PPT-Basics of the parametric frailty model

Luc Duchateau Ghent University Belgium Overview Frailty distributions The parametric gamma frailty model The parametric positive stable frailty model The parametric lognormal frailty model Frailty distributions. workshop. Luc Duchateau. Ghent University, Belgium. Event times in clusters of varying size. Many large clusters (1). One level of clustering, but varying cluster size. Example: Time to culling of heifer cows as a function of early somatic cell count. Latana A. Munang. Consultant Physician and Geriatrician. St John’s Hospital. Outline. The status quo. Frailty. Comprehensive Geriatric Assessment. The Frailty Pathway. Summary & Discussion. Projected population change West Lothian. Clin. J Am . Soc. . Neprol. . 2013 . Jul;8(8):. 1421-8. Swindler M.. Jenni. . Harrison . CT2. August 2013. . Overview. Frailty…….& Me. The paper – technical aspects & background. 3 issues to discuss:. semiparametric. frailty model. Luc Duchateau. Ghent University, Belgium. Fitting the . semiparametric. . frailty. model. The EM approach. The . penalised. . partial. . likelihood. approach. The . Functional Max-Margin Markov Networks. Dan. Munoz. Drew Bagnell. Nicolas . Vandapel. Martial Hebert. Problem. Wall. Vegetation. Ground. Tree trunk. Sky. Support. Vertical. Geometry Estimation. (. Hoiem. 2 Bank of Canada WorkingPaperSeptemberWhich Parametric Model for ConditionalSkewnessBruno Feunou,Mohammad R. JahanParvarand Rom Volkan. Cevher. Laboratory. for Information and Inference Systems (LIONS). École. . Polytechnique. . Fédérale. de Lausanne (EPFL). Switzerland . http://lions.epfl.ch . . joint work with . Hemant. October 28, 2016. Objectives. For you to leave here knowing…. What is the LCR model and its underlying assumptions?. How are LCR parameters interpreted?. How does one check the assumptions of an LCR model?. Assistant Professor, Division of Geriatric and Palliative Medicine. Deputy Director, Consortium on Aging. Kathleen Pace Murphy, PhD, MS, GNP-BC. Assistant Professor, UTHealth McGovern Medical School. Dr Shama Mani FRCP. Geriatrician and Dementia Lead. Barnet Hospital. Why Frailty Matters and How to find it. Definition of Frailty. Frailty scoring. Implications of scoring. What to do next. Definition of frailty. What. . is. . it. ?. Donata. . Kurpas. Jose Augusto Simoes. Jean-Baptiste . Kern. Jean-Pierre Jacquet. Frailty, is a disturbing term for GPs, because it doesn't cover a disease or an illness even a syndrome, but this term try to define patients with clinical ,social and environmental situation at risk of dependency but not only.. biology. of . aging. Marije Hamaker and Guiseppe . Colloca. Disclosure. No . conflict. of . interests. What is aging?. Defined as. Progressive loss of function. Reduced fertility. Increased risk of mortality. Clinical Director: Bettina Wan. Proposed Interventions and Outputs. Target Outcomes . Target Impact. Talking about frailty: . Tailored guidance and professional communications developed to promote . Dr Dominic Hart. Consultant Geriatrician. Belfast Trust. Frail?. Frail?. What is Frailty. “A state of increased vulnerability to poor resolution of homeostasis after a stressor event.”. NOT. An inevitable part of aging.