PPT-Genotype Imputation

Author : alexa-scheidler | Published Date : 2016-10-26

Dan Evans devanspsgucsfedu California Pacific Medical Center Research Institute Outline Overview Elements of a Hidden Markov Model HMM Methods used by MACH Method

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Genotype Imputation: Transcript

Dan Evans devanspsgucsfedu California Pacific Medical Center Research Institute Outline Overview Elements of a Hidden Markov Model HMM Methods used by MACH Method comparison with IMPUTEv2. 6 December 2012. Introduction. I. mputation describes the process of predicting genotypes that have not been directly typed in a sample of individuals:. m. issing genotypes at typed variants;. genotypes at un-typed variants that are present in an external high-density “reference panel” of phased . longitudinal health . records. Irene Petersen and Cathy Welch. Primary Care & Population Health. Today. Issues with missing data and multiple imputation of longitudinal records. Twofold algorithm . María. . García. , Chandra Erdman, and Ben Klemens. Outline. Background on the Survey of Income and Program Participation (SIPP). Methods for missing data imputation. - . Randomized Hot deck. - SRMI . Presenter: . Ka. -Kit Lam. 1. Outline. Big Picture and Motivation. IMPUTE. IMPUTE2. Experiments. Conclusion and Discussion. Supplementary : . GWAS. Estimate on mutation rate . 2. Big Picture and Motivation. with large proportions of missing data. :how much is too much? . Texas A&M HSC . Jin. is designed by . Dr. Huber. Korean Female Colon Cancer. Risk. Factors. Range. Event . Non-event. HR. 95% CI. Aleksandar. R. . Mihajlovic. Technische. . Uni. versität München. mihajlovic@mytum.de. +49 176 673 41387. +381 63 183 0081. 1. Overview . Explain input data based imputation algorithm categorization scheme. Katherine Lee. Murdoch Children’s Research Institute &. University of Melbourne. Missing data in epidemiology & clinical research. Widespread problem, especially in long-term follow-up studies. Cattram Nguyen, Katherine Lee, John . Carlin. Biometrics by the Harbour, 30 Nov, 2015. Motivating example: Longitudinal Study of Australian Children (LSAC). 5107 infants (0-1 year) recruited in 2004. Matt Spangler. University of Nebraska-Lincoln. Imputation. Imputation creates data that were not actually collected . I. mputation allows us to retain observations that would otherwise be left out of an analysis. Zhiwu Zhang. Washington State University. Lecture 7: Impute. Homework2 posted, due Feb 17, Wednesday, 3:10PM. M. idterm exam: February . 26, Friday, 50 minutes (. 3:35-4:25PM), 25 . questions. . F. inal exam: May . Warren W. . Kretzschmar. DPhil Genomic Medicine and Statistics. Wellcome. Trust Centre for Human . Genetics, Oxford. , UK . Supervisor: Jonathan . Marchini. C. ommonest . psychiatric disorder and the second ranking cause of morbidity world-. Sarah Medland. Boulder 2015. What is imputation? . (. Marchini. & . Howie. 2010). . 3 main reasons for imputation. Meta-analysis. Fine Mapping. Combining data from different . chips. Other less common uses. WHI using reference haplotypes from the 1000 Genomes Project. Presented by Qing Duan. Dr. Yun Li group. UNC at Chapel Hill. 09-13-2012. Outline. Imputation. Study samples: WHI African Americans and Hispanics samples. Boulder 2015. What is imputation? . (. Marchini. & . Howie. 2010). . 3 main reasons for imputation. Meta-analysis. Fine Mapping. Combining data from different . chips. Other less common uses. sporadic missing data imputation .

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