PPT-NEOPLASIA (New growth) DR.AYSER HAMEED

LEC1 Abnormal mass of tissue characterized by followings Its growth is uncoordinated amp exceeded with that of the normal tissues Neoplasm persist its growth after the cessation of stimuli which cause the change. OBJECTIVES/RATIONALE. A neoplasm is an abnormal growth of tissue that may be benign or malignant. The student will identify terms related to neoplasia, classifications of tumors, and grading and staging of cancer.. Today’s Frontier. CNS Neoplasia- -Dogs. Common Types. Meningioma. Astocytoma. Oligodendroglioma. Choroid plexus . papilloma. Lymphoma. Neuroectodermal. tumors. Metastatic tumor. CNS Neoplasia- -Dogs. A neoplasm is an abnormal growth of tissue that may be benign or malignant. The student will identify terms related to neoplasia, classifications of tumors, and grading and staging of cancer.. Cancer Statistics. INTRAEPITELIAL (VIN) Para la citación de la presente AEPCC-Guía se hará constar: “AEPCC-Guía: Neoplasia vulvar intraepitelial (VIN). Publicaciones AEPCC, noviembre 2015” ISBN 978-84 DroughtandfoodsecurityinthemiddleeastAnanalyticalframeworkMaysounHameedAliAhmadalipourHamidMoradkhaniCenterforComplexHydrosystemsResearchDepartmentofCivilConstructionandEnvironmentalEngineeringUnivers LEC.2. Most benign tumors grow slowly . & most of cancers grow faster . & eventually spread locally & to distant sites (metastasis) & causing death.. In some exception, some benign tumors grow more rapidly than some cancers e.g. leiomyoma (uterine fibroid), which is benign smooth muscle tumor influence by estrogen & so increase in size during pregnancy.. LEC.1. General Features . Inflammation is defined as "the response of living . vascularized. tissues to harmful agents.”. . It consists principally of vascular changes associated with leukocytes infiltration and systemic reactions. LEC.2. Binding of a particle to . phagocytic. leukocyte receptors initiates the process of active . phagocytosis. .. During engulfment, extensions of the cytoplasm (. pseudopods. ) flow around the particle to be engulfed, eventually resulting in complete enclosure of the particle within a . Dr. . Heym. . Awad. MD, . FRCPath. ILOS. 1. Understand that insensitivity to growth inhibition is an important cancer hallmark.. 2. List the tumor suppressor genes that if mutated result in this insensitivity.. LEC.4. Examples of tumor suppressor genes:. 1. RB gene:. This is the . first discovered suppressor gene. , . loss of normal RB gene was discovered initially in Retinoblastoma, but recently proved it lost in many tumors (breast cancer, bladder & lung cancer, osteosarcoma).. LEC.3. Incidence of cancer. In male. . 30% Carcinoma of prostate. .. 14% Carcinoma of Lung.. 11% Carcinoma of colon & rectum.. In female. . . 31% breast carcinoma. .. 12% carcinoma of lung. . LEC.5. Chemical carcinogenesis:. General principles of chemical carcinogens;. I. . Could be . natural or synthetic chemical. ..  . II. . Chemicals either . direct acting chemical. (. active without transformation in the body). LEC.4. Carcinogenesis:. is a multistep process at both . phenotypic & genetic levels.. Phenotypic level . includes:. I. Excessive growth.. II. Local invasion.. III. Metastasis.. These three criteria are called collectively . LEC.5. 3. Evasion of apoptosis:. Normally, . the mechanism of . apoptosis is mediated by many genes, & achieve by two phases. . Initiation phase. , which is mediated by . TNF- Fas receptor . & inhibited by FLIP protein..