Source TG Cogni topic driver Title TDD update TG Cogni Neurocognitive disorders Purpose Discussion Contact Marc Lecoultre Email mlmllabai Abstract This PPT summarized the content of E010 with the TDD for the ID: 931959
Download Presentation The PPT/PDF document "FGAI4H-E-010-A01 Geneva, 30 May – 1 Ju..." is the property of its rightful owner. Permission is granted to download and print the materials on this web site for personal, non-commercial use only, and to display it on your personal computer provided you do not modify the materials and that you retain all copyright notices contained in the materials. By downloading content from our website, you accept the terms of this agreement.
Slide1
FGAI4H-E-010-A01
Geneva, 30 May – 1 June 2019
Source:TG-Cogni topic driverTitle:TDD update: TG-Cogni (Neurocognitive disorders)Purpose:Discussion
Contact:Marc LecoultreE-mail: ml@mllab.ai
Abstract:
This PPT summarized the content of E-010 with the TDD for the
Cogni
, for presentation and discussion during the meeting.
Slide2Meeting E - Topic Group UpdateNeurocognitive disorders (TG-Cogni)
Marc Lecoultreml@mllab.ai
Slide3Overview
This topic group is dedicated to AI against neuro-cognitive diseases. Co-editor Kherif FerahLaboratory for Research in Neuroimaging, Department of Clinical Neurosciences, Faculty of Biology and Medicine, UNIL Centre Hospitalier
Universitaire Vaudois (CHUV) (Switzerland)
Slide4Received proposals
Provide an empirical basis for testing the clinical validity of machine learning-based diagnostics for Alzheimer’s disease (AD) and related dementia syndromes (defined by DSM V as ‘Neurocognitive disorders’) using real world brain imaging and genetic data
Slide5Alzheimer’s disease proposal overview
Current estimates count world-wide over 48 million people suffering from dementia bringing the social cost of care to 1% of world’s gross domestic product – GDP. These numbers led the World Health Organization to classify neurocognitive disorders as a global public health priority
.
Slide6Problem we want to solve
Early-stage detection and classification of dementia using clinical scores, diagnostic, cognitive measures and biological measures (PET, MRI, fMRI, lab results)
Slide7Data availabilityData include both
real world patient’s data and data collected from research cohorts. The data include clinical scores, diagnostic, cognitive measures and biological measures (PET, MRI, fMRI, lab results). The data include patients on more than
6 000 patients on dementia (one of the largest patients’ cohort) different stages of the disease (subjective complains, mild impairments or demented)
Slide8SUBJECTS NUMEROSITY (@ BSL)
TYPE OF DATA COLECTED
Longitudinal Or Cross-Sectional ?
ClinicalDemographicBiologicCognitive abilitiesEpidemiological
Genetic
Imaging
Brain Bank
EEG
Bio Bank
CLINICAL & EPIDEMIOLOGICAL CHARACTERISTICS
69
Longitudinal - clinical, demographic, cognitive abilities, epidemiological, imaging.
Longitudinal
YES
YES
YES
YES
YES
YES
YES
YES
YES
YES
NDD
146
cross- sectional - clinical, demographic, cognitive abilities, epidemiological, imaging.
