PPT-Microenvironment mapping via Dexter energy transfer on immune cells

by Jacob B Geri James V Oakley Tamara ReyesRobles Tao Wang Stefan J McCarver Cory H White Frances P RodriguezRivera Dann L Parker Erik C Hett Olugbeminiyi O Fadeyi . Zoran . Galic. Ph.D. .. Division of Hematology/Oncology. David Geffen School of Medicine UCLA. zgalic@ucla.edu. August . 11, 2015. In response to pathogens, vertebrate immune systems use two interconnected systems:. Cancer Immunoediting . Elimination➛ Equilibrium➛ Escape. Proinflammatory Reaction . Within the Tumor Microenvironment. Tumor Cell-Mediated Immune Escape. Aberrant Signal 1, 2, or 3 in the Tumor Microenvironment. Super Awesome Powers of Cell Signaling!. Reminder - Do the Questions!. Do the questions, or Mrs. Davis will be so super sad. Plus, this stuff is AWESOME.. Immunologists. 10-11 years of schooling/training. actively. conducting . translational . medicine. research . to further our . understanding. of . cancer biology and to . identify. which . patient populations may . be. more . likely to derive benefit . LYMPHOCYTES. Are the key cells of the immune system. Two types: B and T. Both produced in the bone marrow. B matures in the bone marrow. T matures in the thymus. Immunocompetency. B and T lymphocytes must recognize “self.”. Key attributes of immune system. 4 attributes that characterize the immune system as a whole. specificity. antigen-antibody specificity. diversity. react to millions of antigens. memory. rapid 2° response. The specialists who diagnose and treat immune system disorders are called . immunologists. , and the specialty itself is called . immunology. .. Phagocytes. Phagocytes are often the first immune system cells . 8/1/2017 1 Conflicts and Grants - NIH (R01 EB009040) - NCI SBIR grant with Celldex Therapeutics, Inc. - Project Energy with Johnson & Johnson Chandan Guha, MBBS, PhD Professor and Vice Chair, the tumour microenvironment . in cancer. Last updated: April 2020. Introduction. This chapter provides:. An overview of the regulatory processes involved in . angiogenesis . in normal physiology and cancer. Chapter 21. 2 Defense Systems. Innate Immunity. nonspecific defense that is active immediately upon infection. found in all animals & plants. includes:. outer covering. skin or shell. chemical secretions. A. Anatomical barriers to infections. 1.Mechanical Factors. Skin. : physical barrier and impermeable to most infectious agents. The desquamation of skin epithelium also helps remove bacteria and other infectious agents that have adhered to the epithelial surfaces. . Glioblastoma. Maria Gubbiotti, MD/PhD Candidate. Jefferson Medical College. The burden of brain cancer. <1% chance of developing malignant brain cancer during one’s lifetime. In 2019:. ~23,820 malignant tumors of the brain and spinal cord will be diagnosed. Hypersensitivities. Hypersensitivity. Any immune response against a foreign antigen exaggerated beyond the norm. Four types. Type I (immediate). Type II (cytotoxic). Type III (immune complex–mediated). Four Major Categories of Immune Mechanisms. Humoral. or antibody-mediated immunity . (B lymphocytes). Cell-mediated immunity . (T lymphocytes). Complement system. Phagocytosis. . (. neutrophils. and macrophages) .