BRCA2 is a tumor suppressor gene responsible for DNA repair BRCA2 was discovered in breast cancer tumors of patients without BRCA1 mutations Mice knockouts discovered that BRCA2 is directly involved in double strand break repair ID: 776628
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Slide1
Breast cancer occurs when cells proliferate uncontrollably in breast tissue
Slide2BRCA2 is a tumor suppressor gene responsible for DNA repair
Slide3BRCA2 was discovered in breast cancer tumors of patients without BRCA1 mutations
Slide4Mice knockouts discovered that BRCA2 is directly involved in double strand break repair
Slide5BRCA2 combines with BRCA1 and RAD51 in response to DNA double strand breaks
Slide6BRC repeats of BRCA2 attach to Rad51 monomers to connect it to DNA
Slide7All germ line BRCA2 mutations identified to date have been inherited, suggesting the possibility of a large “founder” effect
Population or subgroup
BRCA2
mutation(s)
Ashkenazi Jewish
6174delT
Dutch
5579insA
Finns
8555T>G, 999del5, IVS23-2A>G
French Canadians
8765delAG, 3398delAAAAG
Hungarians
9326insA
Icelandics
999del5
Italians
8765delAG
Northern Irish
6503delTT
Pakistanis
3337C>T
Scottish
6503delTT
Slovenians
IVS16-2A>G
Spanish
3034delAAAC(codon936),
9254del5
Swedish
4486delG
Slide8Olaparib combats the BRCA2 mutations by helping cause cell death
Slide9Sources
https://www.cancer.org/cancer/breast-cancer/about/what-is-breast-cancer/_jcr_content/par/image.img.gif/1482250472378.gif
http://www.publichealth.org/wp-content/uploads/2014/12/Cancer-Image-I.-Leading-Cancers.png
http://www.nature.com/onc/journal/v22/n37/images/1206678f3.jpg
https://image.slidesharecdn.com/basicintroductiontotheroleofgeneticsinbreastcancerdevelopmentandtreatment-13045837154577-phpapp02/95/basic-introduction-to-the-role-of-genetics-in-breast-cancer-development-and-treatment-15-728.jpg?cb=1304565800
https://upload.wikimedia.org/wikipedia/commons/2/2e/BRCA_Genes.svg
https://upload.wikimedia.org/wikipedia/commons/c/c2/PBB_Protein_BRCA2_image.jpg
https://upload.wikimedia.org/wikipedia/commons/d/dc/Homologous_recombinational_repair_of_DNA_double-strand_damage.jpg
Br J
Clin
Pharmacol
. 2016 Jan; 81(1): 171–173.
Published online 2015 Oct 24.
doi
:
10.1111/bcp.12761