PPT-Gene duplications: evolutionary role

Ariadna Pedraza Mensa Genomics 2017 Masters Degree in Advanced Genetics UAB Origin of new genes DNAbased gene duplication segmental duplications Ohnos model for duplications fate RNAbased gene duplication . Ron Zeira. and Ron Shamir. Combinatorial Pattern Matching 2015. 30.6.15. G. enome rearrangements. Motivation I: evolution. Human genome project. Motivation II: cancer. NCI, 2001. Normal karyotype. MCF-7 breast cancer cell-line. Made famous by S. Ohno, who suggested WGD can be a route to. . evolutionary innovation (focusing on . neofunctionalization. ). Ohno proposed in the 1970s that vertebrate lineage underwent two WGDs . Vibrio cholerae . HHMI 2011. Sara Fassio. Dr. Claudia H. ä. se. Dr. Yusuke Minato . Cholera. Infection of small intestine . Causes severe diarrhea and electrolyte loss. 3-5 million cases a year. 100,000- 120,000 deaths per year . Have a negative role in cell division. Have a role in the maintenance of DNA integrity. Genes altered in cancer typically:. Tumor Suppressor Genes. Not enough of a good thing….. 1 / 10. 6. 1 / 10. 6. Ron Zeira. and Ron Shamir. Combinatorial Pattern Matching 2015. 30.6.15. G. enome rearrangements. Motivation I: evolution. Human genome project. Motivation II: cancer. NCI, 2001. Normal karyotype. MCF-7 breast cancer cell-line. Yue Zhang, . Chunfang. Zheng, David . Sankoff. Presented by Suzy Sun . Seeks to infer the nature and timing of evolutionary events by examining the distribution of similarities between orthologous and paralogous gene pairs . Can use Access or Excel. Exact . duplicates: Same-same-same. Close duplicates: . Same-same-different. Prepared by:. Mark J. Nigrini. Copyright © 2012 by Mark J. Nigrini. All rights reserved.. introduction. Michael Specter. The New Yorker. December 3, 2007. Presented by. Patrick Wu. 20.385 Advanced Topics in . Sy. nthetic. Biology. May 10, 2011. Background of Viruses. Genetic material within protein capsid. direct. or . inverted . and is indicated by the order of the bands with respect to the centromere in the karyotype designation. . The band closest to the centromere is written first in the short system; only the detailed system can pinpoint the exact location of the duplicated segment..  . Unit 11. 7F. Let’s remember…. An allele is an alternative form of one gene . B stands for black b stands for brown. The allele would be…. Genetic Drift. An evolutionary mechanism in which allele frequencies change in a population. 2. Behavior Genetics and Evolutionary Psychology. Module 8. 3. Behavior Genetics: Predicting Individual Differences. Genes: Our Codes for Life. Twin and Adoption Studies . Temperament, Heredity, and Personality. Alba Vilella Figuerola. Genomics. MSc. in Advanced . Genetics. Universitat Autònoma de Barcelona. OVERVIEW. What. . are. . pseudogenes. ?. How. do . they. . arise. ?. Pseudogenes. . and. . evolution. �� �� . Phylogenetic relationships and estimated divergence times of major lineages in the genus Drosophila. Taxa in bold are pr Genetic Drift is main force for changing allele frequencies. How do you define evolution?. Richard Goldschmidt 1940. hopeful monsters. Mutationism. . HGT/WGD!. Punctuated Equilibrium. Few genes / large effect.