Zargham Riboflavin Deficiency What is Riboflavin Vitamin B2 Water Soluble Vitamin Function Important for body growth Important in red blood cell production Helps in releasing energy from carbohydrates ID: 237000
Download Presentation The PPT/PDF document "Melissa" is the property of its rightful owner. Permission is granted to download and print the materials on this web site for personal, non-commercial use only, and to display it on your personal computer provided you do not modify the materials and that you retain all copyright notices contained in the materials. By downloading content from our website, you accept the terms of this agreement.
Slide1
Melissa Zargham
Riboflavin Deficiency Slide2
What is Riboflavin?
Vitamin B-2
Water Soluble Vitamin
Function:
Important for body growthImportant in red blood cell productionHelps in releasing energy from carbohydrates
Molecular Formula: C17H20N4O6Slide3
Food SourcesSlide4
Dietary RequirementsAdequate Intakes (AI):Infants:
0 to 6 months 0.3 mg/day
7 to 12 months 0.4 mg/dayDietary Reference Intakes (DRIs):
Children1-3 years 0.5mg/day4-8 years 0.6 mg/day
9-13 years 0.9 mg/dayAdolescents & AdultsMales 14 and older 1.3mg/dayFemales 14-18 1.0 mg/dayFemales 19 and older 1.1 mg/daySlide5
Riboflavin as a cofactorMost important biologically active forms:
Flavin
adenine dinucleotide (FAD)Flavin mononucleotide (FMN
)Riboflavin is required for the processing of dietary fats, carbohydrates, and proteins to convert these nutrients to energy.
Riboflavin is also used for the continual process of renewal and regeneration of all cells and tissues in the body.FAD and FMN participate in a range of redox reactionsOxidative PhosphorylationSlide6
Oxidative PhosphorylationThe metabolic pathway that uses energy released by oxidation of nutrients to produce ATP.Slide7
Causes and diagnosisA deficiency only in riboflavin has never occurred in the natural environment.
When riboflavin deficiency is actually detected, it is often associated with low consumption of milk, chronic
alcoholism, or chronic diarrhea.Diagnosis:
Red blood cells tests are conducted
that measures the activity of an enzyme called glutathione reductase.Slide8
Riboflavin DeficiencySymptoms:
Chapping
and fissuring of the lipsSore
, red tongueOily, scaly skin rashes
Red, itchy eyesNight blindnessCataractsMigrainesPeripheral neuropathyanemia FatigueMalignancy (esophageal and cervical dysplasia)
Developmental abnormalities associated with riboflavin deficiency:
Cleft lip and palate deformities
Growth retardation in infants and
children
Congenital heart defectsSlide9
TreatmentRiboflavin deficiency can be treated with supplemental riboflavin
0.5 mg/kg body weight per
day until the symptoms disappearThe prognosis for correcting riboflavin deficiency is
excellentSlide10
ResearchCurrent research of public health relevance relates to the significance
of riboflavin as a factor in protecting against cardiovascular
diseases and cancers and in vision. Slide11
Sourceshttp://
www.nlm.nih.gov/medlineplus/ency/article/002411.htm
http
://emedicine.medscape.com/article/125193-overview#a1
http://ajcn.nutrition.org/content/77/6/1352.fullhttp://employees.csbsju.edu/hjakubowski/classes/ch331/oxphos/olcouplingoxphos.htmlhttp://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?cid=6759http://
medical-dictionary.thefreedictionary.com/Riboflavin+Deficiency
http://
www.walgreens.com/store/c/nature%27s-bounty-vitamin-b-2-100-mg-vitamin-supplement-tablets/ID=prod1177970-product