PPT-Stroke Hyperglycemia Insulin Network Effort (SHINE)

Trial Treatment Protocols Askiel Bruno MD MS Protocol PI Agenda General protocol for control group intervention group Discussion of meals H ypoglycemia protocol Pauses of study protocol. Pens. Prepared by: Alison . Deux. , 4. th. year pharmacy student. Background on Diabetes. More than 9 MILLION Canadians are living with diabetes or pre-diabetes. 20 more people are diagnosed every hour. Trial. Treatment Protocols. Askiel Bruno, MD, MS. Protocol PI. Agenda. General protocol for control group/ intervention group. Discussion of meals. H. ypoglycemia protocol. Pauses of study protocol. Pharmacoepidemiology and Drug Safety. 2008;(17):753-759.. So benefit of both SU/Insulin in. research studies –UKPDS, DCCT/EDIC. But adverse risk in ‘real world’ use. Link between hypoglycemia and acute cardiovascular events in type 2 diabetes. Trial. I-SPOT. Nina Gentile, MD. Hannah Reimer. I-SP T. O. I. nsights on . S. elected . P. rocoagulation markers and . O. utcomes in stroke . T. rial. I-SPOT. The . I. nsights on . S. elected . P. R. esistance and Diabetes. Alfred Martello, MD. Medical Director. The Ohio Anesthesia Group. Disclosures. No Commercial endorsements. I’m not really smart enough to give this lecture.. It’s really complicated stuff.. National Institute of Health Stroke Scale. Yvonne Skewis, RN, BSN, SCRN. Purpose. Standardize neurological exams in acute care stroke patients. High reliability and validity. 15 components, score ranging from 0-42. 1. Overview. 2. Inpatient Hyperglycemia and Poor Outcomes in Numerous Settings. Study. Patient Population. Significant Hyperglycemia-Related Outcomes. Pasquel et al, 2010. Total parenteral nutrition. Yvonne Skewis, RN, BSN, SCRN. Purpose. Standardize neurological exams in acute care stroke patients. High reliability and validity. 15 components, score ranging from 0-42. Higher numbers= poor neurological outcome. Anne Marie Mattingly. Assistant Professor of Medicine. Division of Pulmonary and Critical Care. September 22, 2014. Goals of Treatment. Accurately diagnose DKA and/or HHS. Provide optimal volume resuscitation. Network Effort (SHINE) Trial . NIH-NINDS . U01 . NS069498. An Overview of SHINE. Contents. Background. Trial Overview. Treatment Groups. Outcomes. I-SPOT Ancillary Study. SHINE Background. Most animal stroke studies show that hyperglycemia at stroke onset leads to worse outcomes than . A Review of the Basic Science. 1. Prevalence of Hyperglycemia in Critically Ill Patients. 2. CIAH, critical illness associated hyperglycemia.. Plummer MP, et al. . Intensive Care Med. . 2014;40:973-980.. Members - June . 25, 2014. The Stroke Hyperglycemia Insulin Network Effort (SHINE) Trial. NIH-NINDS . U01 . NS069498 . NETT . CCC U01 . NS056975 NETT . SDMC U01 NS059041. Toll free dial-in number: (888) 242-1836 . Melissa Ashdown BSN, CDE, CPT. G. Denise Cooks, MSN, CPNP-PC, CDE, CPT. Objectives. Understand the difference between Continuous Glucose Monitors and Insulin Pumps. Describe hyperglycemia and hypoglycemia. What effect does glycemic control with insulin have on these complications?. None. . Insulin does not improve mortality rates/neurological outcomes after stroke. Why do we care?. Stroke is the 5. th.