PPT-CLS 223 Lecture # 5 Immune Response

Adaptive Nonadaptive cell injurycell death hypertrophy Dysplasia hyperplasia neoplasia Atrophy Degeneration Metaplasia Necrosis apoptosis amp gangrene Reversible Reversible Irreversible. General principles of host defense. Mechanisms . of host defense against different classes of microbes . Immune evasion by microbes . Injury caused by normally protective immune responses . Strategies for vaccines . THE IMMUNE SYSTEM. NONSPECIFIC DEFENSES AGAINST INFECTION INCLUDE THE. SKIN. MUCOUS MEMBRANES. PHAGOCYTIC CELLS. ANTIMICROBIAL PROTEINS. THE IMMUNE SYSTEM. NONSPECIFIC DEFENSE MEANS THAT THEY DON’T DISTINGUISH BETWEEN MICROBES. Super Awesome Powers of Cell Signaling!. Reminder - Do the Questions!. Do the questions, or Mrs. Davis will be so super sad. Plus, this stuff is AWESOME.. Immunologists. 10-11 years of schooling/training. PATH 417A. Jen Yong. Case. : . Food-borne bacterial infection. “One Too Many Hamburgers”. 10-year-old Ronnie McDonald has developed . abdominal cramps. , . bloody diarrhea. and a . low grade fever. Non-specific Immunity. Born with some immunity . Helps prevent disease. Helps slow disease progression. First line of defense. Non-specific, cont. .. Physical Barrier- . unbroken skin . Non-specific Immunity. Born with some immunity . Helps prevent disease. Helps slow disease progression. First line of defense. Non-specific, cont. .. Physical Barrier- . unbroken skin . Immunology. - the study of host defense mechanisms. Immunity. -. ability of the host to protect itself against foreign organisms. Resistance to disease.. Antigen (Ag)- . is a foreign substance that can elicit specific immune response (IR) when is immunogenic. Kuby. . Immunology. , . 7e: Chapter 1. A historical perspective of immunology. What is immunity?. Immunity is the state of protection against foreign pathogens or substances (antigens). Latin term . LYMPHOCYTES. Are the key cells of the immune system. Two types: B and T. Both produced in the bone marrow. B matures in the bone marrow. T matures in the thymus. Immunocompetency. B and T lymphocytes must recognize “self.”. Maria Bleier . PATH 417. Overview. The Case. 10 . yr. old male patient . Ronnie McDonald.. Developed abdominal cramps, bloody diarrhea and low grade fever. Physician’s examination: . Asks about history in terms of food consumed – undercooked hamburgers from previous weekend as prime suspect. Immune Response. Adaptive Immune. 2. Adaptive or Acquired Immune Response. Protects against infectious agents and abnormal body cells . Amplifies the inflammatory . response. Activates complement. 3. The Immune System. The immune system is a group of cells & soluble molecules, which interact & distinguish patterns in the body as “self” or “non-self,” in order to eliminate those that are “non-self.”. By: Brittaney Luu. The Innate Immune Response. Symptoms. The Physical Barrier. A . keratin plug . is present in non-lactating women to prevent the entry of bacteria created from the stratified squamous epithelium.. Immunological unresponsiveness to self is referred to as . tolerance. or . self-tolerance. Very important to human health. How is this achieved?. -cells with receptors for self-antigens are destroyed in the thymus or bone marrow (central tolerance).