PPT-Covariate selection strategies,

Negative controls and Empirical calibration Martijn Schuemie Janssen RampD OHDSI UCLA Trouble with observational research 2 Residual study bias 3 Rush et al 2018 How to choose covariates to adjust for. Prepared for:. Agency for Healthcare Research and Quality (AHRQ). www.ahrq.gov. This presentation will:. Describe the data source(s) that will be used to identify important covariates. Discuss the potential for unmeasured confounding and misclassification. Examining standard approaches to randomized Experiments. Tyler Hicks, Ph.D.. University of Kansas. Jeff Kromrey, Ph.D.. University of South Florida. Control. Treated. Were the Comparison Groups Equivalent?. Neelesh B. . Mehta. ECE Department, IISc. New Project Proposal. Outline. Research problem and applications . Proposed approach. Author. ’. s previous work in this area. Project milestones. Budget estimates. CS838. . Motivation. Old school related concept:. Feature scaling . T. he . range of values of raw . training data often varies widely. Example: Has kids feature in {0,1}. Value of car: $500-$100’sk. Kari Lock and Don Rubin. Harvard University. JSM 2010. The “Gold Standard”. Why are randomized experiments so good?. . They yield unbiased estimates of the treatment effect. They eliminate (?) confounding factors…. What is an Experiment?. Campbell & Stanley stressed random assignment to experimental treatments.. I stress manipulation of the independent variable.. Quasi-Experiments: C&S’s term for research where. Design and Analysis. STA 320. Design and Analysis of Causal Studies. Dr. Kari Lock Morgan and Dr. Fan Li. Department of Statistical Science. Duke University. Covariates. Pre-treatment variables. X: n x k covariate matrix. Laura Gibbons, . PhD. Thanks to . An Introduction to Survival Analysis Using . Stata. Acknowledgement. Funded in part by Grant R13 AG030995 from the National Institute on Aging. The views expressed in written conference materials or publications and by speakers and moderators do not necessarily reflect the official policies of the Department of Health and Human Services; nor does mention by trade names, commercial practices, or organizations imply endorsement by the U.S. Government.. The Gory Details. (Or, how to be a helicopter parent to a neural network). (Or, why AI is not about to be solved any time soon). Outline. Optimization. Mini-batch SGD. Learning rate decay. Adaptive methods. Applicability of Radiation-Response Models to Low Dose Protection Standards. October 2, 2018. Alia Zander. Dose and Dose Rate Effectiveness (DDREF) estimates. Research Institution. DDREF Value. United Nations Scientific Committee on the Effects of Atomic Radiation (UNSCEAR). www.maizegenetics.net. /tassel. Sequence . Hapmap. data format. Hapmap. is a text based file format for storing sequence data.. Information on the SNPs as well as germplasm/lines/. varities. are stored in one file. . A Selection of Continental Meats & Cheeses. A Selection of Cereals. Greek Yoghurt With a Selection of Toppings. Fresh Fruit. Blue Berry Muffins. . Cooked Breakfast. Cheese on Toast. Hash Browns . Cohort Entry Date. May 1, 2016. Jul 1. Sep 1. Nov 1. Jan 1. Hospital Stay. Follow-up Window. Dx. V. Rx. Lab. Rx. Rx. V. Dx. Figure 1: From transactional data to study implementation*. Individual-patient data is documented as encounters from various sources, including diagnoses/procedures (Dx/. Figure 2. . PS distributions, covariate balance, empirical null distribution calibration plots for the (primary) heart failure analysis in Optum DOD. Table 1. . Analysis variations that yield 600 unique effect estimates.