PPT-Metastatic Breast Cancer: A Medical Update

Jennifer M Matro MD Rena Rowan Breast Center Abramson Cancer Center University of Pennsylvania Overview What is metastatic breast c ancer MBC Who is at risk Subtypes of Breast Cancer. nbcamorg reast cancer is the second most common kind of cancer in women About 1 in 8 women born today in the United States will get breast cancer at some point The good news is that many women can survive breast cancer if its found and treated earl Elaine R. Mardis, Ph.D.. Professor of Genetics. Co-director, The Genome Institute. NCI Workshop: NGS in Clinical Decision Making. Why is cancer WGS analysis “easy”?. The comparison of a patient’s tumor to their normal genome . . Dr.Mina. . Tajvidi. Radiation . oncologist. . Fewer than 10 percent of women present with metastatic disease at the time of diagnosis. the majority of women who relapse after definitive therapy for early stage or locally advanced disease will do so with disseminated metastatic disease rather than an isolated local recurrence. Targeting endocrine-resistance pathways in breast cancer Clara Natoli, Chieti Endocrine responsive breast cancer Luminal A High expression of ER & ER-related genes Lower Management of HER2 Over-Expressed Breast Cancer in the Adjuvant, Neoadjuvant, and Metastatic settings Christy A Russell, MD Keck School of Medicine University of Southern California Metastatic Breast Cancer BRCA2 is a tumor suppressor gene responsible for DNA repair . BRCA2 was discovered in breast cancer tumors of patients without BRCA1 mutations. Mice knockouts discovered that BRCA2 is directly involved in double strand break repair. Christine Lauro, MD. Radiation Oncologist. April 21, 2018. Outline. Epidemiology. Breast Cancer Risk Factors/Symptoms. Benefits of Screening. Review of Guidelines. Epidemiology. Epidemiology. The chance of developing an invasive breast cancer at some time in a woman’s life is about 1 in 8 (12%).. group. of diseases. . All forms of cancer cause cells in the body to change and grow out of control. . Most types of cancer cells form a lump or mass called a . tumor. . . The tumor can invade and destroy healthy tissue. Cells from the tumor can break away and travel to other parts of the body. There they can continue to grow. . World Congress on Breast Cancer . . Birmingham, UK. . August , 2015. Yvonne Paterson, Ph.D. ., University of Pennsylvania, USA. Nicola Mason, . B.Vet.Med. , . PhD, University of Pennsylvania . Most of these lesions are benign. Breast cancer is 2. nd. most common cause of cancer deaths in women, following. carcinoma of the lung. . The clinical significance of the . benign. conditions:. 1- possible clinical confusion with malignancy. 20 1 2 , 3 http://www. jcancer .org 328 J J o o u u r r n n a a l l o o f f C C a a n n c c e e r r 20 1 2 ; 3 : 328 - 332 . doi: 10.7150/ jca . 4735 Mini - Re view Infiltrating Lobular Carcinoma of Key recommendations. 1. National and local workforce planning is essential. Health Education England and all Cancer Alliances should urgently ensure there are enough healthcare professionals to deliver high-quality and timely diagnosis, treatment and care to local women.. Elana Plotkin, CMP-HC. 1. , Marianne Gandee, MA. 2. , Lorna Lucas , MSM. 1. 1 Association of Community Cancer Centers, Provider Education, Rockville, MD, USA 2 Association of Community Cancer Centers, Development, Rockville, MD, USA. Jo Anne Zujewski, M.D.. June 2019. Thimphu. , Bhutan. Define the breast cancer. Is the cancer operable?. Stage 1: systemic therapy after surgery (and radiation if breast conservation). Stage 2: systemic therapy before or after therapy.