PPT-Dr . Mayssaa Essam IMMUNOLOGICAL TOLERANCE AND AUTOIMMUNITY

immunological tolerance Immunological tolerance is a state of unresponsiveness to a particular antigen to which a person has been exposed earlier The important aspect of tolerance is the selftolerance which prevents the body to mount immune response against selfantigens. Self-tolerance: concept, significance. Mechanisms of central and peripheral tolerance: deletion, anergy, regulatory T cells . Pathogenesis of autoimmunity: roles of susceptibility genes and environmental factors . Chris Lancaster, Emily Mathews, Jake Turner . Questions:. c.j.lancaster@warwick.ac.uk . Jake.Turner@warwick.ac.uk. E.K.Mathews@warwick.ac.uk. Definitions . Immunological . Tolerance:. Unresponsiveness . Quiz. Emily Matthews (. e.k.matthews@warwick.ac.uk. ). Chris Lancaster (. c.j.lancaster@warwick.ac.uk. ). Jake Turner (. jake.turner@warwick.ac.uk. ) . Question 1. Define autoimmunity ( 4 marks). 1) . Introduction. A. There are three types of immunological disorders. 1. Hypersensitivity. 2. Autoimmune disease. 3. Immunodeficiency. B. Hypersensitivity reactions to usually harmless substances are often called allergies or allergic reactions. Sally S. Dickerson, MA, Margret E. . Kemeny. , PhD, . Najim. Aziz, MD, Kevin H. Kim, PhD, and John L. Fahey, MD. Presented by: Dominic Furco. Introduction . Testing how specific emotions effect immunological response. Introduction. A. There are three types of immunological disorders. 1. Hypersensitivity. 2. Autoimmune disease. 3. Immunodeficiency. B. Hypersensitivity reactions to usually harmless substances are often called allergies or allergic reactions. Mark S. Anderson, MD, PhD. UCSF. Disclosures. Research support from Juno Therapeutics. Consultant for . Sanofi. 2. 3. Lecture outline. Principles of immune regulation . Self-tolerance; mechanisms of central and peripheral . immune regulation -- 1. Abul K. . Abbas. UCSF. FOCiS. 2. Lecture outline. Principles of immune regulation . Self-tolerance; mechanisms of central and peripheral . tolerance. Inhibitory receptors of T cells . ChemDiv. Inc.. 2017. Knowledge Mining Sources. PubChem Database. Thomson Integrity. Scientific publication & . Patents . Protein Data Bank. SciFinder. 2. Knowledge Progression & Selection. Reference Compounds. Assistant Professor. Department of Microbiology. AIIMS, Rishikesh. Learning objectives. By the end of this session student should be able to understand:. Central and peripheral tolerance. Theories of autoimmunity. AUTOIMMUNE DISEASES. AUTOIMMUNITY. The . term autoimmunity refers to a failure of the body’s immune system to recognize its own cells and tissues as “self”, Instead immune responses are launched against these cells and tissues as if they were foreign or invading bodies. Biotechnology?. * . Biotechnology . —the use of biological processes; and . technology. —to solve problems or make useful products. . . *Biotechnology . – using living organisms, or the products of living organisms, for human benefit to make a product or solve a problem.. By: . Dr Puneet Kumar Gupta . Assistant Professor, Microbiology. 1. 2. 3. 4. 5. 6. 7. 8. Tolerance and Autoimmunity. 9. What is tolerance?. Mechanisms to protect from potentially self reacting lymphocytes. . Immunological unresponsiveness to self is referred to as . tolerance. or . self-tolerance. Very important to human health. How is this achieved?. -cells with receptors for self-antigens are destroyed in the thymus or bone marrow (central tolerance).