Targeted ICG-Nanobubbles for Detection of Pancreatic Cancer Jared Alvarez, Chris McGovern, Li-Chong Xu, Chris Siedlecki, Gail Matters Introduction Pancreatic ductal adenocarcinoma is one of the deadliest forms of cancer Detection Treatment
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Presentation Transcript
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Targeted ICG-Nanobubbles for Detection of Pancreatic Cancer Jared Alvarez, Chris McGovern, Li-Chong Xu, Chris Siedlecki, Gail Matters<br>
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Introduction Pancreatic ductal adenocarcinoma is one of the deadliest forms of cancer
Detection
Treatment resistance https://utswmed.org/medblog/pancreatic-cancer-nutrition/<br>
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Photoacoustic imaging is a promising biomedical tool Han, S. H. (2018). Review of Photoacoustic Imaging for Imaging-Guided Spinal Surgery. Neurospine, 15(4), 306-322. doi:10.14245/ns.1836206.103<br>
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Hypothesis Photoacoustic imaging will improve early detection of pancreatic cancer.
Targeted PLGA nanobubbles will improve photoacoustic image contrast and sensitivity. My Goal Optimize synthesis of Indocyanine green (ICG) loaded PLGA nanobubbles
Quantify ICG encapsulated in loaded PLGA nanobubbles<br>
Emulsions Two normally immiscible liquids mixed through dispersion
Emulsion within an emulsion Water/oil/water multiple emulsion Water in oil single emulsion<br>
Future directions Quantifying aptamer attachment
Zeta potential
Picogreen
Quantifying particle fluorescence lifetime
In vitro testing
In vivo testing<br>
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Acknowledgements Matters Lab
Dr. Gail Matters
Chris McGovern
Laura Felix
Delphin Monga
Siedledki Lab
Dr. Li-Chong Xu
Dr. Chris Siedledki
TEM Core
Dr. Han Chen
Collaborators
Dr. Sri-Rajasckhar Kothapalli
Sumit Agrawal
Ajay Dangi
STEP-UP
Dr. Bonnie Halpern-Felsher
Sheila McLaughlin
Mentors
Theresa Swenson
Dr. KC Ang
Dr. Marnie Halpern
The STEP-UP HS program is supported by the National Institute of Diabetes and Digestive and Kidney Diseases of the National Institutes of Health Grant #: 2R25DK078382-12<br>
