PPT-1 1 Immune Regulation, Tolerance, and Autoimmunity

Mark S Anderson MD PhD UCSF Disclosures Research support from Juno Therapeutics Consultant for Sanofi 2 3 Lecture outline Principles of immune regulation Selftolerance mechanisms of central and peripheral . Chris Lancaster, Emily Mathews, Jake Turner . Questions:. c.j.lancaster@warwick.ac.uk . Jake.Turner@warwick.ac.uk. E.K.Mathews@warwick.ac.uk. Definitions . Immunological . Tolerance:. Unresponsiveness . Quiz. Emily Matthews (. e.k.matthews@warwick.ac.uk. ). Chris Lancaster (. c.j.lancaster@warwick.ac.uk. ). Jake Turner (. jake.turner@warwick.ac.uk. ) . Question 1. Define autoimmunity ( 4 marks). 1) . Grace Piggott. Junior. University of Wisconsin Stout. Advisor Dr. Fassil Fanta. Introduction. Risk tolerance . is defined as . the degree of variability in investment returns that an individual is willing to withstand. Special thanks to Dr. Todd Watts DC . Barbara Stuart, APRN, NP-C, CEN. Integrative Medical Practitioners. Presented by . DoTERRA. Diamond Melody . Covino. Recommended Reading. Hormonal cycle of Thyroid. immune regulation -- 1. Abul K. . Abbas. UCSF. FOCiS. 2. Lecture outline. Principles of immune regulation . Self-tolerance; mechanisms of central and peripheral . tolerance. Inhibitory receptors of T cells . Michael Dougan, MD, PhD. Director of the Immunotherapy Mucosal Toxicities Program. Massachusetts General Hospital. 21 March 2018. Cancer is like an infection that can’t be cleared. Mutations can be recognized. Immunotherapy. George Weiner, MD. Director, Holden Comprehensive Cancer Center. Professor, Department of Internal Medicine. George Weiner, MD. Disclosure. Consultant and Research Funding. Checkmate Pharmaceuticals. HIV. (Human immunodeficiency virus)- a virus that attacks the immune system.. Infection with HIV can be prevented. Responsible decisions is the most valuable tool for protection against HIV.. Example: Abstinence from sexual activity and injecting drugs reduce your risk.. Anna Postolova, MD MPH. Allergy/Immunology/Rheumatology. Menlo Medical Clinic. Stanford Health Care . Disclosures . Nothing to disclose. Objectives. Recognize aspects of history and presentation that are suggestive of a primary immunodeficiency or immune dysregulatory syndrome in rheumatology patients. By: . Dr Puneet Kumar Gupta . Assistant Professor, Microbiology. 1. 2. 3. 4. 5. 6. 7. 8. Tolerance and Autoimmunity. 9. What is tolerance?. Mechanisms to protect from potentially self reacting lymphocytes. . Immunological unresponsiveness to self is referred to as . tolerance. or . self-tolerance. Very important to human health. How is this achieved?. -cells with receptors for self-antigens are destroyed in the thymus or bone marrow (central tolerance). Autoimmunity March 2016 What is autoimmunity? In healthy individuals the immune system constantly protects us from the native and foreign microorganisms – such as viruses, bacteria, and parasit Marian . Rewers, MD, PhD. Sponsors:. Patten-Davis Foundation. Autoimmunity Screening for Kids (ASK), 2017-2022 . Screened >30,000 Colorado general population children 1-17 y old. Prevalence of pre-symptomatic T1D - 1.0% (95%CI –0.9- 1.1%). 3. rd. International . Conference. and . Exhibition. . on. Clinical. & . Cellular. . Immunology. September. 29 - . October. 01, 2014 Baltimore, USA. Rafael Correa Rocha. Laboratory. of . Immune-regulation.