PPT-Neurotransmitter-coumarin derivatives as potential SARS-CoV-2 main protease inhibitors

Dejan Milenković 1 Dušan Dimić 2 Edina Avdović 1 Jelena Đorović Jovanovi ć 1 Žiko Milanović 3 Marko Antonijević 1 Jasmina DimitrićMarković. Mark Sulkowski, MD. Associate Professor of Medicine . Johns Hopkins University School of Medicine . Limitations of PegIFN + Ribavirin . (with or without protease inhibitors). Antiviral activity is host + virus genotype dependent . presynaptic ending – . portion of the . axon . conveying information to the next neuron. . Some terms…….. presynaptic ending – . the portion of the axon that is conveying information to the next neuron. Stereochemistry. Many biomolecules, including proteins, carbohydrates and DNA, are chiral. . A typical drug molecule acts by docking with a target biomolecule such as an enzyme or receptor. These drugs are often chiral, and the two enantiomers may differ greatly in efficacy.. Stereochemistry. Many biomolecules, including proteins, carbohydrates and DNA, are chiral. . A typical drug molecule acts by docking with a target biomolecule such as an enzyme or receptor. These drugs are often chiral, and the two enantiomers may differ greatly in efficacy.. One sneeze can generate an aerosol of enough cold viruses to infect thousands of people!. Treatment of . Herpesviruses. . Varicella-zoster,. Cytomegalavirus,. Herpes simplex. Anti-metabolites . . “False” DNA building blocks . Shaw Vonder Hoya. Worldwide Prevalence. Types of HIV. HIV type 1:. Most common. Originated from chimpanzee SIV. High infectivity and virulence. HIV type 2:. Mostly confined to West Africa. Came from sooty . Explain the role of calcium ions. Explain the role of neurotransmitters. Explain the role of . acetylcholinesterase. The Basic Idea. Synapses are gaps . between neurones . 20-30nm. . wide. Information is sent . Peptidase . IV (DPP4) . Inhibitors . as . Potential Agents . to treat SARS-CoV-2 (2019-nCov) . Infection. DPP4 activity is increased in patients with type-2 diabetes and the increased risk of type-2 diabetic patients to SARS-CoV-2 infection, which suggests that DPP4 class of drugs have the potential to be used as novel therapy. Our molecular modeling studies suggest that. A drug repurposing approach for COVID-19. Md. Riad Chowdhury. 1. , . Md. . Adnan. 2,*. , . Md. Nazim Uddin . Chy. 1,*. , . A.T.M. Mostafa Kamal. 1. 1. Department of Pharmacy, International Islamic University Chittagong, . Dina. saleem. Coumarin. The interaction between . salicyldehyde. . and acetic anhydride in the presence of sodium acetate results into the formation of the heterocyclic . pyran. ring to give . coumarin. Department Medicine. UF College of Medicine. Randomized trial of bicalutamide to block . TMPRSS2 in males with COVID-19 infection. UF-CTSI Pilot grant project. Association between . Cancer and COVID-19 Biology. DEPARTMENT OF CHEMISTRY. D.D.U. GORAKHPUR UNIVERSITY. GORAKHPUR. ACKNOWLEDGEMENT. I bow before the . electic,divine. and blessing forces (parents and teachers).. Who made me worthy of doing this scared job to completion.. Virupaksha. A. Bastikar. 1. ; . Pramodkumar. Gupta. 2. ; Alpana V. Bastikar. 3. and Santosh S. Chhajed. 4. 1. Amity Institute of Biotechnology, Amity University, Mumbai, Maharashtra;. 2. School of Biotechnology and Bioinformatics, D. Y. . Also Called . 3CL Proteinase. Collaborative Curriculum Development Program 2020. What does SARS-CoV-2 look like? . Severe acute Respiratory Syndrome -Coronavirus-2. Large (~30Kb) . +RNA genome. . https://viralzone.expasy.org/764?outline=all_by_species.