PPT-Gene duplications : PSEUDOGENES

Alba Vilella Figuerola Genomics MSc in Advanced Genetics Universitat Autònoma de Barcelona OVERVIEW What are pseudogenes How do they arise Pseudogenes and evolution. Ron Zeira. and Ron Shamir. Combinatorial Pattern Matching 2015. 30.6.15. G. enome rearrangements. Motivation I: evolution. Human genome project. Motivation II: cancer. NCI, 2001. Normal karyotype. MCF-7 breast cancer cell-line. Made famous by S. Ohno, who suggested WGD can be a route to. . evolutionary innovation (focusing on . neofunctionalization. ). Ohno proposed in the 1970s that vertebrate lineage underwent two WGDs . MUTATION. The genetic substrate for natural selection. AND the . Raw Material. for Evolution. Dr. Carol E. Lee, University of Wisconsin. (1). . Reduction of Variation: . Genetic . Drift . . . Inbreeding . RNAi, Gene Expression & Gene Editing Application Note GE Healthcare Figure 1. Effects of miRIDIAN miR-122 Mimic and Hairpin Inhibitor on endogenous levels of ALDOA as measured by branched DNA assay. D in the Human Genome. Redon et. al.. Presentation By. Nguyen Dinh. Samer Metri. What are CNVs?. CNVs are segments of DNA that are 1kb or larger and show up at variable copy numbers.. CNVs can include both deletions and duplications. Ron Zeira. and Ron Shamir. Combinatorial Pattern Matching 2015. 30.6.15. G. enome rearrangements. Motivation I: evolution. Human genome project. Motivation II: cancer. NCI, 2001. Normal karyotype. MCF-7 breast cancer cell-line. God. Eve. Noah. Bible “Scientists”. “Junk DNA”. H. umans are estimated to have approximately 20,000 protein-coding genes which account for only about 1.5% of DNA in the human genome. The primary goal of the encode project is to determine the role of the remaining component of the genome, much of which was traditionally regarded as "junk" (i.e. DNA that is not [used to make protein]).. (Questions. , . Answers. , . and . M. ore Questions). Elspeth Bruford. continue . naming of human protein-coding genes, . pseudogenes. & RNA genes. continue reassignment of uninformative symbols based on functional data. Can use Access or Excel. Exact . duplicates: Same-same-same. Close duplicates: . Same-same-different. Prepared by:. Mark J. Nigrini. Copyright © 2012 by Mark J. Nigrini. All rights reserved.. introduction. Ariadna Pedraza Mensa. Genomics, 2017 . Master’s Degree in Advanced Genetics - UAB. Origin of new genes. DNA-based gene duplication (segmental duplications). Ohno’s model for duplications fate. RNA-based gene duplication (. direct. or . inverted . and is indicated by the order of the bands with respect to the centromere in the karyotype designation. . The band closest to the centromere is written first in the short system; only the detailed system can pinpoint the exact location of the duplicated segment.. (Outline the number of unique genotypes candidates for AEGIS in your country having into account the Guidelines.. Indicate the number of candidates with safety duplications in other(s) repositorie(s)). Loren Hauser. Miriam Land. Yun-Juan Chang. Frank Larimer. Doug Hyatt. Cynthia Jeffries. NEB Educational Support. 2. http://www.neb.com/nebecomm/course_support.asp?. Why study Computational Biology. . Genetic Drift is main force for changing allele frequencies. How do you define evolution?. Richard Goldschmidt 1940. hopeful monsters. Mutationism. . HGT/WGD!. Punctuated Equilibrium. Few genes / large effect.