RN MS CNS Chlamydia trachomatis a really weird bacterium Intermediate between virus and bacteria Obligate intracellular parasite Kills the host cell Susceptible to some antibiotics Chlamydia trachomatis life cycle ID: 716073
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CHLAMYDIA
Alice
Beckholt
RN, MS, CNSSlide2
Chlamydia trachomatis, a really weird bacterium
Intermediate between virus and bacteria
Obligate intracellular parasite
Kills the host cell
Susceptible to some antibioticsSlide3
Chlamydia trachomatis life cycle
Life cycle estimated at 24-72 hours
Elemental body (EB)
Reticulate body (RB)Slide4
Virulence factors
Gram negative?
Most infections are asymptomatic, but infectious
Also causes LGV and trachomaSlide5
transmission
Sexual
Non-sexualSlide6
Symptoms of genital chlamydia
The vast majority of persons with chlamydial infections are blissfully unaware
Usually noneSlide7
Symptoms in men
Non-
gonococcal
urethritis (NGU)Discharge
DysuriaSlide8
Complications - epididymitis
Fever
Unilateral scrotal pain
Swelling
Tenderness
PAIN!!Slide9
Reiter’s syndrome
Arthritis
Conjunctivitis
Urethritis
Also known as reactive arthritis Slide10
Symptoms in women
Usually none
Cervicitis
Urethritis
Vaginal discharge
Pelvic painSlide11
Complications in women
Pelvic Inflammatory Disease
(PID)
Slide12
Chlamydia and HIV
Untreated Chlamydia can increase the risk of HIV transmission Slide13
Chlamydia in pregnancy and neonates
Preterm delivery
Neonatal conjunctivitis
Neonatal pneumoniaSlide14
Lymphogranuloma
venereum
LGV is caused by chlamydial
serovars
L1, L2, and L3
Genital ulcer
Lymphadenopathy
ProctitisSystemicSerovar
-specific tests not widely availableSlide15
Trachoma
Caused by Chlamydia trachomatis
Not sexually transmitted
Hygiene-relatedSlide16
Diagnosis
Cell cultureSlide17
Diagnosis (continued)
Nucleic Acid Amplification Tests (NAATs)
Non-Amplification TestsSlide18
Treating Chlamydia
Recommended regimens for uncomplicated infections
Azithromycin 1 gram orally once
Doxycycline 100 mg twice daily for 7 days
Alternative regimens for uncomplicated infections
Erythromycin
Ofloxacin
LevofloxacinAmoxacillin Slide19
Treatment (continued)
TREAT ALL PARTNERS WITHIN THE LAST 60-90 DAYS, EVEN IF THEY ARE ASYMPTOMATIC ! Slide20
Prevention, Education and Patient Counseling
Nature of the disease
Transmission
Risk reduction
Screening Slide21
Safe Sex
Nature o