PPT-Tolerance and Regulation of the Immune Response

Immunological unresponsiveness to self is referred to as tolerance or selftolerance Very important to human health How is this achieved cells with receptors for selfantigens are destroyed in the thymus or bone marrow central tolerance. Chris Lancaster, Emily Mathews, Jake Turner . Questions:. c.j.lancaster@warwick.ac.uk . Jake.Turner@warwick.ac.uk. E.K.Mathews@warwick.ac.uk. Definitions . Immunological . Tolerance:. Unresponsiveness . Mark S. Anderson, MD, PhD. UCSF. Disclosures. Research support from Juno Therapeutics. Consultant for . Sanofi. 2. 3. Lecture outline. Principles of immune regulation . Self-tolerance; mechanisms of central and peripheral . immune regulation -- 1. Abul K. . Abbas. UCSF. FOCiS. 2. Lecture outline. Principles of immune regulation . Self-tolerance; mechanisms of central and peripheral . tolerance. Inhibitory receptors of T cells . Immunology. - the study of host defense mechanisms. Immunity. -. ability of the host to protect itself against foreign organisms. Resistance to disease.. Antigen (Ag)- . is a foreign substance that can elicit specific immune response (IR) when is immunogenic. LYMPHOCYTES. Are the key cells of the immune system. Two types: B and T. Both produced in the bone marrow. B matures in the bone marrow. T matures in the thymus. Immunocompetency. B and T lymphocytes must recognize “self.”. Abul K. Abbas. UCSF. FOCiS. 2. Lecture outline. Self-tolerance; central and peripheral tolerance. Inhibitory receptors of T cells . Regulatory T cells . 3. Immunological tolerance. Definition:. . unresponsiveness to an antigen induced by exposure of lymphocytes to that antigen; antigen-specific (unlike “immunosuppression”). Maria Bleier . PATH 417. Overview. The Case. 10 . yr. old male patient . Ronnie McDonald.. Developed abdominal cramps, bloody diarrhea and low grade fever. Physician’s examination: . Asks about history in terms of food consumed – undercooked hamburgers from previous weekend as prime suspect. Immune Response. Adaptive Immune. 2. Adaptive or Acquired Immune Response. Protects against infectious agents and abnormal body cells . Amplifies the inflammatory . response. Activates complement. 3. . immunological tolerance. Immunological . tolerance is a state of unresponsiveness to a particular antigen to which a person has been exposed earlier. .. . . The important aspect of tolerance is the self-tolerance, which prevents the body to mount immune response against self-antigens. The Immune System. The immune system is a group of cells & soluble molecules, which interact & distinguish patterns in the body as “self” or “non-self,” in order to eliminate those that are “non-self.”. By: Brittaney Luu. The Innate Immune Response. Symptoms. The Physical Barrier. A . keratin plug . is present in non-lactating women to prevent the entry of bacteria created from the stratified squamous epithelium..    Abbreviations: Ab, antibody; ADA, anti - drug antibodies; Ag, antigen; BiPAP, bilevel positive airway pressure; CDER, Center for Drug Evaluation and Research CNS; central nervous s 3. rd. International . Conference. and . Exhibition. . on. Clinical. & . Cellular. . Immunology. September. 29 - . October. 01, 2014 Baltimore, USA. Rafael Correa Rocha. Laboratory. of . Immune-regulation. Adaptive . Non-adaptive (. cell injury-----cell death). hypertrophy. Dysplasia. hyperplasia. neoplasia. Atrophy. Degeneration. Metaplasia. Necrosis, apoptosis. & gangrene. Reversible. Reversible* / Irreversible.