PPT-Tolerance and Regulation of the Immune Response

Immunological unresponsiveness to self is referred to as tolerance or selftolerance Very important to human health How is this achieved cells with receptors for selfantigens are destroyed in the thymus or bone marrow central tolerance. Chris Lancaster, Emily Mathews, Jake Turner . Questions:. c.j.lancaster@warwick.ac.uk . Jake.Turner@warwick.ac.uk. E.K.Mathews@warwick.ac.uk. Definitions . Immunological . Tolerance:. Unresponsiveness . Founded in 2016. Location. BioHub. at . Alderley. Park (UK). Management Team. Dr.. Ir. Robert-Jan Lamers. Dr.. Masih Alam. A CRO offering specialised lab services . in the . field of immunology:. Super Awesome Powers of Cell Signaling!. Reminder - Do the Questions!. Do the questions, or Mrs. Davis will be so super sad. Plus, this stuff is AWESOME.. Immunologists. 10-11 years of schooling/training. PATH 417A. Jen Yong. Case. : . Food-borne bacterial infection. “One Too Many Hamburgers”. 10-year-old Ronnie McDonald has developed . abdominal cramps. , . bloody diarrhea. and a . low grade fever. Non-specific Immunity. Born with some immunity . Helps prevent disease. Helps slow disease progression. First line of defense. Non-specific, cont. .. Physical Barrier- . unbroken skin . Understand techniques, strategies, & systems used to foster self-understanding & enhance relationships with others. What is Tolerance?. Tolerance – the capacity to accept deviation from the norm. Abul K. Abbas. UCSF. FOCiS. 2. Lecture outline. Self-tolerance; central and peripheral tolerance. Inhibitory receptors of T cells . Regulatory T cells . 3. Immunological tolerance. Definition:. . unresponsiveness to an antigen induced by exposure of lymphocytes to that antigen; antigen-specific (unlike “immunosuppression”). Chapter 4. Introduction. Molecules recognized as “non-self” are antigens. Several mechanisms to protect itself . First level of protection include physical and biochemical-skin, acid in stomach. Second level of protection phagocytic cells, enzymes, and proteins. Maria Bleier . PATH 417. Overview. The Case. 10 . yr. old male patient . Ronnie McDonald.. Developed abdominal cramps, bloody diarrhea and low grade fever. Physician’s examination: . Asks about history in terms of food consumed – undercooked hamburgers from previous weekend as prime suspect. . immunological tolerance. Immunological . tolerance is a state of unresponsiveness to a particular antigen to which a person has been exposed earlier. .. . . The important aspect of tolerance is the self-tolerance, which prevents the body to mount immune response against self-antigens. By: Brittaney Luu. The Innate Immune Response. Symptoms. The Physical Barrier. A . keratin plug . is present in non-lactating women to prevent the entry of bacteria created from the stratified squamous epithelium.. CfE. . Advanced Higher Biology. Unit . 2: . Organisms and Evolution. If you have done Higher Human Biology this is just revision!!! Use the key areas to create revision notes!. HOMEWORK: ACTIVITY G – Self Study Task – Immune response to parasites. 3. rd. International . Conference. and . Exhibition. . on. Clinical. & . Cellular. . Immunology. September. 29 - . October. 01, 2014 Baltimore, USA. Rafael Correa Rocha. Laboratory. of . Immune-regulation. Adaptive . Non-adaptive (. cell injury-----cell death). hypertrophy. Dysplasia. hyperplasia. neoplasia. Atrophy. Degeneration. Metaplasia. Necrosis, apoptosis. & gangrene. Reversible. Reversible* / Irreversible.