of altered bone tissue The new bone is larger disorganized and structurally ID: 776601
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Slide1
Pagets
disease (
osteitis
deformans
)
Slide2Definition
- idiopathic Skeletal bone disorder in which there is excessive bone
resorption
followed by replacement of altered bone
tissue
The new bone is larger, disorganized and structurally
weaker
Common
sites–
pelvis , long bones, spine, ribs, sternum and cranium
Slide3Exact cause is unknownFollowed by viral infection (measles virus, respiratory syncytial virus )Genetic (15%-30%)Men to women ratio – 2:1 Seen in below 40 years
Etiology
Slide4Due to unknown causes Increase BONE RESORPTION Altered BONE TURN OVERAs a compensatory mechanism - increase bone formation Newly formed bones are large, unorganized and weakStructural changes in weight bearing limbs and other manifestation
Pathophysiology
Slide5Free of symptoms in the early stagesBone pain – deep ache – progress to severe painFatigue Progressive development of waddling gaitBecome shorterBarrel chest
Signs and symptoms
Slide6Bowing of tibia or femurChanges in skin temperature Manifestations related to nerve compression
Slide7Increase bone volume in the spine can cause spinal cord or cranial root compression leads to head ache, blindness, vertigo, hearing loss with tinnitus and dementia
Pathologic fracture ,
osteosarcoma
,
fibrosacroma
and
osteoclastoma
tumors are complications
Osteoarthritis are common associated with
pagets
disease
Slide8X rays – shows increased bone expansion and density.Bone scanSerum alkaline phosphates levels increasedN-telopeptide and C-telopeptide they are biomarkers used to measure the rate of bone turnover, can be measure from urine or serum
Diagnostic investigation
Slide9Limited to symptomsSupportive careCorrection of secondary deformity Calcitonin – decrease osteoclastic activity
Management