Knowledge Graphs and Large Language Models for
Author : cheryl-pisano | Published Date : 2025-05-29
Description: Knowledge Graphs and Large Language Models for Adult ADHD Grigoris Antoniou Leeds beckett university Motivation Ive been prescribed with methylphenidate but recently Ive been experiencing severe insomnia This is a common side effect of
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Knowledge Graphs and Large Language Models for Adult ADHD Grigoris Antoniou Leeds beckett university Motivation I’ve been prescribed with methylphenidate but recently I’ve been experiencing severe insomnia. This is a common side effect of methylphenidate. Are there stimulants with similar effects but less frequent reports of insomnia? Web Search (not so reliable) Publications on stimulants and insomnia 58 results only on adult ADHD! Clinical Trials that tested stimulants on adults with ADHD (18 results) Medication with similar response but less effects on sleep (sources?) I need HELP! I’ve been prescribed with methylphenidate but recently I’ve been experiencing severe insomnia. This is a common side effect of methylphenidate. Are there stimulants with similar effects but less frequent reports of insomnia? Web Search (not so reliable) Publications on stimulants and insomnia 58 results only on adult ADHD! Clinical Trials that tested stimulants on adults with ADHD (18 results) Medication with similar response but less effects on sleep (sources?) Answering this question requires plenty of manual effort. Retrieve and link information from different medical resources. Can AI-powered methods automate this process? ADHD-specific Knowledge Graph KGs in Medical Sciences A collection of interlinked concepts, relations and events Extensively used in medical domains Knowledge representation Integration of multiple medical resources Searching about things not strings Knowledge discovery, denoising, forecasting and much more… Data Resources for ADHD-KG PubMed Publications in biomedical and life sciences Clinical trials Repository of medical studies DrugBank Detailed collection of drug data with drug target information. SIDER Collection of recorded adverse effects caused by marketed medicine MeSH Extensive thesaurus of medical concepts Information Linking Direct: explicit references to resources Clinical trials might cite publications (vice versa) Resources contain MeSH references MeSH: methylphenidate Publication: PID-123 C. Trial: CT-1 Ext. references: PID-123 Drug-id: ID-1 Name: methylphenidate MeSH: methylphenidate DrugBank SIDER SIDER-id: ID-3 Name: methylphenidate Ext. reference: Drug-id: ID-1 Side effect: Insomnia, 15% ADHD-KG Architecture Demonstration - Comorbidities Most frequent comorbid mental disorders found in ADHD literature Traverse MeSH to retrieve labels of mental disorders Filter publications that contain explicit references or semantic annotations referring to disorders Demonstration - Sleep Deprivation & Stimulants Demonstration - Medicines & Receptors GPT & Friends - Large Language Models Can engage in conversations with humans Can be used for decision support and decision making LLM in medicine Can potentially assist clinicians in decision making Can potentially provide advice to patients But is it safe? Validation of LLM & ADHD-KG
