PPT-Revisiting the Therapeutic Potential of Leptin

David Litzinger PhD Director Pharmaceutical Sciences Amylin Pharmaceuticals Inc 2011 AAPS National Biotechnology Conference San Francisco CA Leptin History 1950 Obese mice appear randomly in a colony at Jackson Laboratory. Aaron Cheatham. Fat is just what we thought. The cause of excess subcutaneous and visceral fat deposition in an individual is the cumulative effect of an imbalance between the energy of ingested food and that expended in the course of daily activities. Shinichi Oka, PhD. Department of Cell Biology and Molecular Medicine. Rutgers New Jersey Medical School. MSB-I543. okash@njms.rutgers.edu. Objectives. Leptin. . Resistance. Obese. Insulin . Resistance. February 19-21. Founded in 2003. Located in Saskatoon, SK . Focused . o. n linking DNA technologies with animal traits of economic importance. Feedlot, Cow/calf, and Purebred applications . Largest private cattle . women . with . PCOS& . Dr.Nisreen Albezrah. Obs.Gyn. Dept. Head. Ass.Prof. . . Medical College. Taif University. introduction. Polycystic ovary . syndrome(PCOS) . is a heterogeneous endocrine disorder . women . with . PCOS& . Dr.Nisreen Albezrah. Obs.Gyn. Dept. Head. Ass.Prof. . . Medical College. Taif University. introduction. Polycystic ovary . syndrome(PCOS) . is a heterogeneous endocrine disorder . DisclosuresSpeaker BureauRhythm PharmaceuticalsLearning ObjectivesReview the energy balance regulation pathwayTo introduce rare disorders of obesity also known as monogenic obesityReview clinical feat Fat is just what we thought. The cause of excess subcutaneous and visceral fat deposition in an individual is the cumulative effect of an imbalance between the energy of ingested food and that expended in the course of daily activities. . History of cloning. Dolly the sheep – first cloned mammal in 1997***. Very few scientists believe human cloning (reproductive cloning) should be permitted. Most scientists in favor of therapeutic cloning. Alison Holiday. Alzheimer’s Disease (AD). Leptin. Leptin. 116-130. prevents copper induced cell death. Crystal violet assay on leptin and leptin. 116-130. treated cells with . copper. CuCl. 2. -treated. Mark Hatherill. South African Tuberculosis Vaccine Initiative (SATVI). University of Cape Town, South Africa. 2. The case for a therapeutic vaccine for DR-TB. What could a therapeutic vaccine do?. What could we do with a therapeutic vaccine?. David . Litzinger. , PhD. Director, Pharmaceutical Sciences. Amylin Pharmaceuticals, Inc.. PEGS Conference. May 20, 2010. Boston, MA. Small . Molecules. <. 500 Da. Peptides. 1-6 kDa. Proteins. 15-150 kDa. db. /. db. Mice Induced by AZP-3404, a 9-Amino Acid of IGFBP2. Michael D. Culler. 1. , Stéphane Milano. 1. , Michel Ovize. 1. , Thomas Delale. 1. , . Aart. Jan van der Lely. 2. , David Clemmons. 3. 40 Hyperthyroidism or thyrotoxicosis occurs due to excess release of thyroid hormone. These hormones regulate the body’s energy balance and have effects on adipokine level. There are several repo Aging. What is Therapeutic Recreation? . Therapeutic recreation often allows clients to learn to live to the fullest recognizing their abilities. The therapy promotes physicality and assists older adults to explore, discover, or .