Relationship between gastroesophageal reflux disease and recurrent respiratory tract infections - PowerPoint Presentation

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Relationship between gastroesophageal reflux disease and recurrent respiratory tract infections in children

V. V. Lupu, M. Burlea, M. Moscalu, A. Ignat Pediatrics Department, “Gr. T. Popa” University of Medicine and Pharmacy, Iasi, Romania

Introduction

The gastroesophageal reflux disease is the intermittent or permanent passing of the stomach content into the esophagus, which triggers a whole set of digestive, respiratory and/or neurobehavioral symptoms or the absence of any symptoms.

IntroductionRespiratory Manifestations

chronic cough

episodes of obstructive

apnea

wheezing

chronic or recurrent pneumoniasimple chronic

hoarseness

episodes of

cyanosis accompanied by stridor, hiccups, dysphoniaaspiration pneumonia obstructive recurrent bronchitisepisodes of bronchial asthma,recurrent otitis media

Gaude

GS. Pulmonary manifestations of gastroesophageal reflux disease. 

Annals of Thoracic Medicine

. 2009;4(3):115-123.

IntroductionRespiratory Manifestations

Pathological GERD → can be found in 30% to 80% of patients with asthma.

A systematic review of 28 epidemiological studies

→ a 59.2% weighted average prevalence of GERD symptoms in asthmatic patients, compared to 38.1% in controls.

Based on continuous ambulatory esophageal pH-monitoring

→ at least 50% of adults and children have evidence of GERD.The prevalence of GERD-associated cough ranges from 10% to 40%.

In children, the prevalence of GERD as a cause of chronic cough

→ is reported to be 4% to 15%.

Richter JE. Gastroesophageal reflux disease and asthma: The two are directly related. Am J Med. 2000;108:153S–8S.

Purpose

The purpose of our study → to investigate the relationship between GERD and recurrent respiratory tract infections, epidemiology and the effectiveness of treatments for GERD (proton pumps inhibitors).

Material and methods

The study group consists of 53 children who were referred to a pediatric gastroenterology regional center in northeast Romania for evaluation of GERD as a cause of recurrent respiratory tract infections by

24 hours pH monitoring

.

The results of 24 hours esophageal pH monitoring were interpreted using the

Boix Ochoa score. All children with positive score received treatment with proton pump inhibitors and they were reevaluated after 2 months.

Results

GERD proved by a positive Boix Ochoa score was detected in 41 (77.36%) of these children. 12 children (22.64%) had a negative score.

S

tud

y group

RRTI

Control group

N

o

. Ca

ses

%

N

o

. Ca

ses

%

GERD

+

41

77.36%

131

72.38

%-1222.64%5027.62%Total53181

Results

After a 2 months treatment with proton pump inhibitors, reflux remained present in 8 patients (19.51%), and disappeared after another 2 months cure of PPI.

The study of association of recurrent respiratory infections demonstrates the absence of a significant correlation between them and the presence of reflux (χ2 = 1.63, p = 0.20043, 95% CI).

Anyway, improvement was observed in respiratory symptoms after anti-reflux therapy was started.

Chi-

square

2

p

95%

confidence interval

Pearson Chi-

square

-



2

1.639286

0.20043

Co

r

rela

t

i

on coefficient(Spearman Rank R)0.19174940.20205

Discussions

The patient's history → an extremely important part of the diagnosis of GERD-associated asthma. The diagnosis is important to consider

→

significant improvement in symptoms and in asthma control occurs with appropriately treated GERD.

Patients' symptoms suggesting reflux

→ nocturnal cough, worsening of asthma symptoms after eating large meal, drinking alcohol, or being in the supine position.GERD should be considered in asthmatics

→

in those without an intrinsic component and in those not responding to bronchodilator or steroid therapy.

Richter JE. Gastroesophageal reflux disease and asthma: The two are directly related. Am J Med. 2000;108:153S–8S.

Discussions

Patients with chronic cough should have a history taken and physical examination carried out to evaluate common causes of cough (asthma, sinusitis, GERD), as well as chest radiograph. GERD should be considered if there are typical gastrointestinal symptoms

or if

cough remains unexplained after standard investigations

.

The diagnosis of GERD as the cause of cough can only be made with certainty when cough subsides with specific anti-reflux therapy.

Discussions

Esophageal tests that may be helpful in diagnosis → the barium esophagogram, gastroesophageal scintigraphy, and prolonged esophageal pH–monitoring. Esophageal pH- monitoring

→ wa

s considered the gold standard for the diagnosis of GERD and is the only esophageal test that can directly correlate acid reflux episodes with wheezing or other symptoms of bronchospasm.

Sensitivity is improved by using

impedance - pH-monitoring, but this technology has not yet been standardized to a level which would satisfy the definition of a test suitable for routine clinical practice. 

Ahmed T,

Vaezi

MF. The role of pH monitoring in extraesophageal gastro-esophageal reflux disease. Gastrointest Endosc Clin N Am. 2005;15:319–31. 

Discussions

Treatment for GERD → reducing the abnormal backflow, or reflux of acid, into the esophagus; preventing injury to the esophagus or helping it to heal if injury has already occurred.

General measures

Proclive

position at 30-40 degrees

Discussions

Lifestyle modificationssmall and frequent meals, at regular hours;

avoid food and beverages 2 to 3 hours before going to the bed;

avoid sleeping immediately after a meal;

avoidance of food and beverages with a pH of < 5 and/or capability of relaxing the lower esophageal sphincter → alcohol, chocolate, mint, onions, tea, cola, citrus fruits

no active or passive smoking;

be careful

→

there are drugs decreasing LES pressure.

Discussions

PPIsthe most effective acid-suppression medications available are the cornerstone of therapy for GERD and other acid-mediated conditions.

Once-a-day PPIs therapy

→ improves chronic cough in patients with GERD, and the effect of PPI in ameliorating both cough and reflux symptoms continues after treatment ceases.

There is evidence that

2 months with PPIs is sufficient to reduce cough in patients with GERD.

Conclusions

Our results suggest that recurrent respiratory tract infections should be a solid reason for evaluating the presence of a gastroesophageal reflux by 24 hour pH-monitoring. Early diagnosis and anti-reflux therapy in cases with GERD associated with recurrent respiratory complaints can result in significant improvement in symptoms.

Thank you!