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http://www.journal-imab-bg.org PRECIPITATED WITHDRAWAL REACTION TOOPIATES IN CASES OF IMPROPER USE OFNALTREXONE Department of Toxicology Hospital Base for Active Treatment- Varna, Military Academy- Sofia, Annual Proceeding (Scientific Papers) SUMMARY Key words: naltrexon, opioid, withdrawal,addiction. INTRODUCTIN: Naltrexone / trade names Re Via; Nalorex, etc. All the cases we describe are from the firstgroup- accidental precipitation of withdrawal becauseof serious failure to observe the treatment protocol.According to it the patient should be opioid-free atthis safety instruction has not been followed a severe http://www.journal-imab-bg.org Verification of an opioid-free state is made by been treated at the Department of Toxicology, NavalHospital-Varna, with Naltrexone precipitated opiatewithdrawal. 5 of them were in-patients and 11, whorefused hospitalization, ambulatory out-patients. All ofthem admitted taking ReVia or Nalorex before 10- DESCRIPTION OF HOSPITAL CASES: I.K.P., 23 years old, male, HR¹1375allover the body, seizures, uncontrolled psychomotorexcitation, fever, raised temperature to 38.2 degrees C.He was admitted in Toxicology Department 3 hours G.K.P., 23 years old, female, HR¹Co morbidity- Anorexia nervosa. Last dose Heroine on15.04.01, ¼ tablet- 12.5 mg daily. On 14.04.01q afterabdominal cramps. Treated with benzodiazepines. Onwas admitted in Toxicology Department with vomiting, gastritis. Atrophy of the stomach wall. Shock kidneys.Shock lungs. A lot of dark pigment in both lungs. O.A.T., 20 years old, male. HR¹4770Naltrexon therapy. Both tests were negative and hewas approved to start Nalorex the next day. Ondiarrhea, abdominal and muscle cramps, fever,excitation, one big tonic-clonic seizure. Transported V.D.I., 22 years old, male. HR¹2838and frightened. HR 100/min., RR 180/90. Ambulatorymainly CNS expression. Two days later the patient was A.V.N., 24 years old,female.10.10.2005. Addiction to Heroin anddose naltrexon. 30 minutes after the first ½ tabl. ReViachills, fever, headache, nausea, muscle stiffness and Description of the ambulatory cases. 11 patients : http://www.journal-imab-bg.org day. All the 11 patients took continuously treated in the Intensive Care Unit of the ToxicologyDepartment. Vital signs were monitored from 16 to 72hours. Treatment was carried out with benzodiazepinesby scheme IM and IV, cerebroprotectors- nootropics, DISCUSSION: been kept properly. All the patients had some them. All the patients had taken the first dose naltrexonambulatory. 4 of the hospitalized patients and 2 of the CONCLUSION: As other strong acting treatments, the naltrexontreatment of opioid addiction should start either in aobservation from medics and relatives until a successful N.Ed. Principles of Addiction detoxification. Br.J.Hosp. Med.38;79- 3. Constitutive opioid receptor REFERENCES: Freye, J.V.Levy, Addiction Biology vol. 4. Naltrexon LAI, 2004-10-30.Medline. 5. Revia- drug information-RxList-The Internet Drug Index, 2005. 6. ReVia /formerly Trexan/- last 7. Nalorex- Summary of ProductsCharacteristics from the eMC-lastrevise 26/10/2005. University, 06/ 2001 Address d-r Marieta Jovcheva Department of Toxicology, BBAL - Varna; 3, Hristo Smirnenski Str., Varna, Bulgaria E-mail: rieta_js22@yahoo.com;