PPT-1 1 Immune Regulation, Tolerance, and Autoimmunity

Mark S Anderson MD PhD UCSF Disclosures Research support from Juno Therapeutics Consultant for Sanofi 2 3 Lecture outline Principles of immune regulation Selftolerance mechanisms of central and peripheral . Self-tolerance: concept, significance. Mechanisms of central and peripheral tolerance: deletion, anergy, regulatory T cells . Pathogenesis of autoimmunity: roles of susceptibility genes and environmental factors . Chris Lancaster, Emily Mathews, Jake Turner . Questions:. c.j.lancaster@warwick.ac.uk . Jake.Turner@warwick.ac.uk. E.K.Mathews@warwick.ac.uk. Definitions . Immunological . Tolerance:. Unresponsiveness . Quiz. Emily Matthews (. e.k.matthews@warwick.ac.uk. ). Chris Lancaster (. c.j.lancaster@warwick.ac.uk. ). Jake Turner (. jake.turner@warwick.ac.uk. ) . Question 1. Define autoimmunity ( 4 marks). 1) . Special thanks to Dr. Todd Watts DC . Barbara Stuart, APRN, NP-C, CEN. Integrative Medical Practitioners. Presented by . DoTERRA. Diamond Melody . Covino. Recommended Reading. Hormonal cycle of Thyroid. immune regulation -- 1. Abul K. . Abbas. UCSF. FOCiS. 2. Lecture outline. Principles of immune regulation . Self-tolerance; mechanisms of central and peripheral . tolerance. Inhibitory receptors of T cells . Abul K. Abbas. UCSF. FOCiS. 2. Lecture outline. Self-tolerance; central and peripheral tolerance. Inhibitory receptors of T cells . Regulatory T cells . 3. Immunological tolerance. Definition:. . unresponsiveness to an antigen induced by exposure of lymphocytes to that antigen; antigen-specific (unlike “immunosuppression”). Assistant Professor. Department of Microbiology. AIIMS, Rishikesh. Learning objectives. By the end of this session student should be able to understand:. Central and peripheral tolerance. Theories of autoimmunity. By: . Dr Puneet Kumar Gupta . Assistant Professor, Microbiology. 1. 2. 3. 4. 5. 6. 7. 8. Tolerance and Autoimmunity. 9. What is tolerance?. Mechanisms to protect from potentially self reacting lymphocytes. . immunopathology. concerns disorders caused by alterations of the immune response. 3 main categories of alterations:. . excessive response hypersensitivity reactions. inappropriate . . response . . immunological tolerance. Immunological . tolerance is a state of unresponsiveness to a particular antigen to which a person has been exposed earlier. .. . . The important aspect of tolerance is the self-tolerance, which prevents the body to mount immune response against self-antigens. Immunological unresponsiveness to self is referred to as . tolerance. or . self-tolerance. Very important to human health. How is this achieved?. -cells with receptors for self-antigens are destroyed in the thymus or bone marrow (central tolerance). Autoimmunity March 2016 What is autoimmunity? In healthy individuals the immune system constantly protects us from the native and foreign microorganisms – such as viruses, bacteria, and parasit Autoimmunity. is the system of immune responses of an organism against its own cells and tissues. Any disease that results from such an aberrant immune response is termed an autoimmune disease.. These . 3. rd. International . Conference. and . Exhibition. . on. Clinical. & . Cellular. . Immunology. September. 29 - . October. 01, 2014 Baltimore, USA. Rafael Correa Rocha. Laboratory. of . Immune-regulation.