PPT-Figure e-1 A: IFN-a is not expressed in CD19+ cells, CD3+ cells, astrocytes or

oligodendrocytes in the active areas of a chronic active MS lesion Staining for IFNa b e h k in green and in a for B cells CD19 in d T cells CD3 and in g astrocytes GFAP and in j . MicroArrays. - Each cell type within an organism expresses a unique combination of genes – this is, in part, what makes cells different from each other. For example, photoreceptor neurons (but not epidermal skin cells) will express . Control of potential T cell self-reactivity: tolerance. Random generation of an . immense T-cell repertoire. . (~. 10. 15. different TCRs. ):. Great opportunity. to recognize every pathogenic antigen. Impact . on t. iming . of . therapy. Nicholas Chiorazzi. The Feinstein Institute for Medical Research. North Shore – LIJ Health System. Manhasset, NY. At all points in time, CLL clones are heterogeneous based on a number of criteria. Stuart S. Winter, MD. Pediatric Hematology/Oncology. The T. John Gribble Endowed Chair. Background- Acute Lymphoblastic Leukemia in Children & Young Adults. Risk Classification Strategy. Through improved approaches to risk classification, therapy intensification, and supportive care, children and young adults with acute lymphoblastic leukemia (ALL) have an overall survival rate that currently exceeds 80%. Brain cells. Neurons and . neuroglia. neuroglia. In CNS. In PNS. Asrocytes. . Schwann cells. Oligodendrocytes. Satellite cells. Microglia . Ependymal. cells. Neuron . Basic units of nervous tissue. .. Surgery Branch, NCI. MEASUREMENT CHALLENGES FOR CAR-T BIOMANUFACTURING. January 29, 2016. Adoptive Cell Therapy for the Treatment of Cancer: The CAR-T Cell Experience. Disclosures. No financial disclosures. By: Chrisanthi Kanaris. Dr. . Lynes. . MCB 5255. 21 March 2012. MDSC= myeloid-derived suppressor cell. Diverse group of cells . Precursors of myeloid cells, dendritic cells, macrophages, granulocytes . Sa . A.Wang. 1. Theodore Laetsch. 2. “Buddy” Frank Fuda. 2 . and. Sindhu Cherian. 3. 1 MD Anderson Cancer Center; 2 University of Texas Southwestern Medical Center; 3 University of Washington Medical Center. Sa . A.Wang. 1. Theodore Laetsch. 2. “Buddy” Frank Fuda. 2 . and. Sindhu Cherian. 3. 1 MD Anderson Cancer Center; 2 University of Texas Southwestern Medical Center; 3 University of Washington Medical Center. some beneficial. some potentially disease causing. immune system . – not an organ system, but a population of cells that inhabit all of our organs and defend the body from agents of disease. especially concentrated in the true organ system – . with . Acceptable Toxicity . but . w. ithout . Chronic B-Cell Aplasia . in . Children . with . Relapsed . or . Refractory Acute Lymphoblastic Leukemia (ALL) Even . After . Allogeneic Hematopoietic Stem Cell Transplantation (HSCT) . The earliest recognizable cell in the B cell lineage in the pro-B cell, in which the first stage of . Ig. H chain gene rearrangement takes place: A D. H. gene segment rearranges to a J. H. gene segment. Pro-B cells express CD19, it is expressed in all stages of B-cell development up to and including the mature B cell" but not plasma cells", pro B cells also express CD10. hCMEC. /D3 cells. The TEM shows one astrocyte in direct contact with the endothelium. . Scale bar = 2. μ. m.. Endothelium. Astrocyte. Collagen gel. Supplementary figure 2. Transmission electron micrograph of . Stem Cell Transplant for . Primary . Immunodeficiencies. Nancy Bunin, MD. Medical Director. , . Cell Therapy and Transplant . Program. Division of Oncology. To DISCUSS. SCID . Newborn Screening. Transplant controversies.