PPT-Credibility in multiscale modeling of bone environment response to metastatic cancer

David Basanta and Conor Lynch The problem A Osteoclastogenesis Monocyte Macrophages Osteoclast Osteolysis Osteogenesis MMP BMP MMP MMP BMP Osteoblast MSC and OB Precursors Inflammatory Macrophages. in bone. Content. Introduction. Epidemiology. Pathogenesis. Clinical features. Diagnosis. Management. Medical management . Surgical management. Introduction. Introduction. The skeleton is a common site for metastatic spread from epithelial . Gaorav. P. Gupta and Joan . Massague. Gabriella F. de Paz and Susana S. . Hak. Fall 2011, 20.309. An Evolutionary Metaphor. Evolution = environmental stresses select for organisms with advantageous survival traits. Alexandre . Iscaife. ; Denis Reis Morais; Sabrina Thalita Reis; Nayara Izabel Viana, . Andre. . Bordini. ; Daniele . Janolli. ; Nelson . Dip. ; Miguel . Srougi. ; Katia Ramos Moreira Leite . Laboratory of Medical Research – LIM 55, Urology, University of Sao Paulo, Sao Paulo, Brazil. Medical University of South Carolina . Charleston, SC. Bones, Hot Flashes, and ADT Use With Chemotherapy and Timing. Toxicities of ADT. Hot Flashes, sexual dysfunction and many other complications of therapy are seen in greater than 90% of men on ADT. Sipuleucel. -T was approved based on HR of 0.775 . (~4-month OS benefit). Survival curves separated after 6 months. Significant PSA decline rate ~3%. No improvement in time to progression. Very few side effects. ADVANCED PROSTATE CANCER: BONE ISSUES AND METASTASES Samuel Denmeade, MD Professor of Oncology, Urology and Pharmacology The Johns Hopkins University School of Medicine Castrate-sensitive Non-Metastatic Cancer and Sarcoma Vocabulary Lesson Gina D’Amato, MD Director of Clinical Research Georgia Cancer Specialists affiliated with Northside Hospital Cancer Institute Definition of Cancer Cancer is the uncontrolled growth of abnormal cells in the body Charleston, SC. Bones, Hot Flashes, and ADT Use With Chemotherapy and Timing. Toxicities of ADT. Hot Flashes, sexual dysfunction and many other complications of therapy are seen in greater than 90% of men on ADT. Breast Cancer : How important is it? . It is the most common cancer among women in lower-and-middle-income in Asian countries. . Its cost to society in terms of . - use of healthcare resources . Median PFS: 1.4 months (95% CI, 1.2-1.6) . Median PFS: 1.2 months (95% CI, 0-4.7) . A.. B.. C.. Cancer . Prior to TAS-117 (n=13). TAS-117 (n=13). Subsequent line of treatment (n=6). Breast cancer . 3. Francesco GIAMMARILE. « . Aut tace aut loquere meliora silentio.  ». Bone scan and F-Choline . Radionuclide treatment . Presentation Outline. Introduction. NO CONFLICT OF INTEREST. General aspects. Elana Plotkin, CMP-HC. 1. , Marianne Gandee, MA. 2. , Lorna Lucas , MSM. 1. 1 Association of Community Cancer Centers, Provider Education, Rockville, MD, USA 2 Association of Community Cancer Centers, Development, Rockville, MD, USA. Jeanny B. Aragon-Ching, M.D., F.A.C.P.. Clinical Program Director of Genitourinary Cancers, Inova . Schar. Cancer Institute. Associate Professor of Medicine, Virginia Commonwealth University. October 13, 2018. Director, Precision Medicine Research for Liquid Biopsies. pmk4001@med.cornell.edu. . @pashtoonkasi. Other Therapeutic Considerations . in Colorectal Cancer. 1. Malla M, Loree JM, Kasi PM, Parikh AR..