Cross-sectionalYESYESYESYESYESYESYESYESYESYESPSY147Longitudinal - clinical, demographic, cognitive abilities, epidemiological, biologic, genetic, imaging, bio-bank.LongitudinalYESYESYESYESYESYESYESYESYESYESNDD262cross- sectional - clinical, demographic, cognitive abilities, epidemiological, imaging.Cross-sectionalYESYESYESYESYESYESYESYESYESYESNDD408Longitudinal - clinical, demographic, epidemiological, epidemiological, biologic, genetic, imaging.LongitudinalYESYESYESYESYESYESYESYESYESYESNDD450Longitudinal - clinical, demographic, cognitive abilities, epidemiological, imaging.LongitudinalYESYESYESYESYESYESYESYESYESYESPSY500cross- sectional - clinical, demographic, cognitive abilities, epidemiological, biologic,genetic, imaging.Cross-sectionalYESYESYESYESYESYESYESYESYESYESAgeing565Longitudinal - clinical, demographic, cognitive abilities, epidemiological, imaging.LongitudinalYESYESYESYESYESYESYESYESYESYESNDD600clinical, demographic, imaging.NONEYESYESYESYESYESYESYESYESYESYESHealthy606cross- sectional - clinical, demographic, cognitive abilities, epidemiological,biologic, imaging.Cross-sectionalYESYESYESYESYESYESYESYESYESYESNDD700Cross-sectional – Clincal, cognitive abilities, imaging.Cross-sectionalNONONONONONONONONONOageing750Clinical, demographic, cognitive abilities, epidemiological, biological, , imaging, bio-bank.NONEYESYESYESYESYESYESYESYESYESYESPDD881Longitudinal - clinical, demographic, cognitive abilities, imaging.LongitudinalYESYESYESYESYESYESYESYESYESYESNDD973cross- sectional - clinical, demographic, cognitive abilities, epidemiological, biologic,genetic, imaging (CT), bio-bank.Cross-sectionalYESYESYESYESYESYESYESYESYESYESNDD1000Longitudinal – clinical, demographic, cognitive abilities, epidemiological, genetic, imaging, bio-bank.LongitudinalYESYESYESYESYESYESYESYESYESYEShealth ageing1000Longitudinal – clinical, demographic, cognitive abilities, epidemiological, biological, imaging.LongitudinalYESYESYESYESYESYESYESYESYESYESageing and dementia1000cross- sectional - clinical, demographic, cognitive abilities, epidemiological, imaging.Cross-sectionalYESYESYESYESYESYESYESYESYESYESPSY1113cross- sectional - clinical, demographic, cognitive abilities, epidemiological, imaging.Cross-sectionalYESYESYESYESYESYESYESYESYESYESPSY1169Longitudinal - clinical, demographic, cognitive abilities, epidemiological, biologic, genetic, imaging, bio-bank.LongitudinalYESYESYESYESYESYESYESYESYESYESNDD1225Cross- sectional – Clinical, demographic, cognitive abilities, epidemiological.Cross-sectionalYESYESYESYESYESYESYESYESYESYESNDD1232Longitudinal - clinical, demographic, cognitive abilities, epidemiological, imaging.LongitudinalYESYESYESYESYESYESYESYESYESYESvascular brain damage and dementia1823Longitudinal – clinical, demographic,epidemiological, biological, genetic, cognitive abilities, imaging.LongitudinalYESYESYESYESYESYESYESYESYESYESageing2300Longitudinal - clinical, demographic, cognitive abilities, epidemiological, biologic, imaging.LongitudinalYESYESYESYESYESYESYESYESYESYESPSY2323Longitudinal – clinical, demographic,epidemiological, biological, cognitive abilities, imaging, bio-bank.LongitudinalYESYESYESYESYESYESYESYESYESYESageing and dementia2500cross- sectional - clinical, demographic, cognitive abilities, epidemiological, genetic, imaging.Cross-sectionalYESYESYESYESYESYESYESYESYESYESPSY-NDD2619cross- sectional - clinical, demographic, cognitive abilities, epidemiological, imaging.Cross-sectionalYESYESYESYESYESYESYESYESYESYESNDD2981Longitudinal - clinical, demographic, cognitive abilities, epidemiological, biologic, genetic, imaging.LongitudinalYESYESYESYESYESYESYESYESYESYESPSY2989cross- sectional - clinical, demographic, cognitive abilities, epidemiological,biologic, genetic , imaging.Cross-sectionalYESYESYESYESYESYESYESYESYESYESNDD4000Longitudinal - clinical, demographic, epidemiological, biologic, genetic, imaging, EEG, bio-bank.LongitudinalYESYESYESYESYESYESYESYESYESYESNDD8000Longitudinal - clinical, demographic, cognitive abilities, epidemiological, biologic, genetic, imaging, bio-bank.LongitudinalYESYESYESYESYESYESYESYESYESYEShealth-related condition 9294Longitudinal – clinical, demographic, cognitive abilities, epidemiological, genetic, imaging, bio-bank.LongitudinalYESYESYESYESYESYESYESYESYESYESVascular disease and dementia10994Longitudinal – clinical, demographic,epidemiological, biological, imaging.LongitudinalYESYESYESYESYESYESYESYESYESYEScardiovascular, neurological, ophthalmological, endocrinological, and psychiatric diseases in elderly people 12000Longitudinal - clinical, demographic, cognitive abilities, epidemiological, biologic, genetic, imaging, bio-bank.LongitudinalYESYESYESYESYESYESYESYESYESYESNDD12126Clinical, demographic, cognitive abilities, epidemiological, genetics, bio-bank.NONEYESYESYESYESYESYESYESYESYESYESNDD18000Longitudinal – clinical, demographic, cognitive abilities, epidemiological, biological, imaging, brain-bank.LongitudinalYESYESYESYESYESYESYESYESYESYESageing26000Longitudinal - clinical, demographic, epidemiological, biologic, genetic, imaging, bio-bank.LongitudinalYESYESYESYESYESYESYESYESYESYESPDD30000demographic, cognitive abilities, epidemiological, genetic, imagingNONENONONONONONONONONONOageing200000Longitudinal - clinical, demographic, cognitive abilities, epidemiological, biologic, genetic, imaging.LongitudinalYESYESYESYESYESYESYESYESYESYESAgeing, metabolic, nutrition, lifestyle
Data availability- Update
Slide9Data availability- Update
Other Data providers: large EU cohort,
inTBI
Slide10Data description
Diagnostic- Labels :Total count
Alzheimer's DiseaseMild cognitive impairment (MCI)Cognitively normal (CN)Other Mixed Dementia (MD)
6787
2082
1165
1779
1761
30.67%
17.16%
26.21%
25.94%
Slide11Data description
Slide12Data description
Slide13Data description
Age
Gendereducationleveleducationyears
ab1_40ab1_42
tau
adas
MMSE
MOCA
leftaccumbensarea
leftacgganteriorcingulategyrus
leftainsanteriorinsula
leftamygdala
leftangangulargyrus
leftaorganteriororbitalgyrus
Subset of features
Slide14Data description
Images format requirements:
Must be full brain scans
Must be provided either in DICOM or NIFTI formatThe images must be high-resolution (max. 1.5 mm) T1-weighted sagittal images.
Slide15Data quality
The data have been obtained under each country
ethical and regulation policies, including patient informed consents. The data have been annotated using best clinical practice and described using Common data Element and international classifications (ICD10).The Quality Check evaluates essential image parameters, such as signal-to-noise ratio, inhomogeneity and image resolution. It evaluates images for problems during the processing steps. It allows for comparing quality measures across different scans and sequences.
Slide16Benchmarking
A large representative sample will be created and will be use for the creation of the models. The models will be then validated on the real-world
undisclosed patient’s data.Metric: Analytical metric + Clinical metric (i.e clinical utility)
Slide17TG Progress
Updated status report
for Alzheimer’s disease use caseWrote Call for Topic Group ParticipationHeld online meetings Met potential participants in Europe
Slide18TG Progress : Larger scope and community
Neurocognitive disorder: decreased mental function due to a medical disease other than a psychiatric illness.
Brain injury caused by traumaCardiovascular disordersdegenerative disorders• Alzheimer disease (also called senile dementia, Alzheimer type)• Creutzfeldt-Jakob disease• Diffuse Lewy body disease• Huntington disease• Multiple sclerosis• Normal pressure hydrocephalus• Parkinson disease• Pick disease
Slide19Next steps
Onboard new proposals in
the TGRefine TG description document according to TDD (FGAI4H-C-105)Release public data set for ADPrepare private (undisclosed) data set for AD